Dgcr2 (DiGeorge syndrome critical region gene 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Dgcr2 (DiGeorge syndrome critical region gene 2) Heterocephalus glaber
Analyze
Symbol: Dgcr2
Name: DiGeorge syndrome critical region gene 2
RGD ID: 18935782
Description: INVOLVED IN cognition (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); chromosome 22q11.2 deletion syndrome, distal (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integral membrane protein DGCR2/IDD
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945204,133 - 297,341 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624945204,374 - 295,551 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dgcr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945204,133 - 297,341 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624945204,374 - 295,551 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DGCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,036,286 - 19,122,412 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,036,282 - 19,122,454 (-)EnsemblGRCh38hg38GRCh38
GRCh372219,023,799 - 19,109,925 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,403,795 - 17,489,967 (-)NCBINCBI36Build 36hg18NCBI36
Build 342217,398,354 - 17,484,458NCBI
Celera222,875,821 - 2,961,991 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef222,645,051 - 2,731,450 (-)NCBIHuRef
CHM1_12219,023,413 - 19,109,549 (-)NCBICHM1_1
T2T-CHM13v2.02219,411,609 - 19,497,031 (-)NCBIT2T-CHM13v2.0
Dgcr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,658,219 - 17,709,592 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,657,346 - 17,716,426 (-)EnsemblGRCm39 Ensembl
GRCm381617,840,355 - 17,891,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,839,482 - 17,898,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv371617,840,448 - 17,891,821 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,753,918 - 17,805,232 (-)NCBIMGSCv36mm8
Celera1618,413,424 - 18,464,793 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.05NCBI
Dgcr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,598,247 - 96,648,791 (+)NCBIGRCr8
mRatBN7.21183,093,961 - 83,144,507 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,094,037 - 83,144,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,822,577 - 91,870,954 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,483,711 - 84,532,093 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,537,326 - 83,585,709 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,242,441 - 87,290,806 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,242,522 - 87,292,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,334,004 - 90,368,883 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01190,819,541 - 90,827,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,082,094 - 85,130,476 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,122,690 - 85,171,073 (+)NCBI
Celera1181,869,972 - 81,918,326 (+)NCBICelera
Cytogenetic Map11q23NCBI
Dgcr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,857,222 - 18,938,680 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,857,222 - 18,938,552 (+)NCBIChiLan1.0ChiLan1.0
DGCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22328,656,421 - 28,742,760 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12231,204,009 - 31,290,361 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0221,790,899 - 1,876,983 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12217,468,780 - 17,554,161 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2217,471,360 - 17,554,161 (-)Ensemblpanpan1.1panPan2
DGCR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,051,598 - 30,143,192 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,054,116 - 30,141,533 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,005,593 - 30,103,011 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02631,452,807 - 31,551,179 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12629,500,963 - 29,598,417 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,125,403 - 29,222,785 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,213,547 - 30,311,954 (+)NCBIUU_Cfam_GSD_1.0
Dgcr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118139,633,631 - 139,720,750 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366193,033,275 - 3,121,093 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366193,033,312 - 3,120,473 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,877,872 - 50,935,564 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,881,260 - 50,935,603 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,387,656 - 54,443,785 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DGCR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,628,092 - 6,710,070 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,628,096 - 6,707,507 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666085222,645 - 304,500 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000001978   ⟹   ENSHGLP00000001932
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624945204,133 - 297,341 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000001979   ⟹   ENSHGLP00000001933
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624945204,616 - 293,285 (+)Ensembl
RefSeq Acc Id: XM_004874866   ⟹   XP_004874923
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624945204,375 - 295,551 (+)NCBI
RefSeq Acc Id: XM_004874867   ⟹   XP_004874924
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624945204,375 - 295,551 (+)NCBI
RefSeq Acc Id: XM_004874869   ⟹   XP_004874926
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624945204,375 - 295,551 (+)NCBI
RefSeq Acc Id: XM_004874870   ⟹   XP_004874927
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624945204,375 - 295,551 (+)NCBI
RefSeq Acc Id: XM_013069319   ⟹   XP_012924773
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624945204,374 - 295,551 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_012924773   ⟸   XM_013069319
- Peptide Label: isoform X2
- UniProtKB: G5C048 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004874923   ⟸   XM_004874866
- Peptide Label: isoform X1
- UniProtKB: G5C048 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004874924   ⟸   XM_004874867
- Peptide Label: isoform X3
- UniProtKB: A0A0P6JGY5 (UniProtKB/TrEMBL),   G5C048 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004874926   ⟸   XM_004874869
- Peptide Label: isoform X4
- UniProtKB: G5C048 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004874927   ⟸   XM_004874870
- Peptide Label: isoform X5
- UniProtKB: G5C048 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000001933   ⟸   ENSHGLT00000001979
RefSeq Acc Id: ENSHGLP00000001932   ⟸   ENSHGLT00000001978


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001472 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100004665 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000001978 ENTREZGENE
  ENSHGLT00000001979 ENTREZGENE
  ENSHGLT00000074461 UniProtKB/TrEMBL
  ENSHGLT00100065318 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/TrEMBL
  CTDL_fold UniProtKB/TrEMBL
  DGCR2-like_CTLD UniProtKB/TrEMBL
  IDD UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  VWF_dom UniProtKB/TrEMBL
NCBI Gene Dgcr2 ENTREZGENE
PANTHER INTEGRAL MEMBRANE PROTEIN DGCR2/IDD UniProtKB/TrEMBL
  PTHR15256 UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/TrEMBL
  Lectin_C UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_2 UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
SMART CLECT UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
UniProt A0A0P6JGY5 ENTREZGENE, UniProtKB/TrEMBL
  G5C048 ENTREZGENE, UniProtKB/TrEMBL