Nsmce2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Nsmce2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase) Heterocephalus glaber
Analyze
Symbol: Nsmce2
Name: NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
RGD ID: 18917056
Description: ENCODES a protein that exhibits ligase activity (inferred); metal ion binding (inferred); SUMO ligase activity (inferred); INVOLVED IN double-strand break repair via nonhomologous end joining (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Developmental Disabilities (ortholog); hereditary spastic paraplegia 8 (ortholog); FOUND IN chromosome, telomeric region (inferred); nuclear body (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 SUMO-protein ligase NSE2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473529,913,423 - 30,151,922 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473529,915,007 - 30,166,564 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nsmce2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473529,913,423 - 30,151,922 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473529,915,007 - 30,166,564 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NSMCE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388125,091,860 - 125,367,120 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8125,091,679 - 125,367,120 (+)EnsemblGRCh38hg38GRCh38
GRCh378126,104,102 - 126,379,362 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368126,173,277 - 126,448,544 (+)NCBINCBI36Build 36hg18NCBI36
Celera8122,293,246 - 122,568,218 (+)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8121,427,877 - 121,703,222 (+)NCBIHuRef
CHM1_18126,144,698 - 126,419,607 (+)NCBICHM1_1
T2T-CHM13v2.08126,225,519 - 126,500,604 (+)NCBIT2T-CHM13v2.0
Nsmce2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391559,246,047 - 59,473,538 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1559,246,096 - 59,473,533 (+)EnsemblGRCm39 Ensembl
GRCm381559,374,198 - 59,601,689 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1559,374,247 - 59,601,684 (+)EnsemblGRCm38mm10GRCm38
MGSCv371559,205,753 - 59,433,239 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361559,203,928 - 59,431,364 (+)NCBIMGSCv36mm8
Celera1560,905,217 - 61,133,508 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1525.19NCBI
Nsmce2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8792,825,568 - 93,071,037 (+)NCBIGRCr8
mRatBN7.2790,936,112 - 91,173,435 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl790,936,112 - 91,164,899 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx792,826,087 - 93,044,522 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0795,027,272 - 95,245,732 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0794,854,556 - 95,076,868 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0799,677,295 - 99,900,765 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl799,677,290 - 99,900,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07100,263,539 - 100,486,903 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4796,167,635 - 96,393,594 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1796,201,864 - 96,427,823 (+)NCBI
Celera787,697,871 - 87,919,520 (+)NCBICelera
Cytogenetic Map7q33NCBI
Nsmce2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955461201,764 - 451,776 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955461199,356 - 451,716 (+)NCBIChiLan1.0ChiLan1.0
NSMCE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27142,514,870 - 142,789,089 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18118,026,022 - 118,300,121 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08121,777,986 - 122,052,094 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18124,529,245 - 124,803,354 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8124,529,268 - 124,803,114 (+)Ensemblpanpan1.1panPan2
NSMCE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11323,078,143 - 23,288,302 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1323,078,173 - 23,288,304 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1323,042,326 - 23,261,292 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01323,419,977 - 23,634,235 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1323,420,016 - 23,634,235 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11323,140,666 - 23,355,264 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01323,249,898 - 23,462,275 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01323,492,960 - 23,706,136 (+)NCBIUU_Cfam_GSD_1.0
Nsmce2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530315,021,038 - 15,241,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647022,445,433 - 22,667,559 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647022,447,278 - 22,667,302 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSMCE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl414,358,651 - 14,598,077 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1414,359,323 - 14,598,192 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2414,948,825 - 15,035,641 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NSMCE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18119,679,090 - 119,949,212 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8119,691,106 - 119,949,587 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603920,225,964 - 20,495,843 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000026946   ⟹   ENSHGLP00000026709
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473529,913,423 - 30,151,922 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000026947   ⟹   ENSHGLP00000026710
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473529,969,472 - 30,151,908 (-)Ensembl
RefSeq Acc Id: XM_004837962   ⟹   XP_004838019
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473529,915,007 - 30,166,564 (-)NCBI
RefSeq Acc Id: XM_004837963   ⟹   XP_004838020
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473529,915,007 - 30,117,159 (-)NCBI
RefSeq Acc Id: XM_004837964   ⟹   XP_004838021
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473529,969,170 - 30,166,564 (-)NCBI
RefSeq Acc Id: XM_004837965   ⟹   XP_004838022
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473530,022,841 - 30,166,564 (-)NCBI
RefSeq Acc Id: XM_004837967   ⟹   XP_004838024
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473529,969,181 - 30,166,564 (-)NCBI
RefSeq Acc Id: XM_021252192   ⟹   XP_021107851
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473530,076,980 - 30,166,564 (-)NCBI
RefSeq Acc Id: XM_021252193   ⟹   XP_021107852
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473530,073,900 - 30,166,564 (-)NCBI
RefSeq Acc Id: XR_002392137
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473529,921,707 - 30,166,564 (-)NCBI
RefSeq Acc Id: XR_002392138
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473529,921,707 - 30,166,564 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004838019   ⟸   XM_004837962
- Peptide Label: isoform X1
- UniProtKB: A0A0P6K206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004838020   ⟸   XM_004837963
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004838021   ⟸   XM_004837964
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004838024   ⟸   XM_004837967
- Peptide Label: isoform X7
RefSeq Acc Id: XP_004838022   ⟸   XM_004837965
- Peptide Label: isoform X6
RefSeq Acc Id: XP_021107852   ⟸   XM_021252193
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021107851   ⟸   XM_021252192
- Peptide Label: isoform X4
RefSeq Acc Id: ENSHGLP00000026710   ⟸   ENSHGLT00000026947
RefSeq Acc Id: ENSHGLP00000026709   ⟸   ENSHGLT00000026946


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019000 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026946 ENTREZGENE
  ENSHGLT00000026947 ENTREZGENE
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro Nse2(Mms21) UniProtKB/TrEMBL
  Ubox_domain UniProtKB/TrEMBL
  Znf_MIZ UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report hgl:101707405 UniProtKB/TrEMBL
NCBI Gene Nsmce2 ENTREZGENE
PANTHER E3 SUMO-PROTEIN LIGASE NSE2 UniProtKB/TrEMBL
  PTHR21330 UniProtKB/TrEMBL
Pfam zf-Nse UniProtKB/TrEMBL
PROSITE ZF_SP_RING UniProtKB/TrEMBL
SMART Ubox UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A0P6K206 ENTREZGENE, UniProtKB/TrEMBL