Dis3l (DIS3 like exosome 3'-5' exoribonuclease) - Rat Genome Database

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Gene: Dis3l (DIS3 like exosome 3'-5' exoribonuclease) Heterocephalus glaber
Analyze
Symbol: Dis3l
Name: DIS3 like exosome 3'-5' exoribonuclease
RGD ID: 18918013
Description: ENCODES a protein that exhibits enzyme binding (ortholog); exoribonuclease II activity (ortholog); INVOLVED IN RNA catabolic process (ortholog); RNA processing (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); neuronal ceroid lipofuscinosis (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DIS3 mitotic control homolog (S. cerevisiae)-like; DIS3-like exonuclease 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247816,326,815 - 6,357,563 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247816,326,815 - 6,357,778 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dis3l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247816,326,815 - 6,357,563 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247816,326,815 - 6,357,778 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DIS3L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381566,293,309 - 66,333,898 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1566,293,217 - 66,333,898 (+)EnsemblGRCh38hg38GRCh38
GRCh371566,585,647 - 66,626,236 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361564,372,714 - 64,413,290 (+)NCBINCBI36Build 36hg18NCBI36
Celera1543,475,728 - 43,516,367 (+)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1543,422,442 - 43,463,097 (+)NCBIHuRef
CHM1_11566,703,802 - 66,744,388 (+)NCBICHM1_1
T2T-CHM13v2.01564,114,976 - 64,155,634 (+)NCBIT2T-CHM13v2.0
Dis3l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39964,214,038 - 64,248,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl964,214,038 - 64,248,570 (-)EnsemblGRCm39 Ensembl
GRCm38964,306,756 - 64,341,403 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl964,306,756 - 64,341,288 (-)EnsemblGRCm38mm10GRCm38
MGSCv37964,154,563 - 64,189,064 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36964,105,015 - 64,139,196 (-)NCBIMGSCv36mm8
Celera961,538,690 - 61,573,278 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.62NCBI
Dis3l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,699,185 - 73,735,581 (-)NCBIGRCr8
mRatBN7.2864,803,925 - 64,840,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,803,927 - 64,840,165 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx870,318,289 - 70,354,630 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0868,590,890 - 68,627,221 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0866,460,869 - 66,497,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0869,771,211 - 69,807,880 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl869,771,197 - 69,807,826 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0869,480,086 - 69,516,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,505,022 - 68,543,039 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1868,524,077 - 68,562,093 (-)NCBI
Celera864,210,371 - 64,246,781 (-)NCBICelera
Cytogenetic Map8q24NCBI
Dis3l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554509,279,323 - 9,314,507 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554509,279,323 - 9,313,402 (-)NCBIChiLan1.0ChiLan1.0
DIS3L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21655,551,172 - 55,592,718 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11559,724,812 - 59,765,464 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01545,246,867 - 45,287,521 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11563,523,512 - 63,563,813 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1563,523,512 - 63,563,813 (+)Ensemblpanpan1.1panPan2
DIS3L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13030,611,690 - 30,639,815 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3030,611,381 - 30,639,812 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3030,538,303 - 30,572,113 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03030,801,013 - 30,834,821 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3030,801,014 - 30,834,818 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13030,730,599 - 30,764,419 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03030,793,879 - 30,827,679 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03031,035,632 - 31,069,740 (+)NCBIUU_Cfam_GSD_1.0
Dis3l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640108,628,954 - 108,666,592 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647126,477,166 - 26,515,995 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647126,477,014 - 26,515,380 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIS3L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,310,448 - 164,353,537 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11164,310,120 - 164,352,182 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,067,202 - 182,108,653 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DIS3L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12617,217,316 - 17,258,356 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2617,216,558 - 17,257,942 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048124,189,610 - 124,231,961 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000010950   ⟹   ENSHGLP00000010828
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247816,326,815 - 6,357,563 (-)Ensembl
RefSeq Acc Id: XM_004855607   ⟹   XP_004855664
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247816,326,815 - 6,357,777 (-)NCBI
RefSeq Acc Id: XM_021237033   ⟹   XP_021092692
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247816,326,815 - 6,357,408 (-)NCBI
RefSeq Acc Id: XM_021237034   ⟹   XP_021092693
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247816,326,815 - 6,357,778 (-)NCBI
RefSeq Acc Id: XM_021237035   ⟹   XP_021092694
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247816,326,815 - 6,357,408 (-)NCBI
RefSeq Acc Id: XM_021237036   ⟹   XP_021092695
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247816,326,815 - 6,357,408 (-)NCBI
RefSeq Acc Id: XM_021237037   ⟹   XP_021092696
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247816,326,815 - 6,347,823 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021092693   ⟸   XM_021237034
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004855664   ⟸   XM_004855607
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021092695   ⟸   XM_021237036
- Peptide Label: isoform X4
- UniProtKB: G5AN84 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092694   ⟸   XM_021237035
- Peptide Label: isoform X4
- UniProtKB: G5AN84 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092692   ⟸   XM_021237033
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021092696   ⟸   XM_021237037
- Peptide Label: isoform X5
RefSeq Acc Id: ENSHGLP00000010828   ⟸   ENSHGLT00000010950


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000007770 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000010950 ENTREZGENE
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
  2.40.50.690 UniProtKB/TrEMBL
  2.40.50.700 UniProtKB/TrEMBL
  5'-nuclease UniProtKB/TrEMBL
InterPro Dis3_CSD2 UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  RNase_II/R UniProtKB/TrEMBL
  RNase_II/R_CS UniProtKB/TrEMBL
  Rrp44_CSD1 UniProtKB/TrEMBL
  RRP44_S1 UniProtKB/TrEMBL
NCBI Gene Dis3l ENTREZGENE
PANTHER PTHR23355:SF30 UniProtKB/TrEMBL
  RIBONUCLEASE UniProtKB/TrEMBL
Pfam OB_Dis3 UniProtKB/TrEMBL
  RNB UniProtKB/TrEMBL
  Rrp44_CSD1 UniProtKB/TrEMBL
  Rrp44_S1 UniProtKB/TrEMBL
PROSITE RIBONUCLEASE_II UniProtKB/TrEMBL
SMART RNB UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
UniProt G5AN84 ENTREZGENE, UniProtKB/TrEMBL