Wnt4 (Wnt family member 4) - Rat Genome Database

Name: Wnt4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Wnt4 (Wnt family member 4) Heterocephalus glaber

Analyze

Symbol:

Wnt4

Name:

Wnt family member 4

RGD ID:

18936662

Description:

ENCODES a protein that exhibits receptor ligand activity (ortholog); transcription corepressor activity (ortholog); INVOLVED IN adrenal gland development (ortholog); apoptotic signaling pathway (ortholog); branching involved in ureteric bud morphogenesis (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); 46,XX Sex Reversal with Dysgenesis of Kidneys, Adrenals, and Lungs (ortholog); acute kidney failure (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular matrix (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

protein Wnt-4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WNT4 (Wnt family member 4)	NCBI	Ortholog
Mus musculus (house mouse):	Wnt4 (wingless-type MMTV integration site family, member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Wnt4 (Wnt family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Wnt4 (Wnt family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WNT4 (Wnt family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WNT4 (Wnt family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Wnt4 (Wnt family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WNT4 (Wnt family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	WNT4 (Wnt family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	6,921,811 - 6,933,392 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	6,913,027 - 6,934,650 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ISO)

46,XX Sex Reversal with Dysgenesis of Kidneys, Adrenals, and Lungs (ISO)

acute kidney failure (ISO)

congenital disorder of glycosylation Ir (ISO)

Dwarfism (ISO)

endometrial carcinoma (ISO)

Female Urogenital Diseases (ISO)

Fibroadenoma (ISO)

genetic disease (ISO)

hyperprolinemia type 2 (ISO)

kidney disease (ISO)

Mayer-Rokitansky-Kuster-Hauser syndrome (ISO)

Mullerian aplasia and hyperandrogenism (ISO)

ovarian carcinoma (ISO)

Parkinson's disease 6 (ISO)

Prostatic Neoplasms (ISO)

Urogenital Abnormalities (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adrenal gland development (ISO)

apoptotic signaling pathway (ISO)

branching involved in ureteric bud morphogenesis (ISO)

branching morphogenesis of an epithelial tube (ISO)

canonical Wnt signaling pathway (IEA,ISO)

cell differentiation (ISO)

cell fate commitment (IEA,ISO)

cellular response to estradiol stimulus (ISO)

cellular response to hydrostatic pressure (ISO)

cellular response to starvation (ISO)

cellular response to transforming growth factor beta stimulus (ISO)

embryonic epithelial tube formation (ISO)

epithelial to mesenchymal transition (ISO)

female gonad development (ISO)

female sex determination (ISO)

fibroblast growth factor receptor signaling pathway (ISO)

gamete generation (ISO)

hormone metabolic process (ISO)

immature T cell proliferation in thymus (ISO)

kidney development (ISO)

kidney morphogenesis (ISO)

liver development (ISO)

male gonad development (ISO)

mammary gland epithelium development (ISO)

meiotic nuclear division (ISO)

mesenchymal to epithelial transition (ISO)

mesonephric tubule development (ISO)

mesonephros development (ISO)

metanephric nephron development (ISO)

metanephric nephron morphogenesis (ISO)

metanephric tubule formation (ISO)

metanephros development (ISO)

negative regulation of androgen biosynthetic process (ISO)

negative regulation of apoptotic signaling pathway (ISO)

negative regulation of cell differentiation (ISO)

negative regulation of cell migration (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of fibroblast growth factor receptor signaling pathway (ISO)

negative regulation of gene expression (ISO)

negative regulation of male gonad development (ISO)

negative regulation of steroid biosynthetic process (ISO)

negative regulation of testicular blood vessel morphogenesis (ISO)

negative regulation of testosterone biosynthetic process (ISO)

negative regulation of wound healing (ISO)

nephron development (ISO)

neuron differentiation (IEA)

non-canonical Wnt signaling pathway (ISO)

oocyte development (ISO)

paramesonephric duct development (ISO)

pericyte cell differentiation (ISO)

positive regulation of aldosterone biosynthetic process (ISO)

positive regulation of bone mineralization (ISO)

positive regulation of collagen biosynthetic process (ISO)

positive regulation of cortisol biosynthetic process (ISO)

positive regulation of dermatome development (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of focal adhesion assembly (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of meiotic nuclear division (ISO)

positive regulation of osteoblast differentiation (ISO)

positive regulation of stress fiber assembly (ISO)

regulation of cell-cell adhesion (ISO)

renal vesicle formation (ISO)

renal vesicle induction (ISO)

response to benzoic acid (ISO)

response to estradiol (ISO)

response to retinoic acid (ISO)

Sertoli cell differentiation (ISO)

sex differentiation (ISO)

smooth muscle cell differentiation (ISO)

somatotropin secreting cell differentiation (ISO)

