MIR1257 (microRNA 1257) - Rat Genome Database

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Gene: MIR1257 (microRNA 1257) Homo sapiens
Analyze
Symbol: MIR1257
Name: microRNA 1257
RGD ID: 2312957
HGNC Page HGNC:35322
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-1257; MIRN1257
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382061,953,546 - 61,953,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2061,953,546 - 61,953,662 (-)EnsemblGRCh38hg38GRCh38
GRCh372060,528,602 - 60,528,718 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera2057,265,183 - 57,265,299 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2057,306,930 - 57,307,046 (-)NCBIHuRef
CHM1_12060,429,326 - 60,429,442 (-)NCBICHM1_1
T2T-CHM13v2.02063,741,993 - 63,742,109 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:18285502   PMID:22268729   PMID:30232004  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q13.32-13.33(chr20:59041966-64277321)x3 copy number gain See cases [RCV000135805] Chr20:59041966..64277321 [GRCh38]
Chr20:57617021..62908674 [GRCh37]
Chr20:57050416..62379118 [NCBI36]
Chr20:20q13.32-13.33		 pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33		 pathogenic
GRCh38/hg38 20q13.2-13.33(chr20:56198032-64277321)x3 copy number gain See cases [RCV000138035] Chr20:56198032..64277321 [GRCh38]
Chr20:54773088..62908674 [GRCh37]
Chr20:54206495..62379118 [NCBI36]
Chr20:20q13.2-13.33		 pathogenic
GRCh38/hg38 20q13.33(chr20:61588953-62241744)x3 copy number gain See cases [RCV000137839] Chr20:61588953..62241744 [GRCh38]
Chr20:60164009..60816800 [GRCh37]
Chr20:59597404..60250195 [NCBI36]
Chr20:20q13.33		 uncertain significance
GRCh38/hg38 20q13.33(chr20:61326549-64277326)x3 copy number gain See cases [RCV000139100] Chr20:61326549..64277326 [GRCh38]
Chr20:59901605..62908679 [GRCh37]
Chr20:59335000..62379123 [NCBI36]
Chr20:20q13.33		 pathogenic
GRCh38/hg38 20q13.31-13.33(chr20:57229415-64273089)x3 copy number gain See cases [RCV000141347] Chr20:57229415..64273089 [GRCh38]
Chr20:55804471..62904442 [GRCh37]
Chr20:55237878..62374886 [NCBI36]
Chr20:20q13.31-13.33		 pathogenic
GRCh38/hg38 20q13.2-13.33(chr20:53236165-64284202)x3 copy number gain See cases [RCV000143584] Chr20:53236165..64284202 [GRCh38]
Chr20:51852704..62915555 [GRCh37]
Chr20:51286111..62385999 [NCBI36]
Chr20:20q13.2-13.33		 likely pathogenic
GRCh38/hg38 20q13.12-13.33(chr20:44787704-64277321)x3 copy number gain See cases [RCV000053035] Chr20:44787704..64277321 [GRCh38]
Chr20:43416345..62908674 [GRCh37]
Chr20:42849759..62379118 [NCBI36]
Chr20:20q13.12-13.33		 pathogenic
Single allele duplication not specified [RCV002286379] Chr20:61800345..63644611 [GRCh38]
Chr20:20q13.33		 uncertain significance
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:12207
Count of gene targets:5426
Count of transcripts:9776
Interacting mature miRNAs:hsa-miR-1257
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000408490
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2061,953,546 - 61,953,662 (-)Ensembl
RefSeq Acc Id: NR_031658
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382061,953,546 - 61,953,662 (-)NCBI
GRCh372060,528,602 - 60,528,718 (-)RGD
Celera2057,265,183 - 57,265,299 (-)RGD
HuRef2057,306,930 - 57,307,046 (-)ENTREZGENE
CHM1_12060,429,326 - 60,429,442 (-)NCBI
T2T-CHM13v2.02063,741,993 - 63,742,109 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR1257 COSMIC
Ensembl Genes ENSG00000284193 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000408490 ENTREZGENE
GTEx ENSG00000284193 GTEx
HGNC ID HGNC:35322 ENTREZGENE
Human Proteome Map MIR1257 Human Proteome Map
miRBase MI0006391 ENTREZGENE
NCBI Gene 100302168 ENTREZGENE
PharmGKB PA164722398 PharmGKB
RNAcentral URS000075B4B8 RNACentral
  URS000075DA8E RNACentral