Edem3 (ER degradation enhancing alpha-mannosidase like protein 3) - Rat Genome Database

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Gene: Edem3 (ER degradation enhancing alpha-mannosidase like protein 3) Heterocephalus glaber
Analyze
Symbol: Edem3
Name: ER degradation enhancing alpha-mannosidase like protein 3
RGD ID: 18929917
Description: ENCODES a protein that exhibits calcium ion binding (inferred); hydrolase activity, acting on glycosyl bonds (inferred); mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (inferred); INVOLVED IN ERAD pathway (ortholog); glycoprotein catabolic process (ortholog); mannoprotein catabolic process (ortholog); ASSOCIATED WITH Congenital Disorder of Glycosylation Type IIv (ortholog); Dwarfism (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN endoplasmic reticulum lumen (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ER degradation-enhancing alpha-mannosidase-like 3; ER degradation-enhancing alpha-mannosidase-like protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248148,838,997 - 8,922,936 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248148,839,016 - 8,924,161 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Edem3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248148,838,997 - 8,922,936 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248148,839,016 - 8,924,161 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
EDEM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381184,690,237 - 184,754,858 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1184,690,237 - 184,754,907 (-)EnsemblGRCh38hg38GRCh38
GRCh371184,659,371 - 184,723,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361182,926,260 - 182,990,327 (-)NCBINCBI36Build 36hg18NCBI36
Build 341181,391,294 - 181,455,361NCBI
Celera1157,770,616 - 157,835,009 (-)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1155,895,030 - 155,959,449 (-)NCBIHuRef
CHM1_11186,082,157 - 186,146,571 (-)NCBICHM1_1
T2T-CHM13v2.01184,053,426 - 184,118,046 (-)NCBIT2T-CHM13v2.0
Edem3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,631,099 - 151,698,079 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,631,122 - 151,697,802 (+)EnsemblGRCm39 Ensembl
GRCm381151,755,344 - 151,822,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1151,755,371 - 151,822,051 (+)EnsemblGRCm38mm10GRCm38
MGSCv371153,602,504 - 153,669,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,517,592 - 153,584,546 (+)NCBIMGSCv36mm8
Celera1154,180,540 - 154,247,550 (+)NCBICelera
Cytogenetic Map1G2NCBI
cM Map164.34NCBI
Edem3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81366,403,022 - 66,470,496 (+)NCBIGRCr8
mRatBN7.21363,858,282 - 63,920,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1363,858,716 - 63,920,523 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1366,467,638 - 66,526,178 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01367,745,616 - 67,804,712 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01365,002,139 - 65,060,678 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01369,135,095 - 69,197,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1369,135,128 - 69,199,511 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01374,109,574 - 74,172,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41366,653,931 - 66,712,432 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1363,782,992 - 63,841,218 (+)NCBICelera
Cytogenetic Map13q21NCBI
Edem3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540623,329,400 - 23,401,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540623,329,400 - 23,401,282 (-)NCBIChiLan1.0ChiLan1.0
EDEM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2164,956,321 - 65,029,915 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,642,899 - 64,713,341 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01160,217,526 - 160,281,785 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,372,977 - 164,436,977 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,372,977 - 164,436,977 (-)Ensemblpanpan1.1panPan2
EDEM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1717,918,902 - 17,991,270 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl717,922,334 - 17,991,596 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha717,504,061 - 17,576,419 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0717,655,246 - 17,725,323 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl717,654,411 - 17,725,335 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1717,561,130 - 17,633,489 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0717,669,748 - 17,742,056 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0717,802,533 - 17,872,533 (-)NCBIUU_Cfam_GSD_1.0
Edem3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934487,506,255 - 87,578,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364815,352,956 - 5,424,944 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364815,352,964 - 5,424,944 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDEM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9125,908,864 - 125,983,029 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19125,908,861 - 125,983,073 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29138,358,619 - 138,428,940 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDEM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12544,619,717 - 44,688,794 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2544,619,861 - 44,685,227 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605545,831,717 - 45,900,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000010300   ⟹   ENSHGLP00000010186
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248148,838,997 - 8,922,936 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000010301   ⟹   ENSHGLP00000010187
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248148,839,217 - 8,920,709 (+)Ensembl
RefSeq Acc Id: XM_004862795   ⟹   XP_004862852
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248148,839,019 - 8,924,161 (+)NCBI
RefSeq Acc Id: XM_004862796   ⟹   XP_004862853
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248148,839,217 - 8,920,709 (+)NCBI
RefSeq Acc Id: XM_021242921   ⟹   XP_021098580
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248148,839,016 - 8,924,161 (+)NCBI
RefSeq Acc Id: XM_021242922   ⟹   XP_021098581
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248148,839,217 - 8,920,709 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004862852 (Get FASTA)   NCBI Sequence Viewer  
  XP_004862853 (Get FASTA)   NCBI Sequence Viewer  
  XP_021098580 (Get FASTA)   NCBI Sequence Viewer  
  XP_021098581 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB08460 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000010186
  ENSHGLP00000010187
GenBank Protein JAN99753 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021098580   ⟸   XM_021242921
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JGA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004862852   ⟸   XM_004862795
- Peptide Label: isoform X3
- UniProtKB: A0A0P6JGA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098581   ⟸   XM_021242922
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JGA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004862853   ⟸   XM_004862796
- Peptide Label: isoform X4
- UniProtKB: A0A0P6JGA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000010186   ⟸   ENSHGLT00000010300
RefSeq Acc Id: ENSHGLP00000010187   ⟸   ENSHGLT00000010301


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000007310 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000010300 ENTREZGENE
  ENSHGLT00000010301 ENTREZGENE
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
  3.50.30.30 UniProtKB/TrEMBL
InterPro 6hp_glycosidase-like_sf UniProtKB/TrEMBL
  EDEM1/2/3 UniProtKB/TrEMBL
  EDEM3_PA UniProtKB/TrEMBL
  Glyco_hydro_47 UniProtKB/TrEMBL
  PA_dom_sf UniProtKB/TrEMBL
  PA_domain UniProtKB/TrEMBL
  Seven-hairpin_glycosidases UniProtKB/TrEMBL
NCBI Gene Edem3 ENTREZGENE
PANTHER ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3 UniProtKB/TrEMBL
  PTHR45679 UniProtKB/TrEMBL
Pfam Glyco_hydro_47 UniProtKB/TrEMBL
  PF02225 UniProtKB/TrEMBL
PRINTS GLYHDRLASE47 UniProtKB/TrEMBL
Superfamily-SCOP PA domain UniProtKB/TrEMBL
  SSF48225 UniProtKB/TrEMBL
UniProt A0A0P6JGA4 ENTREZGENE, UniProtKB/TrEMBL