Ehhadh (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase) - Rat Genome Database

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Gene: Ehhadh (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase) Heterocephalus glaber
Analyze
Symbol: Ehhadh
Name: enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
RGD ID: 18933541
Description: ENCODES a protein that exhibits 3-hydroxyacyl-CoA dehydrogenase activity (ortholog); delta(3)-delta(2)-enoyl-CoA isomerase activity (ortholog); enzyme binding (ortholog); INVOLVED IN fatty acid beta-oxidation (ortholog); PARTICIPATES IN valproic acid pharmacokinetics pathway; ASSOCIATED WITH cholestasis (ortholog); chronic kidney disease (ortholog); Currarino syndrome (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: peroxisomal bifunctional enzyme
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473071,323,484 - 71,357,109 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473071,323,713 - 71,354,805 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
peroxisome  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ehhadh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473071,323,484 - 71,357,109 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473071,323,713 - 71,354,805 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
EHHADH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383185,190,624 - 185,254,049 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3185,190,624 - 185,281,990 (-)EnsemblGRCh38hg38GRCh38
GRCh373184,908,412 - 184,971,837 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363186,391,106 - 186,454,531 (-)NCBINCBI36Build 36hg18NCBI36
Build 343186,391,115 - 186,454,518NCBI
Celera3183,355,409 - 183,418,245 (-)NCBICelera
Cytogenetic Map3q27.2NCBI
HuRef3182,318,813 - 182,381,574 (-)NCBIHuRef
CHM1_13184,871,265 - 184,934,558 (-)NCBICHM1_1
T2T-CHM13v2.03188,006,637 - 188,069,581 (-)NCBIT2T-CHM13v2.0
Ehhadh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391621,580,035 - 21,606,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1621,580,037 - 21,606,557 (-)EnsemblGRCm39 Ensembl
GRCm381621,761,285 - 21,787,834 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1621,761,287 - 21,787,807 (-)EnsemblGRCm38mm10GRCm38
MGSCv371621,761,358 - 21,787,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361621,675,273 - 21,701,779 (-)NCBIMGSCv36mm8
Celera1622,329,681 - 22,356,230 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1612.86NCBI
Ehhadh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,746,409 - 92,779,647 (+)NCBIGRCr8
mRatBN7.21179,241,927 - 79,275,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1179,241,938 - 79,275,188 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1187,978,647 - 88,012,122 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,632,293 - 80,665,765 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01179,692,993 - 79,726,464 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,945,104 - 82,978,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1182,945,104 - 82,978,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01186,024,803 - 86,057,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,474,161 - 81,507,645 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,531,749 - 81,565,234 (+)NCBI
Celera1178,098,443 - 78,131,686 (+)NCBICelera
Cytogenetic Map11q23NCBI
EHHADH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22183,067,115 - 183,158,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13183,071,836 - 183,162,948 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03182,228,520 - 182,319,339 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13190,705,412 - 190,796,075 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3190,704,695 - 190,796,075 (-)Ensemblpanpan1.1panPan2
EHHADH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13418,021,047 - 18,080,993 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3418,022,353 - 18,080,903 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3422,106,718 - 22,155,425 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03417,929,829 - 17,978,525 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3417,929,617 - 17,990,012 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,965,901 - 18,014,608 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,961,931 - 18,010,564 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03418,191,518 - 18,240,177 (-)NCBIUU_Cfam_GSD_1.0
LOC101954746
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602118,462,099 - 118,574,573 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365784,554,113 - 4,666,428 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365784,554,164 - 4,666,427 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EHHADH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13123,104,101 - 123,176,086 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113123,104,085 - 123,162,119 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213132,800,915 - 132,803,789 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EHHADH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1154,164,795 - 4,228,593 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl154,164,838 - 4,228,651 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606312,921,353 - 12,985,087 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013072248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01003148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSHGLT00000023558   ⟹   ENSHGLP00000023341
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473071,323,484 - 71,357,109 (+)Ensembl
RefSeq Acc Id: XM_013072248   ⟹   XP_012927702
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473071,323,713 - 71,354,805 (+)NCBI
Protein Sequences
Protein RefSeqs XP_012927702 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000023341
Reference Protein Sequences
RefSeq Acc Id: XP_012927702   ⟸   XM_013072248
- UniProtKB: A0A0P6JVW9 (UniProtKB/TrEMBL),   G5BTB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000023341   ⟸   ENSHGLT00000023558


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016634 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000023558 ENTREZGENE
Gene3D-CATH 1.10.1040.50 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro 3-OHacyl-CoA_DH_CS UniProtKB/TrEMBL
  3-OHacyl-CoA_DH_NAD-bd UniProtKB/TrEMBL
  3HC_DH_C UniProtKB/TrEMBL
  6-PGluconate_DH-like_C_sf UniProtKB/TrEMBL
  ClpP/crotonase-like_dom_sf UniProtKB/TrEMBL
  Enoyl-CoA_hyd/isom_CS UniProtKB/TrEMBL
  Enoyl-CoA_hydra/iso UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101699730 UniProtKB/TrEMBL
NCBI Gene Ehhadh ENTREZGENE
PANTHER 3-HYDROXYACYL-COA DEHYROGENASE UniProtKB/TrEMBL
  PEROXISOMAL BIFUNCTIONAL ENZYME UniProtKB/TrEMBL
Pfam 3HCDH UniProtKB/TrEMBL
  3HCDH_N UniProtKB/TrEMBL
  ECH_1 UniProtKB/TrEMBL
PROSITE 3HCDH UniProtKB/TrEMBL
  ENOYL_COA_HYDRATASE UniProtKB/TrEMBL
Superfamily-SCOP SSF48179 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
  SSF52096 UniProtKB/TrEMBL
UniProt A0A0P6JVW9 ENTREZGENE, UniProtKB/TrEMBL
  G5BTB0 ENTREZGENE, UniProtKB/TrEMBL