Ppm1e (protein phosphatase, Mg2+/Mn2+ dependent 1E) - Rat Genome Database

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Gene: Ppm1e (protein phosphatase, Mg2+/Mn2+ dependent 1E) Heterocephalus glaber
Analyze
Symbol: Ppm1e
Name: protein phosphatase, Mg2+/Mn2+ dependent 1E
RGD ID: 18924551
Description: ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to xenobiotic stimulus (ortholog); positive regulation of stress fiber assembly (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Joubert syndrome 1 (ortholog); mulibrey nanism (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Protein phosphatase 1E
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624871753,292 - 898,362 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624871753,327 - 902,384 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ppm1e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624871753,292 - 898,362 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624871753,327 - 902,384 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PPM1E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381758,755,854 - 58,985,179 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,755,854 - 58,985,179 (+)EnsemblGRCh38hg38GRCh38
GRCh371756,833,215 - 57,062,540 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361754,188,231 - 54,417,319 (+)NCBINCBI36Build 36hg18NCBI36
Build 341754,188,230 - 54,417,314NCBI
Celera1753,295,075 - 53,524,883 (+)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1752,193,756 - 52,423,036 (+)NCBIHuRef
CHM1_11756,898,743 - 57,127,990 (+)NCBICHM1_1
T2T-CHM13v2.01759,623,935 - 59,853,253 (+)NCBIT2T-CHM13v2.0
Ppm1e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,117,724 - 87,249,884 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,117,732 - 87,249,849 (-)EnsemblGRCm39 Ensembl
GRCm381187,226,906 - 87,358,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,226,906 - 87,359,023 (-)EnsemblGRCm38mm10GRCm38
MGSCv371187,040,408 - 87,172,496 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,043,101 - 87,175,189 (-)NCBIMGSCv36mm8
Celera1196,828,758 - 96,961,052 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.99NCBI
Ppm1e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81072,548,906 - 72,684,702 (-)NCBIGRCr8
mRatBN7.21072,051,643 - 72,187,439 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,055,208 - 72,187,282 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1076,665,709 - 76,797,777 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,170,612 - 76,302,689 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01071,635,130 - 71,767,204 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01074,548,270 - 74,679,858 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1074,548,270 - 74,679,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,421,043 - 75,552,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41075,516,706 - 75,674,452 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11075,531,075 - 75,688,822 (-)NCBI
Celera1070,971,343 - 71,103,804 (-)NCBICelera
Cytogenetic Map10q26NCBI
Ppm1e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554513,986,715 - 4,137,134 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554513,989,575 - 4,137,400 (-)NCBIChiLan1.0ChiLan1.0
PPM1E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21974,922,877 - 75,152,865 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11779,737,401 - 79,964,254 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01752,832,291 - 53,057,157 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11757,682,786 - 57,903,877 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1757,874,629 - 57,903,205 (+)Ensemblpanpan1.1panPan2
PPM1E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1933,350,379 - 33,560,523 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl933,350,614 - 33,560,272 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha932,584,866 - 32,798,194 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0934,156,099 - 34,369,774 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl934,156,276 - 34,369,771 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1932,942,375 - 33,155,670 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0933,231,422 - 33,444,675 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0933,317,898 - 33,531,250 (+)NCBIUU_Cfam_GSD_1.0
Ppm1e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,646,823 - 32,791,722 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364904,287,309 - 4,428,504 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364904,285,770 - 4,428,213 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1235,051,952 - 35,262,703 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11235,051,936 - 35,262,698 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21236,437,167 - 36,478,098 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPM1E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11634,433,918 - 34,647,076 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660775,233,404 - 5,447,972 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000014338   ⟹   ENSHGLP00000014195
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624871753,292 - 898,362 (+)Ensembl
RefSeq Acc Id: XM_004870349   ⟹   XP_004870406
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624871753,327 - 902,384 (+)NCBI
RefSeq Acc Id: XM_004870350   ⟹   XP_004870407
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624871878,244 - 902,384 (+)NCBI
RefSeq Acc Id: XM_021248701   ⟹   XP_021104360
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624871870,153 - 902,384 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004870406 (Get FASTA)   NCBI Sequence Viewer  
  XP_004870407 (Get FASTA)   NCBI Sequence Viewer  
  XP_021104360 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB01899 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014195
Reference Protein Sequences
RefSeq Acc Id: XP_004870406   ⟸   XM_004870349
- Peptide Label: isoform X1
- UniProtKB: G5AXY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104360   ⟸   XM_021248701
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004870407   ⟸   XM_004870350
- Peptide Label: isoform X3
RefSeq Acc Id: ENSHGLP00000014195   ⟸   ENSHGLT00000014338


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010142 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000014338 ENTREZGENE
Gene3D-CATH PPM-type phosphatase domain UniProtKB/TrEMBL
InterPro PP2C UniProtKB/TrEMBL
  PP2C_BS UniProtKB/TrEMBL
  PPM-type-like_dom_sf UniProtKB/TrEMBL
  PPM-type_phosphatase-like_dom UniProtKB/TrEMBL
NCBI Gene Ppm1e ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1E UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 2C UniProtKB/TrEMBL
Pfam PP2C UniProtKB/TrEMBL
PROSITE PPM_1 UniProtKB/TrEMBL
  PPM_2 UniProtKB/TrEMBL
SMART PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP PP2C-like UniProtKB/TrEMBL
UniProt G5AXY8 ENTREZGENE, UniProtKB/TrEMBL