MIR644A (microRNA 644a) - Rat Genome Database

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Gene: MIR644A (microRNA 644a) Homo sapiens
Analyze
Symbol: MIR644A
Name: microRNA 644a
RGD ID: 2312876
HGNC Page HGNC:32900
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing and negative regulation of amyloid precursor protein biosynthetic process.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-644; hsa-mir-644a; MIR644; MIRN644
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,466,325 - 34,466,418 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,466,325 - 34,466,418 (+)EnsemblGRCh38hg38GRCh38
GRCh372033,054,130 - 33,054,223 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera2029,803,595 - 29,803,688 (+)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2029,835,070 - 29,835,163 (+)NCBIHuRef
CHM1_12032,955,306 - 32,955,399 (+)NCBICHM1_1
T2T-CHM13v2.02036,189,500 - 36,189,593 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:21982160   PMID:23091630   PMID:27407092   PMID:27409664   PMID:27983935   PMID:28374914   PMID:29898735   PMID:30808676   PMID:34673158  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33		 pathogenic
GRCh38/hg38 20q11.21-11.23(chr20:33432363-36821881)x1 copy number loss See cases [RCV000135440] Chr20:33432363..36821881 [GRCh38]
Chr20:32020169..35450284 [GRCh37]
Chr20:31483830..34883698 [NCBI36]
Chr20:20q11.21-11.23		 pathogenic
GRCh38/hg38 20q11.21-11.23(chr20:32062768-35906606)x3 copy number gain See cases [RCV000141833] Chr20:32062768..35906606 [GRCh38]
Chr20:30650571..34494528 [GRCh37]
Chr20:30114232..33957942 [NCBI36]
Chr20:20q11.21-11.23		 pathogenic
GRCh38/hg38 20p12.2-q12(chr20:9811433-39316956)x3 copy number gain See cases [RCV000052999] Chr20:9811433..39316956 [GRCh38]
Chr20:9792081..37945599 [GRCh37]
Chr20:9740081..37379013 [NCBI36]
Chr20:20p12.2-q12		 pathogenic
GRCh38/hg38 20q11.22-13.11(chr20:34249453-43359749)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053002]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053002]|See cases [RCV000053002] Chr20:34249453..43359749 [GRCh38]
Chr20:32837259..41988389 [GRCh37]
Chr20:32300920..41421803 [NCBI36]
Chr20:20q11.22-13.11		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
GAPDHhsa-miR-644aMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23091630

Predicted Targets
Summary Value
Count of predictions:23241
Count of gene targets:11013
Count of transcripts:20756
Interacting mature miRNAs:hsa-miR-644a
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2 4 53 2 3 1
Low 128 100 116 75 221 77 269 59 145 59 148 183 5 35 130 2
Below cutoff 82 77 58 25 43 12 178 49 70 13 35 71 14 38 100

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385262
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2034,466,325 - 34,466,418 (+)Ensembl
RefSeq Acc Id: NR_030374
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382034,466,325 - 34,466,418 (+)NCBI
GRCh372033,054,130 - 33,054,223 (+)RGD
Celera2029,803,595 - 29,803,688 (+)RGD
HuRef2029,835,070 - 29,835,163 (+)ENTREZGENE
CHM1_12032,955,306 - 32,955,399 (+)NCBI
T2T-CHM13v2.02036,189,500 - 36,189,593 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR644A COSMIC
Ensembl Genes ENSG00000207997 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385262 ENTREZGENE
GTEx ENSG00000207997 GTEx
HGNC ID HGNC:32900 ENTREZGENE
Human Proteome Map MIR644A Human Proteome Map
miRBase MI0003659 ENTREZGENE
NCBI Gene 693229 ENTREZGENE
PharmGKB PA164722940 PharmGKB
RNAcentral URS000067B227 RNACentral
  URS000075C3AA RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-11-22 MIR644A  microRNA 644a  MIR644  microRNA 644  Symbol and/or name change 5135510 APPROVED