MIR1276 (microRNA 1276) - Rat Genome Database

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Gene: MIR1276 (microRNA 1276) Homo sapiens
Analyze
Symbol: MIR1276
Name: microRNA 1276
RGD ID: 2312994
HGNC Page HGNC:35347
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-1276; mir-1276; MIRN1276
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381585,770,496 - 85,770,578 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1585,770,496 - 85,770,578 (-)EnsemblGRCh38hg38GRCh38
GRCh371586,313,727 - 86,313,809 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1562,713,653 - 62,713,735 (-)NCBICelera
Cytogenetic Map15q25.3NCBI
HuRef1562,376,833 - 62,376,915 (-)NCBIHuRef
CHM1_11586,155,142 - 86,155,224 (-)NCBICHM1_1
T2T-CHM13v2.01583,522,604 - 83,522,686 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16381832   PMID:18285502   PMID:21037258   PMID:32673666   PMID:34414449   PMID:35048477   PMID:38037531  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_022480.3(KLHL25):c.50C>T (p.Ser17Phe) single nucleotide variant Malignant melanoma [RCV000070934] Chr15:85769761 [GRCh38]
Chr15:86312992 [GRCh37]
Chr15:84113996 [NCBI36]
Chr15:15q25.3		 not provided
GRCh38/hg38 15q25.2-26.3(chr15:83711377-101843270)x3 copy number gain See cases [RCV000135858] Chr15:83711377..101843270 [GRCh38]
Chr15:84380129..102383473 [GRCh37]
Chr15:82171133..100200996 [NCBI36]
Chr15:15q25.2-26.3		 pathogenic
GRCh38/hg38 15q25.2-26.3(chr15:82859676-101810992)x3 copy number gain See cases [RCV000136849] Chr15:82859676..101810992 [GRCh38]
Chr15:83528428..102351195 [GRCh37]
Chr15:81325482..100168718 [NCBI36]
Chr15:15q25.2-26.3		 pathogenic
GRCh38/hg38 15q25.3-26.3(chr15:85397539-101888909)x3 copy number gain See cases [RCV000141899] Chr15:85397539..101888909 [GRCh38]
Chr15:85940770..102429112 [GRCh37]
Chr15:83741774..100246635 [NCBI36]
Chr15:15q25.3-26.3		 pathogenic
GRCh38/hg38 15q23-26.3(chr15:72154949-101920998)x3 copy number gain See cases [RCV000143019] Chr15:72154949..101920998 [GRCh38]
Chr15:72447290..102461201 [GRCh37]
Chr15:70234344..100278724 [NCBI36]
Chr15:15q23-26.3		 pathogenic
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3		 pathogenic
GRCh38/hg38 15q24.2-26.3(chr15:75307767-101723215)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|See cases [RCV000052346] Chr15:75307767..101723215 [GRCh38]
Chr15:75600108..102263418 [GRCh37]
Chr15:73387161..100080941 [NCBI36]
Chr15:15q24.2-26.3		 pathogenic
GRCh38/hg38 15q24.3-26.3(chr15:77543797-101843411)x3 copy number gain See cases [RCV000052347] Chr15:77543797..101843411 [GRCh38]
Chr15:77836139..102383614 [GRCh37]
Chr15:75623194..100201137 [NCBI36]
Chr15:15q24.3-26.3		 pathogenic
GRCh38/hg38 15q25.2-26.3(chr15:84169153-101904929)x3 copy number gain See cases [RCV000052352] Chr15:84169153..101904929 [GRCh38]
Chr15:84837905..102445132 [GRCh37]
Chr15:82628909..100262655 [NCBI36]
Chr15:15q25.2-26.3		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
GFOD1hsa-miR-1276Mirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:13645
Count of gene targets:6097
Count of transcripts:11134
Interacting mature miRNAs:hsa-miR-1276
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 1 1 1 1
Low 117 42 123 82 156 83 169 62 129 79 167 180 6 25 44 1
Below cutoff 61 46 44 21 37 18 81 41 70 17 31 35 3 25 37 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000408707
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1585,770,496 - 85,770,578 (-)Ensembl
RefSeq Acc Id: NR_031682
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381585,770,496 - 85,770,578 (-)NCBI
GRCh371586,313,727 - 86,313,809 (-)RGD
Celera1562,713,653 - 62,713,735 (-)RGD
HuRef1562,376,833 - 62,376,915 (-)RGD
CHM1_11586,155,142 - 86,155,224 (-)NCBI
T2T-CHM13v2.01583,522,604 - 83,522,686 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR1276 COSMIC
Ensembl Genes ENSG00000221634 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000408707 ENTREZGENE
GTEx ENSG00000221634 GTEx
HGNC ID HGNC:35347 ENTREZGENE
Human Proteome Map MIR1276 Human Proteome Map
miRBase MI0006416 ENTREZGENE
NCBI Gene 100302121 ENTREZGENE
PharmGKB PA164722423 PharmGKB
RNAcentral URS000042619A RNACentral
  URS0000759940 RNACentral