Wnt1 (Wnt family member 1) - Rat Genome Database

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Pathways
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Gene: Wnt1 (Wnt family member 1) Heterocephalus glaber
Analyze
Symbol: Wnt1
Name: Wnt family member 1
RGD ID: 18917942
Description: ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein domain specific binding (inferred); INVOLVED IN animal organ regeneration (ortholog); branching involved in ureteric bud morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); atherosclerosis (ortholog); breast cancer (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Proto-oncogene protein Wnt-1; proto-oncogene Wnt-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,209,699 - 3,212,606 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248163,209,605 - 3,212,969 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
astrocyte-dopaminergic neuron signaling  (IEA)
bone development  (IEA)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell fate commitment  (IEA)
cell population proliferation  (IEA,ISO)
cell proliferation in midbrain  (IEA)
cell-cell signaling  (IEA)
cellular response to peptide hormone stimulus  (ISO)
central nervous system morphogenesis  (IEA)
cerebellum development  (IEA)
cerebellum formation  (IEA)
diencephalon development  (IEA,ISO)
dopaminergic neuron differentiation  (IEA)
embryonic axis specification  (IEA)
embryonic brain development  (IEA)
fat cell differentiation  (IEA,ISO)
forebrain anterior/posterior pattern specification  (IEA,ISO)
hematopoietic stem cell proliferation  (IEA,ISO)
hepatocyte differentiation  (ISO)
inner ear morphogenesis  (IEA,ISO)
metencephalon development  (IEA,ISO)
midbrain development  (IEA,ISO)
midbrain dopaminergic neuron differentiation  (IEA)
midbrain-hindbrain boundary development  (IEA,ISO)
midbrain-hindbrain boundary maturation during brain development  (IEA,ISO)
myoblast fusion  (IEA,ISO)
myotube differentiation  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of BMP signaling pathway  (IEA)
negative regulation of cell differentiation  (IEA)
negative regulation of cell-cell adhesion  (IEA)
negative regulation of cell-substrate adhesion  (IEA)
negative regulation of cellular senescence  (IEA)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
negative regulation of ubiquitin-dependent protein catabolic process  (IEA,ISO)
neurogenesis  (IEA)
neuron differentiation  (IEA)
neuron fate commitment  (IEA,ISO)
neuron fate determination  (IEA,ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of dermatome development  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of hematopoietic stem cell proliferation  (IEA,ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (IEA)
positive regulation of lamellipodium assembly  (IEA)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
response to wounding  (IEA)
signal transduction in response to DNA damage  (IEA)
Spemann organizer formation  (IEA)
spinal cord association neuron differentiation  (IEA,ISO)
T cell differentiation in thymus  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,209,699 - 3,212,606 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248163,209,605 - 3,212,969 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
WNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,978,322 - 48,982,620 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,978,322 - 48,982,620 (+)EnsemblGRCh38hg38GRCh38
GRCh371249,372,105 - 49,376,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,658,503 - 47,662,746 (+)NCBINCBI36Build 36hg18NCBI36
Build 341247,658,502 - 47,662,746NCBI
Celera1248,167,028 - 48,171,188 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,403,758 - 46,407,918 (+)NCBIHuRef
CHM1_11249,338,028 - 49,342,188 (+)NCBICHM1_1
T2T-CHM13v2.01248,940,505 - 48,944,803 (+)NCBIT2T-CHM13v2.0
Wnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,687,738 - 98,691,711 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,687,738 - 98,691,718 (+)EnsemblGRCm39 Ensembl
GRCm381598,789,857 - 98,793,830 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,789,857 - 98,793,837 (+)EnsemblGRCm38mm10GRCm38
MGSCv371598,620,288 - 98,624,261 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,617,891 - 98,621,864 (+)NCBIMGSCv36mm8
Celera15100,939,306 - 100,943,279 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.65NCBI
Wnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,817,558 - 131,821,605 (+)NCBIGRCr8
mRatBN7.27129,938,604 - 129,942,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,938,604 - 129,942,651 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,745,620 - 131,749,666 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,971,174 - 133,975,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,883,687 - 133,887,733 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,464,999 - 140,469,046 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,464,999 - 140,469,046 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,975,118 - 114,979,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,557,836 - 137,561,883 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7126,427,473 - 126,431,520 (+)NCBICelera
Cytogenetic Map7q36NCBI
Wnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,797,060 - 7,811,167 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,797,063 - 7,811,142 (+)NCBIChiLan1.0ChiLan1.0
WNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21045,202,480 - 45,206,764 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11245,199,231 - 45,203,539 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,767,839 - 39,772,460 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,648,413 - 40,652,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,648,413 - 40,652,583 (-)Ensemblpanpan1.1panPan2
WNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,588,151 - 5,592,254 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,574,940 - 5,592,060 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,665,906 - 40,669,560 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,639,156 - 5,642,810 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,639,162 - 5,643,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,603,082 - 5,606,734 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,593,278 - 5,596,931 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,058,211 - 41,061,867 (+)NCBIUU_Cfam_GSD_1.0
Wnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,379,465 - 66,383,960 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,780,882 - 6,785,358 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365126,781,001 - 6,785,358 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,010,786 - 15,014,998 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,010,607 - 15,015,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,420,829 - 15,425,219 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,217,402 - 45,222,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,219,027 - 45,222,017 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037200,920,985 - 200,926,676 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000005970   ⟹   ENSHGLP00000005896
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248163,209,699 - 3,212,606 (-)Ensembl
RefSeq Acc Id: XM_004863055   ⟹   XP_004863112
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248163,209,605 - 3,212,969 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004863112 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB00546 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000005896
Reference Protein Sequences
RefSeq Acc Id: XP_004863112   ⟸   XM_004863055
- UniProtKB: G5AU35 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000005896   ⟸   ENSHGLT00000005970


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004305 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000005970 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt1 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
NCBI Gene Wnt1 ENTREZGENE
PANTHER PROTO-ONCOGENE WNT-1 UniProtKB/TrEMBL
  WNT RELATED UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT1PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt G5AU35 ENTREZGENE, UniProtKB/TrEMBL