T cell differentiation in thymus (ISO)

tertiary branching involved in mammary gland duct morphogenesis (ISO)

thyroid-stimulating hormone-secreting cell differentiation (ISO)

tube morphogenesis (ISO)

Wnt signaling pathway (IEA)

Cellular Component

cell surface (ISO)

cytoplasm (ISO)

extracellular matrix (ISO)

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

cytokine activity (IEA)

frizzled binding (IEA)

protein binding (ISO)

receptor ligand activity (ISO)

signaling receptor binding (IEA)

transcription corepressor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling pathway (ISO)

Wnt signaling, canonical pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Wnt4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	6,921,811 - 6,933,392 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	6,913,027 - 6,934,650 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

WNT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	22,117,313 - 22,143,097 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	22,117,313 - 22,143,969 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	22,443,806 - 22,469,590 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	22,316,385 - 22,342,106 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	22,191,504 - 22,214,916	NCBI
Celera	1	20,766,732 - 20,792,452 (-)	NCBI		Celera
Cytogenetic Map	1	p36.12	NCBI
HuRef	1	20,687,456 - 20,707,677 (-)	NCBI		HuRef
CHM1_1	1	22,556,295 - 22,576,527 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	21,941,071 - 21,966,860 (-)	NCBI		T2T-CHM13v2.0

Wnt4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	137,004,946 - 137,026,812 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	137,004,800 - 137,027,037 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	137,277,635 - 137,299,501 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	137,277,489 - 137,299,726 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	136,833,550 - 136,852,694 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	136,549,711 - 136,568,855 (+)	NCBI		MGSCv36	mm8
Celera	4	135,495,983 - 135,515,320 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	69.8	NCBI

Wnt4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	154,797,245 - 154,818,565 (+)	NCBI		GRCr8
mRatBN7.2	5	149,513,573 - 149,535,415 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	149,514,018 - 149,532,859 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	152,211,413 - 152,230,231 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	153,985,716 - 154,004,530 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	153,967,711 - 153,986,525 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	155,649,238 - 155,668,065 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	155,649,217 - 155,672,579 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	159,405,855 - 159,424,682 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	156,064,371 - 156,083,198 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	156,074,409 - 156,093,237 (+)	NCBI
Celera	5	147,911,190 - 147,930,012 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Wnt4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	2,319,446 - 2,344,989 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	2,319,446 - 2,344,740 (-)	NCBI	ChiLan1.0	ChiLan1.0

WNT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	204,797,117 - 204,824,726 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	203,909,033 - 203,935,541 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	21,310,228 - 21,335,985 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	22,252,344 - 22,264,858 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	22,255,056 - 22,268,801 (-)	Ensembl	panpan1.1		panPan2

WNT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	77,112,045 - 77,129,702 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	77,101,300 - 77,127,111 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	73,605,854 - 73,632,899 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	77,660,017 - 77,687,063 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	77,659,490 - 77,687,070 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	74,480,520 - 74,507,565 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	75,489,331 - 75,516,389 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	76,493,182 - 76,520,234 (+)	NCBI		UU_Cfam_GSD_1.0

Wnt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	41,798,680 - 41,823,413 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	7,623,463 - 7,635,664 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	7,623,462 - 7,635,416 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WNT4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	80,110,238 - 80,138,165 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	74,137,827 - 74,165,540 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WNT4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	110,517,391 - 110,543,802 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	110,517,564 - 110,541,203 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	5,754,333 - 5,781,060 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021263416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01044674	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSHGLT00000016924 ⟹ ENSHGLP00000016753

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624764	6,921,811 - 6,933,392 (-)	Ensembl

RefSeq Acc Id:

XM_021263416 ⟹ XP_021119075

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624764	6,913,027 - 6,934,650 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_021119075	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000016753

RefSeq Acc Id:	XP_021119075 ⟸ XM_021263416
- UniProtKB:	G5BI02 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSHGLP00000016753 ⟸ ENSHGLT00000016924

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000011986	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000016924	ENTREZGENE
Gene3D-CATH	3.30.2460.20	UniProtKB/TrEMBL
InterPro	Wnt	UniProtKB/TrEMBL
	Wnt4	UniProtKB/TrEMBL
	Wnt_C	UniProtKB/TrEMBL
	Wnt_CS	UniProtKB/TrEMBL
NCBI Gene	Wnt4	ENTREZGENE
PANTHER	PROTEIN WNT-4	UniProtKB/TrEMBL
	WNT RELATED	UniProtKB/TrEMBL
Pfam	wnt	UniProtKB/TrEMBL
PRINTS	WNT4PROTEIN	UniProtKB/TrEMBL
	WNTPROTEIN	UniProtKB/TrEMBL
PROSITE	WNT1	UniProtKB/TrEMBL
SMART	WNT1	UniProtKB/TrEMBL
UniProt	G5BI02	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations