Traf3ip2 (TRAF3 interacting protein 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Traf3ip2 (TRAF3 interacting protein 2) Heterocephalus glaber
Analyze
Symbol: Traf3ip2
Name: TRAF3 interacting protein 2
RGD ID: 18923043
Description: ENCODES a protein that exhibits signaling receptor binding (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN B cell apoptotic process (ortholog); humoral immune response (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); Candidiasis, Familial, 8 (ortholog); Discoid Lupus Erythematosus (ortholog); FOUND IN cytoplasmic vesicle (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Adapter protein CIKS
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624933506,254 - 554,015 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624933507,879 - 558,357 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell affinity maturation  (IEA)
B cell apoptotic process  (IEA,ISO)
B cell homeostasis  (IEA)
B cell mediated immunity  (IEA)
CD40 signaling pathway  (IEA)
cellular response to cytokine stimulus  (IEA)
cellular response to interleukin-17  (IEA)
cytokine-mediated signaling pathway  (IEA)
eosinophil homeostasis  (IEA)
eosinophil mediated immunity  (IEA)
establishment of T cell polarity  (IEA)
gene expression  (IEA)
heart development  (IEA)
humoral immune response  (IEA,ISO)
immune response  (IEA)
inflammatory response  (IEA)
interleukin-17-mediated signaling pathway  (IEA)
interleukin-17A-mediated signaling pathway  (IEA)
kidney development  (IEA)
leukocyte activation involved in inflammatory response  (IEA)
lymph node development  (IEA)
mRNA stabilization  (IEA)
mucus secretion  (IEA)
neutrophil activation  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of defense response to virus by host  (IEA)
protein import into nucleus  (IEA)
protein K63-linked ubiquitination  (IEA)
protein localization to nucleus  (IEA)
protein localization to P-body  (IEA)
protein polyubiquitination  (IEA)
protein ubiquitination  (IEA)
response to cytokine  (IEA)
response to xenobiotic stimulus  (IEA)
signal transduction involved in regulation of gene expression  (IEA)
skin development  (IEA)
spleen development  (IEA)
T cell activation  (IEA)
T cell differentiation  (IEA)
T-helper 17 type immune response  (IEA)
transitional two stage B cell differentiation  (IEA)
tumor necrosis factor-mediated signaling pathway  (IEA)
type 2 immune response  (IEA)

Cellular Component
cytoplasmic vesicle  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Traf3ip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624933506,254 - 554,015 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624933507,879 - 558,357 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TRAF3IP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386111,555,381 - 111,605,878 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6111,555,381 - 111,606,906 (-)EnsemblGRCh38hg38GRCh38
GRCh376111,876,584 - 111,927,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366111,986,836 - 112,034,014 (-)NCBINCBI36Build 36hg18NCBI36
Build 346111,986,835 - 112,034,014NCBI
Celera6112,626,739 - 112,674,049 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6109,448,986 - 109,500,061 (-)NCBIHuRef
CHM1_16112,139,458 - 112,190,300 (-)NCBICHM1_1
T2T-CHM13v2.06112,738,381 - 112,788,887 (-)NCBIT2T-CHM13v2.0
Traf3ip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391039,488,930 - 39,531,303 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1039,488,930 - 39,531,303 (+)EnsemblGRCm39 Ensembl
GRCm381039,612,934 - 39,655,307 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1039,612,934 - 39,655,307 (+)EnsemblGRCm38mm10GRCm38
MGSCv371039,332,740 - 39,375,113 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361039,302,350 - 39,344,723 (+)NCBIMGSCv36mm8
Celera1040,498,927 - 40,541,335 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1020.86NCBI
Traf3ip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,565,992 - 44,609,240 (+)NCBIGRCr8
mRatBN7.22043,011,405 - 43,054,654 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,011,450 - 43,054,667 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2044,760,488 - 44,803,525 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02044,419,713 - 44,462,750 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02045,161,986 - 45,205,098 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02044,679,861 - 44,722,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,680,449 - 44,722,872 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02046,401,898 - 46,445,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42043,747,622 - 43,792,255 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2043,727,541 - 43,769,944 (+)NCBICelera
Cytogenetic Map20q12NCBI
Traf3ip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541136,326,926 - 36,363,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541136,328,152 - 36,363,614 (-)NCBIChiLan1.0ChiLan1.0
TRAF3IP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25131,572,937 - 131,620,512 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16129,458,898 - 129,506,170 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06109,367,333 - 109,414,601 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16113,443,540 - 113,490,402 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6113,444,005 - 113,485,533 (-)Ensemblpanpan1.1panPan2
TRAF3IP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11268,029,861 - 68,070,901 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1268,030,197 - 68,058,518 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1267,849,673 - 67,891,354 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01268,911,754 - 68,953,406 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1268,911,760 - 68,952,954 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11268,263,251 - 68,304,918 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01268,109,790 - 68,151,470 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01268,435,643 - 68,477,316 (-)NCBIUU_Cfam_GSD_1.0
Traf3ip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946103,076,436 - 103,116,386 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936679316,277 - 336,557 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936679308,508 - 348,561 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAF3IP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl177,487,577 - 77,541,198 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1177,483,997 - 77,541,557 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,044,462 - 87,102,274 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRAF3IP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11362,272,893 - 62,320,096 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1362,285,589 - 62,324,312 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604034,579,431 - 34,626,946 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000002090   ⟹   ENSHGLP00000002042
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624933506,254 - 554,015 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000002091   ⟹   ENSHGLP00000002043
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624933525,304 - 551,066 (+)Ensembl
RefSeq Acc Id: XM_004874619   ⟹   XP_004874676
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624933544,332 - 551,492 (+)NCBI
RefSeq Acc Id: XM_021252025   ⟹   XP_021107684
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624933507,879 - 551,492 (+)NCBI
RefSeq Acc Id: XM_021252026   ⟹   XP_021107685
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624933507,879 - 558,357 (+)NCBI
RefSeq Acc Id: XM_021252027   ⟹   XP_021107686
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624933507,883 - 551,492 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004874676 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107684 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107685 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107686 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB00750 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000002042
  ENSHGLP00100001666
GenBank Protein JAN99818 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021107685   ⟸   XM_021252026
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021107684   ⟸   XM_021252025
- Peptide Label: isoform X1
- UniProtKB: G5AUN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021107686   ⟸   XM_021252027
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004874676   ⟸   XM_004874619
- Peptide Label: isoform X4
RefSeq Acc Id: ENSHGLP00000002042   ⟸   ENSHGLT00000002090
RefSeq Acc Id: ENSHGLP00000002043   ⟸   ENSHGLT00000002091


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001553 Ensembl, ENTREZGENE
  ENSHGLG00100001305 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000002090 ENTREZGENE
  ENSHGLT00100001705 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.11530 UniProtKB/TrEMBL
InterPro SEFIR_dom UniProtKB/TrEMBL
KEGG Report hgl:101721876 UniProtKB/TrEMBL
NCBI Gene Traf3ip2 ENTREZGENE
PANTHER ADAPTER PROTEIN CIKS UniProtKB/TrEMBL
  E3 UBIQUITIN LIGASE TRAF3IP2 UniProtKB/TrEMBL
Pfam SEFIR UniProtKB/TrEMBL
PROSITE SEFIR UniProtKB/TrEMBL
UniProt G5AUN9 ENTREZGENE, UniProtKB/TrEMBL