Tm7sf2 (transmembrane 7 superfamily member 2) - Rat Genome Database

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Gene: Tm7sf2 (transmembrane 7 superfamily member 2) Heterocephalus glaber
Analyze
Symbol: Tm7sf2
Name: transmembrane 7 superfamily member 2
RGD ID: 18935154
Description: ENCODES a protein that exhibits delta14-sterol reductase activity (inferred); oxidoreductase activity (inferred); oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor (inferred); INVOLVED IN cholesterol biosynthetic process (inferred); sterol biosynthetic process (inferred); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); glycogen storage disease V (ortholog); high grade glioma (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); intracellular membrane-bounded organelle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: delta(14)-sterol reductase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476721,285,395 - 21,292,922 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476721,287,398 - 21,291,619 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tm7sf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476721,285,395 - 21,292,922 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476721,287,398 - 21,291,619 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TM7SF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,111,872 - 65,116,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,111,845 - 65,116,384 (+)EnsemblGRCh38hg38GRCh38
GRCh371164,879,344 - 64,883,702 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,635,917 - 64,640,283 (+)NCBINCBI36Build 36hg18NCBI36
Build 341164,635,949 - 64,640,274NCBI
Celera1162,205,641 - 62,210,007 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,205,962 - 61,210,344 (+)NCBIHuRef
CHM1_11164,763,003 - 64,767,384 (+)NCBICHM1_1
T2T-CHM13v2.01165,105,151 - 65,109,509 (+)NCBIT2T-CHM13v2.0
Tm7sf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,112,851 - 6,117,880 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,112,851 - 6,118,403 (-)EnsemblGRCm39 Ensembl
GRCm38196,062,821 - 6,067,850 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,062,821 - 6,068,373 (-)EnsemblGRCm38mm10GRCm38
MGSCv37196,062,821 - 6,067,850 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36196,062,822 - 6,067,842 (-)NCBIMGSCv36mm8
Celera195,935,273 - 5,940,302 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
Tm7sf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,785,217 - 212,789,572 (-)NCBIGRCr8
mRatBN7.21203,355,930 - 203,360,287 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,355,931 - 203,360,270 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,708,742 - 211,713,072 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,801,297 - 218,805,620 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,492,366 - 211,496,689 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,426,017 - 221,430,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,425,987 - 221,431,713 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01228,361,453 - 228,365,776 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,700,770 - 208,705,093 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,854,222 - 208,858,546 (-)NCBI
Celera1200,889,630 - 200,893,953 (-)NCBICelera
Cytogenetic Map1q43NCBI
Tm7sf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,086,994 - 20,091,707 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,086,994 - 20,091,707 (-)NCBIChiLan1.0ChiLan1.0
TM7SF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2966,344,472 - 66,349,083 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,387,433 - 67,392,044 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01160,473,934 - 60,478,579 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,812,628 - 63,816,994 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,812,769 - 63,816,812 (+)Ensemblpanpan1.1panPan2
TM7SF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,079,367 - 52,083,762 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,079,425 - 52,085,390 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,687,437 - 50,691,824 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,121,444 - 53,125,832 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,121,446 - 53,127,465 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,216,810 - 52,221,198 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,790,784 - 51,795,181 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01852,585,275 - 52,589,662 (-)NCBIUU_Cfam_GSD_1.0
Tm7sf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,811,361 - 7,815,761 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,253,735 - 4,258,071 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,253,725 - 4,258,198 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TM7SF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,075,068 - 7,081,432 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,076,778 - 7,081,502 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,203,154 - 6,213,508 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TM7SF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,112,528 - 9,117,201 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,112,710 - 9,116,898 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038106,493,575 - 106,498,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000016097   ⟹   ENSHGLP00000015931
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476721,285,395 - 21,292,922 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000016098   ⟹   ENSHGLP00000015932
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476721,287,548 - 21,291,453 (-)Ensembl
RefSeq Acc Id: XM_004852424   ⟹   XP_004852481
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476721,287,398 - 21,291,619 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004852481 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000015931
  ENSHGLP00000048708
  ENSHGLP00100029231
GenBank Protein JAO02372 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004852481   ⟸   XM_004852424
- UniProtKB: A0A0P6JE93 (UniProtKB/TrEMBL),   G5B6L8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000015931   ⟸   ENSHGLT00000016097
RefSeq Acc Id: ENSHGLP00000015932   ⟸   ENSHGLT00000016098


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011381 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100014455 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000016097 ENTREZGENE
  ENSHGLT00000082682 UniProtKB/TrEMBL
  ENSHGLT00100089607 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1630 UniProtKB/TrEMBL
InterPro Ergosterol_biosynth_ERG4_ERG24 UniProtKB/TrEMBL
  Sterol_reductase_CS UniProtKB/TrEMBL
KEGG Report hgl:101699579 UniProtKB/TrEMBL
NCBI Gene Tm7sf2 ENTREZGENE
PANTHER DELTA(14)-STEROL REDUCTASE UniProtKB/TrEMBL
  DELTA(14)-STEROL REDUCTASE TM7SF2 UniProtKB/TrEMBL
Pfam ERG4_ERG24 UniProtKB/TrEMBL
PROSITE STEROL_REDUCT_1 UniProtKB/TrEMBL
  STEROL_REDUCT_2 UniProtKB/TrEMBL
UniProt A0A0P6JE93 ENTREZGENE, UniProtKB/TrEMBL
  G5B6L8 ENTREZGENE, UniProtKB/TrEMBL