MIR1294 (microRNA 1294) - Rat Genome Database

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Gene: MIR1294 (microRNA 1294) Homo sapiens
Analyze
Symbol: MIR1294
Name: microRNA 1294
RGD ID: 2312948
HGNC Page HGNC:35287
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-1294; mir-1294; MIRN1294
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385154,347,106 - 154,347,247 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5154,347,106 - 154,347,247 (+)EnsemblGRCh38hg38GRCh38
GRCh375153,726,666 - 153,726,807 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera5149,802,350 - 149,802,491 (+)NCBICelera
Cytogenetic Map5q33.2NCBI
HuRef5148,867,497 - 148,867,638 (+)NCBIHuRef
CHM1_15153,159,282 - 153,159,423 (+)NCBICHM1_1
T2T-CHM13v2.05154,881,045 - 154,881,186 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:18285502   PMID:21037258   PMID:25925090   PMID:30229824   PMID:30536306   PMID:30575897   PMID:30591218   PMID:30988074   PMID:31038801   PMID:31114997   PMID:31833046  
PMID:31867014   PMID:32280078   PMID:32651991   PMID:32975228   PMID:33009634   PMID:33880589   PMID:34314478   PMID:34419070   PMID:34784561   PMID:35114891   PMID:35168653   PMID:35285410  
PMID:35312113   PMID:35522362   PMID:37096504   PMID:37303740  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q33.1-34(chr5:152443869-166104392)x1 copy number loss See cases [RCV000138282] Chr5:152443869..166104392 [GRCh38]
Chr5:151823430..165531397 [GRCh37]
Chr5:151803623..165463975 [NCBI36]
Chr5:5q33.1-34		 pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3		 pathogenic
GRCh38/hg38 5q33.1-34(chr5:152761187-167248053)x1 copy number loss See cases [RCV000052144] Chr5:152761187..167248053 [GRCh38]
Chr5:152140747..166675058 [GRCh37]
Chr5:152120940..166607636 [NCBI36]
Chr5:5q33.1-34		 pathogenic
GRCh38/hg38 5q33.1-34(chr5:153195314-164014005)x1 copy number loss See cases [RCV000052145] Chr5:153195314..164014005 [GRCh38]
Chr5:152574874..163441011 [GRCh37]
Chr5:152555067..163373589 [NCBI36]
Chr5:5q33.1-34		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:20070
Count of gene targets:8357
Count of transcripts:15444
Interacting mature miRNAs:hsa-miR-1294
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium
Low 11 10 8 2 51 2 18 6 14 11 32 12 4 11
Below cutoff 56 35 25 7 68 8 101 28 74 18 45 46 2 27 50 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000408503
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5154,347,106 - 154,347,247 (+)Ensembl
RefSeq Acc Id: NR_031626
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385154,347,106 - 154,347,247 (+)NCBI
GRCh375153,726,666 - 153,726,807 (+)RGD
Celera5149,802,350 - 149,802,491 (+)RGD
HuRef5148,867,497 - 148,867,638 (+)ENTREZGENE
CHM1_15153,159,282 - 153,159,423 (+)NCBI
T2T-CHM13v2.05154,881,045 - 154,881,186 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR1294 COSMIC
Ensembl Genes ENSG00000221430 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000408503 ENTREZGENE
GTEx ENSG00000221430 GTEx
HGNC ID HGNC:35287 ENTREZGENE
Human Proteome Map MIR1294 Human Proteome Map
miRBase MI0006356 ENTREZGENE
NCBI Gene 100302181 ENTREZGENE
PharmGKB PA164722448 PharmGKB
RNAcentral URS00001C85C7 RNACentral
  URS000075E3DB RNACentral