MIR1470 (microRNA 1470) - Rat Genome Database

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Gene: MIR1470 (microRNA 1470) Homo sapiens
Analyze
Symbol: MIR1470
Name: microRNA 1470
RGD ID: 2312988
HGNC Page HGNC:35379
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-1470; MIRN1470
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,449,548 - 15,449,608 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1915,449,548 - 15,449,608 (+)EnsemblGRCh38hg38GRCh38
GRCh371915,560,359 - 15,560,419 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1915,456,006 - 15,456,066 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1915,128,103 - 15,128,163 (+)NCBIHuRef
CHM1_11915,560,166 - 15,560,226 (+)NCBICHM1_1
T2T-CHM13v2.01915,574,537 - 15,574,597 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16381832   PMID:18402656   PMID:25545366   PMID:31791584  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
NM_022904.1(RASAL3):c.1992G>A (p.Met664Ile) single nucleotide variant Malignant melanoma [RCV000071965] Chr19:15454529 [GRCh38]
Chr19:15565340 [GRCh37]
Chr19:15426340 [NCBI36]
Chr19:19p13.12		 not provided
GRCh38/hg38 19p13.12-13.11(chr19:14154962-16914313)x1 copy number loss See cases [RCV000134176] Chr19:14154962..16914313 [GRCh38]
Chr19:14265774..17025123 [GRCh37]
Chr19:14126774..16886123 [NCBI36]
Chr19:19p13.12-13.11		 pathogenic
GRCh38/hg38 19p13.12-12(chr19:15133594-24193591)x3 copy number gain See cases [RCV000136696] Chr19:15133594..24193591 [GRCh38]
Chr19:15244405..24376393 [GRCh37]
Chr19:15105405..24168233 [NCBI36]
Chr19:19p13.12-12		 pathogenic|likely pathogenic
GRCh38/hg38 19p13.12-q11(chr19:13974677-27839676)x3 copy number gain See cases [RCV000052912] Chr19:13974677..27839676 [GRCh38]
Chr19:14085489..28330584 [GRCh37]
Chr19:13946489..33022424 [NCBI36]
Chr19:19p13.12-q11		 pathogenic
GRCh38/hg38 19p13.12(chr19:15227306-15496644)x3 copy number gain See cases [RCV000054146] Chr19:15227306..15496644 [GRCh38]
Chr19:15338117..15607455 [GRCh37]
Chr19:15199117..15468455 [NCBI36]
Chr19:19p13.12		 uncertain significance
GRCh38/hg38 19p13.12-13.11(chr19:15014099-16261691) copy number loss Chromosome 19p13.13 deletion syndrome [RCV003223562] Chr19:15014099..16261691 [GRCh38]
Chr19:19p13.12-13.11		 pathogenic|uncertain significance
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:22365
Count of gene targets:10662
Count of transcripts:21174
Interacting mature miRNAs:hsa-miR-1470
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 2 1 1 1 1 2
Below cutoff 2 6 1 8 4 3 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000600745
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1915,449,548 - 15,449,608 (+)Ensembl
RefSeq Acc Id: NR_031716
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381915,449,548 - 15,449,608 (+)NCBI
GRCh371915,560,359 - 15,560,419 (+)RGD
Celera1915,456,006 - 15,456,066 (+)RGD
HuRef1915,128,103 - 15,128,163 (+)RGD
CHM1_11915,560,166 - 15,560,226 (+)NCBI
T2T-CHM13v2.01915,574,537 - 15,574,597 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR1470 COSMIC
Ensembl Genes ENSG00000269782 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000600745 ENTREZGENE
GTEx ENSG00000269782 GTEx
HGNC ID HGNC:35379 ENTREZGENE
Human Proteome Map MIR1470 Human Proteome Map
miRBase MI0007075 ENTREZGENE
NCBI Gene 100302127 ENTREZGENE
PharmGKB PA164722500 PharmGKB
RNAcentral URS0000759FF8 RNACentral
  URS000075EBF5 RNACentral