Polh (DNA polymerase eta) - Rat Genome Database

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Gene: Polh (DNA polymerase eta) Heterocephalus glaber
Analyze
Symbol: Polh
Name: DNA polymerase eta
RGD ID: 18922014
Description: ENCODES a protein that exhibits damaged DNA binding (inferred); DNA-directed DNA polymerase activity (inferred); metal ion binding (inferred); INVOLVED IN cellular response to UV-C (ortholog); postreplication repair (ortholog); pyrimidine dimer repair (ortholog); ASSOCIATED WITH breast cancer (ortholog); female breast cancer (ortholog); genetic disease (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: polymerase (DNA directed), eta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475416,062,744 - 16,080,042 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475416,061,874 - 16,083,247 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Polh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475416,062,744 - 16,080,042 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475416,061,874 - 16,083,247 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
POLH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38643,576,185 - 43,620,523 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl643,576,185 - 43,620,523 (+)EnsemblGRCh38hg38GRCh38
GRCh37643,543,922 - 43,588,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,651,923 - 43,691,357 (+)NCBINCBI36Build 36hg18NCBI36
Build 34643,651,922 - 43,691,357NCBI
Celera645,095,499 - 45,139,881 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef643,263,100 - 43,307,435 (+)NCBIHuRef
CHM1_1643,546,961 - 43,591,323 (+)NCBICHM1_1
T2T-CHM13v2.0643,404,918 - 43,449,256 (+)NCBIT2T-CHM13v2.0
Polh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,482,281 - 46,513,567 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1746,482,281 - 46,513,571 (-)EnsemblGRCm39 Ensembl
GRCm381746,171,355 - 46,202,641 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,171,355 - 46,202,645 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,308,942 - 46,339,574 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361745,635,574 - 45,666,206 (-)NCBIMGSCv36mm8
Celera1749,603,456 - 49,633,922 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
Polh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,275,929 - 22,310,576 (+)NCBIGRCr8
mRatBN7.2914,778,355 - 14,813,210 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,777,888 - 14,812,723 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx923,362,765 - 23,396,678 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0928,425,448 - 28,459,256 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,726,187 - 26,760,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,163,354 - 17,198,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,163,354 - 17,197,132 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,059,843 - 16,094,495 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4910,341,975 - 10,375,983 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1910,342,536 - 10,372,506 (+)NCBI
Celera912,525,667 - 12,559,453 (+)NCBICelera
Cytogenetic Map9q12NCBI
Polh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,397,141 - 9,414,042 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,392,484 - 9,409,186 (+)NCBIChiLan1.0ChiLan1.0
POLH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2558,076,233 - 58,118,698 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1653,946,017 - 53,987,099 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0643,168,195 - 43,205,811 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1644,462,225 - 44,495,078 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,462,225 - 44,495,704 (+)Ensemblpanpan1.1panPan2
POLH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,034,544 - 12,070,305 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1212,034,583 - 12,069,707 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1212,060,988 - 12,098,002 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01212,518,145 - 12,555,505 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1212,518,182 - 12,553,980 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11212,043,615 - 12,080,592 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,130,512 - 12,167,624 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,224,132 - 12,261,137 (+)NCBIUU_Cfam_GSD_1.0
Polh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,525,646 - 47,560,795 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,401,517 - 16,429,287 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647616,400,026 - 16,434,538 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,567,788 - 38,601,790 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,569,211 - 38,601,794 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2744,152,173 - 44,184,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POLH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,548,454 - 28,585,232 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1728,549,623 - 28,585,206 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604443,630,644 - 43,669,142 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000027573   ⟹   ENSHGLP00000027331
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475416,062,744 - 16,080,042 (-)Ensembl
RefSeq Acc Id: XM_004846485   ⟹   XP_004846542
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475416,061,874 - 16,082,118 (-)NCBI
RefSeq Acc Id: XM_004846486   ⟹   XP_004846543
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475416,061,874 - 16,083,247 (-)NCBI
RefSeq Acc Id: XM_004846487   ⟹   XP_004846544
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475416,061,874 - 16,081,440 (-)NCBI
RefSeq Acc Id: XM_021259758   ⟹   XP_021115417
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475416,061,874 - 16,083,247 (-)NCBI
RefSeq Acc Id: XM_021259760   ⟹   XP_021115419
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475416,061,874 - 16,083,247 (-)NCBI
RefSeq Acc Id: XM_021259761   ⟹   XP_021115420
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475416,061,874 - 16,083,203 (-)NCBI
RefSeq Acc Id: XM_021259762   ⟹   XP_021115421
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475416,061,874 - 16,083,200 (-)NCBI
RefSeq Acc Id: XR_002395652
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475416,064,226 - 16,081,440 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021115419   ⟸   XM_021259760
- Peptide Label: isoform X1
- UniProtKB: G5BNN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004846543   ⟸   XM_004846486
- Peptide Label: isoform X1
- UniProtKB: G5BNN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021115417   ⟸   XM_021259758
- Peptide Label: isoform X1
- UniProtKB: G5BNN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021115420   ⟸   XM_021259761
- Peptide Label: isoform X1
- UniProtKB: G5BNN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021115421   ⟸   XM_021259762
- Peptide Label: isoform X1
- UniProtKB: G5BNN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004846542   ⟸   XM_004846485
- Peptide Label: isoform X1
- UniProtKB: G5BNN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004846544   ⟸   XM_004846487
- Peptide Label: isoform X2
- UniProtKB: G5BNN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000027331   ⟸   ENSHGLT00000027573


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019433 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000027573 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.1490.100 UniProtKB/TrEMBL
  3.30.70.270 UniProtKB/TrEMBL
  3.40.1170.60 UniProtKB/TrEMBL
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/TrEMBL
InterPro DNA/RNA_pol_sf UniProtKB/TrEMBL
  DNA_pol_Y-fam_lit_finger_sf UniProtKB/TrEMBL
  DNA_pol_Y-fam_little_finger UniProtKB/TrEMBL
  Rev_trsase/Diguanyl_cyclase UniProtKB/TrEMBL
  UBZ3 UniProtKB/TrEMBL
  UmuC UniProtKB/TrEMBL
NCBI Gene Polh ENTREZGENE
PANTHER DNA POLYMERASE ETA UniProtKB/TrEMBL
  DNA POLYMERASE ETA UniProtKB/TrEMBL
Pfam IMS UniProtKB/TrEMBL
  IMS_C UniProtKB/TrEMBL
  POLH-Rev1_HhH UniProtKB/TrEMBL
  zf_UBZ UniProtKB/TrEMBL
PIRSF DPol_eta UniProtKB/TrEMBL
PROSITE UMUC UniProtKB/TrEMBL
  ZF_UBZ3 UniProtKB/TrEMBL
Superfamily-SCOP SSF100879 UniProtKB/TrEMBL
  SSF56672 UniProtKB/TrEMBL
UniProt A0A0P6J039_HETGA UniProtKB/TrEMBL
  G5BNN0 ENTREZGENE, UniProtKB/TrEMBL