Gadd45b (growth arrest and DNA damage inducible beta) - Rat Genome Database

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Gene: Gadd45b (growth arrest and DNA damage inducible beta) Heterocephalus glaber
Analyze
Symbol: Gadd45b
Name: growth arrest and DNA damage inducible beta
RGD ID: 18931583
Description: INVOLVED IN positive regulation of apoptotic process (ortholog); positive regulation of JNK cascade (ortholog); positive regulation of MAPK cascade (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); COVID-19 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: growth arrest and DNA damage-inducible protein GADD45 beta; Growth arrest and DNA-damage-inducible protein GADD45 beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,663,485 - 5,665,666 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,663,604 - 5,665,666 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Gadd45b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,663,485 - 5,665,666 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,663,604 - 5,665,666 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GADD45B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,476,127 - 2,478,257 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,476,122 - 2,478,259 (+)EnsemblGRCh38hg38GRCh38
GRCh37192,476,125 - 2,478,255 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,427,135 - 2,429,257 (+)NCBINCBI36Build 36hg18NCBI36
Build 34192,427,256 - 2,429,255NCBI
Celera192,413,616 - 2,415,750 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,247,727 - 2,249,861 (+)NCBIHuRef
CHM1_1192,475,705 - 2,477,840 (+)NCBICHM1_1
T2T-CHM13v2.0192,451,914 - 2,454,045 (+)NCBIT2T-CHM13v2.0
Gadd45b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,765,925 - 80,768,038 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,765,907 - 80,768,038 (+)EnsemblGRCm39 Ensembl
GRCm381080,930,091 - 80,932,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,930,073 - 80,932,204 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,392,836 - 80,394,949 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,333,220 - 80,335,333 (+)NCBIMGSCv36mm8
Celera1081,949,491 - 81,951,604 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Gadd45b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,428,689 - 9,430,991 (-)NCBIGRCr8
mRatBN7.278,778,004 - 8,780,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,778,007 - 8,780,046 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,662,083 - 11,664,112 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,537,577 - 13,539,606 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,404,118 - 11,406,147 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,646,283 - 11,648,338 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,646,269 - 11,648,322 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,813,536 - 11,815,569 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,289,073 - 10,291,102 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,289,072 - 10,291,102 (-)NCBI
Celera76,964,215 - 6,966,244 (-)NCBICelera
Cytogenetic Map7q11NCBI
Gadd45b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,864,868 - 4,867,658 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,864,932 - 4,866,728 (+)NCBIChiLan1.0ChiLan1.0
GADD45B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,858,791 - 6,863,365 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,090,497 - 6,092,629 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,489,263 - 1,491,391 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,451,837 - 2,453,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,451,837 - 2,453,992 (+)Ensemblpanpan1.1panPan2
GADD45B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,627,915 - 56,629,960 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,628,485 - 56,629,730 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,423,662 - 56,425,720 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,360,968 - 57,363,023 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,361,502 - 57,363,100 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,413,407 - 56,415,463 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,898,545 - 56,900,597 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,098,808 - 57,100,864 (-)NCBIUU_Cfam_GSD_1.0
Gadd45b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,355,340 - 216,357,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,477,476 - 1,479,457 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,476,580 - 1,479,444 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GADD45B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,107,929 - 76,111,479 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,107,928 - 76,111,458 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,659,395 - 76,662,926 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GADD45B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,248,566 - 2,250,718 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,248,583 - 2,250,889 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660816,407,398 - 6,410,196 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000021361   ⟹   ENSHGLP00000021158
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248285,663,485 - 5,665,666 (+)Ensembl
RefSeq Acc Id: XM_004865781   ⟹   XP_004865838
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248285,663,604 - 5,665,666 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004865838 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB14633 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000021158
GenBank Protein JAO03230 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004865838   ⟸   XM_004865781
- UniProtKB: A0A0N8EUX0 (UniProtKB/TrEMBL),   G5BZC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000021158   ⟸   ENSHGLT00000021361


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015117 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000021361 ENTREZGENE
Gene3D-CATH 3.30.1330.30 UniProtKB/TrEMBL
InterPro GADD45 UniProtKB/TrEMBL
  L30e-like UniProtKB/TrEMBL
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/TrEMBL
KEGG Report hgl:101710909 UniProtKB/TrEMBL
NCBI Gene Gadd45b ENTREZGENE
PANTHER GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA UniProtKB/TrEMBL
  PTHR10411 UniProtKB/TrEMBL
Pfam Ribosomal_L7Ae UniProtKB/TrEMBL
Superfamily-SCOP SSF55315 UniProtKB/TrEMBL
UniProt A0A0N8EUX0 ENTREZGENE, UniProtKB/TrEMBL
  G5BZC2 ENTREZGENE, UniProtKB/TrEMBL