Twsg1 (twisted gastrulation BMP signaling modulator 1) - Rat Genome Database

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Gene: Twsg1 (twisted gastrulation BMP signaling modulator 1) Heterocephalus glaber
Analyze
Symbol: Twsg1
Name: twisted gastrulation BMP signaling modulator 1
RGD ID: 18923507
Description: ENCODES a protein that exhibits heparin binding (inferred); transforming growth factor beta binding (inferred); INVOLVED IN BMP signaling pathway (ortholog); camera-type eye development (ortholog); chondrocyte differentiation (ortholog); ASSOCIATED WITH chromosome 18p deletion syndrome (ortholog); dystonia (ortholog); holoprosencephaly (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: twisted gastrulation homolog 1; twisted gastrulation protein homolog 1; Twisted gastrulation protein-like protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477018,047,810 - 18,081,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477018,047,790 - 18,081,559 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Twsg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477018,047,810 - 18,081,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477018,047,790 - 18,081,559 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TWSG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,334,773 - 9,402,420 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,334,767 - 9,402,420 (+)EnsemblGRCh38hg38GRCh38
GRCh37189,334,771 - 9,402,418 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36189,324,851 - 9,392,418 (+)NCBINCBI36Build 36hg18NCBI36
Build 34189,324,850 - 9,392,417NCBI
Celera189,219,304 - 9,286,615 (+)NCBICelera
Cytogenetic Map18p11.22NCBI
HuRef189,298,467 - 9,364,729 (+)NCBIHuRef
CHM1_1189,334,596 - 9,402,161 (+)NCBICHM1_1
T2T-CHM13v2.0189,497,987 - 9,565,608 (+)NCBIT2T-CHM13v2.0
Twsg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391766,230,060 - 66,258,198 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1766,228,967 - 66,258,221 (-)EnsemblGRCm39 Ensembl
GRCm381765,923,065 - 65,951,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1765,921,972 - 65,951,226 (-)EnsemblGRCm38mm10GRCm38
MGSCv371766,272,405 - 66,300,527 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361765,822,609 - 65,850,673 (-)NCBIMGSCv36mm8
Celera1770,231,747 - 70,259,874 (-)NCBICelera
Cytogenetic Map17E1.1NCBI
cM Map1735.26NCBI
Twsg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89112,979,972 - 113,014,315 (-)NCBIGRCr8
mRatBN7.29105,533,116 - 105,567,460 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9105,533,136 - 105,567,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9113,944,806 - 113,973,639 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09119,054,620 - 119,083,679 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09117,410,654 - 117,439,487 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09113,699,151 - 113,732,601 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9113,699,170 - 113,732,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09113,230,657 - 113,264,099 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49104,694,731 - 104,729,090 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19104,907,180 - 104,938,570 (-)NCBI
Celera9102,911,360 - 102,940,263 (-)NCBICelera
Cytogenetic Map9q37NCBI
Twsg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554022,652,020 - 2,686,117 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554022,652,020 - 2,685,350 (-)NCBIChiLan1.0ChiLan1.0
TWSG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21729,048,226 - 29,115,502 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11814,740,820 - 14,808,080 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0184,883,688 - 4,950,963 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1187,164,091 - 7,229,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl187,164,091 - 7,229,271 (-)Ensemblpanpan1.1panPan2
TWSG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1775,337,347 - 75,397,485 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl775,335,235 - 75,398,325 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha774,725,544 - 74,790,454 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0775,385,087 - 75,451,743 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl775,385,019 - 75,452,636 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0775,106,123 - 75,167,742 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0775,411,428 - 75,477,211 (+)NCBIUU_Cfam_GSD_1.0
Twsg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049442,673,370 - 2,720,055 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366261,901,680 - 1,946,460 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366261,901,686 - 1,946,554 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TWSG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl698,625,505 - 98,678,258 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1698,629,116 - 98,678,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2691,965,863 - 92,015,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TWSG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11868,225,350 - 68,289,458 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1868,225,343 - 68,290,969 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605043,175,298 - 43,240,621 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000005360   ⟹   ENSHGLP00000005291
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462477018,047,810 - 18,081,761 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000005361   ⟹   ENSHGLP00000005292
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462477018,047,810 - 18,081,761 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000005362   ⟹   ENSHGLP00000005293
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462477018,048,615 - 18,081,761 (+)Ensembl
RefSeq Acc Id: XM_004853235   ⟹   XP_004853292
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477018,047,792 - 18,081,559 (+)NCBI
RefSeq Acc Id: XM_004853236   ⟹   XP_004853293
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477018,047,790 - 18,078,676 (+)NCBI
RefSeq Acc Id: XM_021265249   ⟹   XP_021120908
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477018,047,792 - 18,081,559 (+)NCBI
RefSeq Acc Id: XM_021265250   ⟹   XP_021120909
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477018,048,499 - 18,081,559 (+)NCBI
RefSeq Acc Id: XM_021265251   ⟹   XP_021120910
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477018,047,792 - 18,081,559 (+)NCBI
RefSeq Acc Id: XM_021265252   ⟹   XP_021120911
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477018,047,792 - 18,081,559 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004853293   ⟸   XM_004853236
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021120910   ⟸   XM_021265251
- Peptide Label: isoform X1
- UniProtKB: G5C061 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120908   ⟸   XM_021265249
- Peptide Label: isoform X1
- UniProtKB: G5C061 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004853292   ⟸   XM_004853235
- Peptide Label: isoform X1
- UniProtKB: G5C061 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120911   ⟸   XM_021265252
- Peptide Label: isoform X1
- UniProtKB: G5C061 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120909   ⟸   XM_021265250
- Peptide Label: isoform X1
- UniProtKB: G5C061 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000005292   ⟸   ENSHGLT00000005361
RefSeq Acc Id: ENSHGLP00000005293   ⟸   ENSHGLT00000005362
RefSeq Acc Id: ENSHGLP00000005291   ⟸   ENSHGLT00000005360


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003871 Ensembl, ENTREZGENE
  ENSHGLG00100039147 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000005360 ENTREZGENE
  ENSHGLT00000005361 ENTREZGENE
  ENSHGLT00100014766 UniProtKB/TrEMBL
InterPro Tsg UniProtKB/TrEMBL
KEGG Report hgl:101712397 UniProtKB/TrEMBL
NCBI Gene Twsg1 ENTREZGENE
PANTHER PTHR12312 UniProtKB/TrEMBL
  TWISTED GASTRULATION PROTEIN HOMOLOG 1 UniProtKB/TrEMBL
Pfam Tsg UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
UniProt G5C061 ENTREZGENE, UniProtKB/TrEMBL