Ptpn23 (protein tyrosine phosphatase non-receptor type 23) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ptpn23 (protein tyrosine phosphatase non-receptor type 23) Heterocephalus glaber
Analyze
Symbol: Ptpn23
Name: protein tyrosine phosphatase non-receptor type 23
RGD ID: 18916583
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN cilium assembly (ortholog); negative regulation of epithelial cell migration (ortholog); positive regulation of adherens junction organization (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); Luscan-Lumish Syndrome (ortholog); FOUND IN ciliary basal body (ortholog); cytoplasm (ortholog); early endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein phosphatase non-receptor type 23
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473073,975,655 - 74,004,572 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473073,975,490 - 74,004,454 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ptpn23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473073,975,655 - 74,004,572 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473073,975,490 - 74,004,454 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PTPN23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38347,381,021 - 47,413,435 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl347,381,011 - 47,413,435 (+)EnsemblGRCh38hg38GRCh38
GRCh37347,422,511 - 47,454,925 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36347,397,495 - 47,429,935 (+)NCBINCBI36Build 36hg18NCBI36
Build 34347,397,538 - 47,429,935NCBI
Celera347,361,133 - 47,393,570 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef347,465,405 - 47,497,882 (+)NCBIHuRef
CHM1_1347,372,731 - 47,405,159 (+)NCBICHM1_1
T2T-CHM13v2.0347,397,442 - 47,429,855 (+)NCBIT2T-CHM13v2.0
Ptpn23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,214,152 - 110,237,278 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,214,150 - 110,237,281 (-)EnsemblGRCm39 Ensembl
GRCm389110,385,084 - 110,408,210 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,385,082 - 110,408,213 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,287,593 - 110,310,714 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,230,249 - 110,253,380 (-)NCBIMGSCv36mm8
Celera9110,114,048 - 110,137,187 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.92NCBI
Ptpn23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,239,213 - 119,261,675 (-)NCBIGRCr8
mRatBN7.28110,360,804 - 110,383,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,360,804 - 110,383,271 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,976,297 - 115,998,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,175,487 - 114,198,014 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,018,278 - 112,040,806 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08118,628,777 - 118,651,238 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8118,628,777 - 118,651,238 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,972,419 - 117,994,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,761,478 - 114,768,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,780,932 - 114,788,379 (-)NCBI
Celera8109,646,218 - 109,668,775 (-)NCBICelera
Cytogenetic Map8q32NCBI
Ptpn23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542024,869,894 - 24,897,102 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542024,869,737 - 24,897,196 (-)NCBIChiLan1.0ChiLan1.0
PTPN23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2247,335,386 - 47,370,508 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1347,340,727 - 47,375,277 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0347,280,706 - 47,314,268 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1348,378,367 - 48,413,739 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl348,379,810 - 48,413,488 (+)Ensemblpanpan1.1panPan2
PTPN23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12041,485,959 - 41,511,250 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2041,485,195 - 41,587,003 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2041,402,362 - 41,427,545 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02041,968,876 - 41,994,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,968,884 - 41,994,053 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,210,842 - 41,236,027 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02041,611,994 - 41,637,374 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,892,621 - 41,917,798 (-)NCBIUU_Cfam_GSD_1.0
Ptpn23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118201,526,967 - 201,575,339 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365961,094,205 - 1,124,712 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365961,094,285 - 1,124,483 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1330,190,755 - 30,253,113 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11330,190,659 - 30,252,980 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21333,423,209 - 33,483,647 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,788,927 - 8,821,566 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl228,788,961 - 8,821,316 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041158,318,824 - 158,351,484 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000016522   ⟹   ENSHGLP00000016353
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473073,975,655 - 74,004,572 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000016523   ⟹   ENSHGLP00000016354
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473073,975,658 - 74,004,361 (-)Ensembl
RefSeq Acc Id: XM_004834976   ⟹   XP_004835033
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473073,975,490 - 74,004,361 (-)NCBI
RefSeq Acc Id: XM_013072515   ⟹   XP_012927969
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473073,975,490 - 74,004,454 (-)NCBI
RefSeq Acc Id: XM_021256789   ⟹   XP_021112448
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473073,975,655 - 74,004,451 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004835033 (Get FASTA)   NCBI Sequence Viewer  
  XP_012927969 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112448 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016353
GenBank Protein JAN97042 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_012927969   ⟸   XM_013072515
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JTQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004835033   ⟸   XM_004834976
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JTQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112448   ⟸   XM_021256789
- Peptide Label: isoform X3
- UniProtKB: A0A0P6JTQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000016354   ⟸   ENSHGLT00000016523
RefSeq Acc Id: ENSHGLP00000016353   ⟸   ENSHGLT00000016522


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011720 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000016522 ENTREZGENE
Gene3D-CATH 1.25.40.280 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
  alix/aip1 in complex with the ypdl late domain UniProtKB/TrEMBL
  alix/aip1 like domains UniProtKB/TrEMBL
InterPro ALIX_V_dom UniProtKB/TrEMBL
  BRO1-like UniProtKB/TrEMBL
  BRO1_dom UniProtKB/TrEMBL
  BRO1_sf UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
NCBI Gene Ptpn23 ENTREZGENE
PANTHER PTHR23030 UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23 UniProtKB/TrEMBL
Pfam ALIX_LYPXL_bnd UniProtKB/TrEMBL
  BRO1 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE BRO1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART BRO1 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A0P6JTQ3 ENTREZGENE, UniProtKB/TrEMBL