Sh2b1 (SH2B adaptor protein 1) - Rat Genome Database

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Gene: Sh2b1 (SH2B adaptor protein 1) Heterocephalus glaber
Analyze
Symbol: Sh2b1
Name: SH2B adaptor protein 1
RGD ID: 18915530
Description: ENCODES a protein that exhibits signaling adaptor activity (inferred); transmembrane receptor protein tyrosine kinase adaptor activity (inferred); INVOLVED IN cell motility (ortholog); lamellipodium assembly (ortholog); positive regulation of mitotic nuclear division (ortholog); PARTICIPATES IN leptin system pathway; ASSOCIATED WITH Brody myopathy (ortholog); chromosome 16p11.2 deletion syndrome, 220-kb (ortholog); chromosome 16p11.2 deletion syndrome, 593-kb (ortholog); FOUND IN plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SH2B adapter protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478212,888,817 - 12,897,707 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478212,888,818 - 12,897,773 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Sh2b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478212,888,817 - 12,897,707 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478212,888,818 - 12,897,773 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SH2B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,846,606 - 28,874,205 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,846,600 - 28,874,212 (+)EnsemblGRCh38hg38GRCh38
GRCh371628,857,927 - 28,885,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,782,815 - 28,793,027 (+)NCBINCBI36Build 36hg18NCBI36
Celera1627,829,836 - 27,840,291 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1626,742,418 - 26,752,871 (+)NCBIHuRef
CHM1_11629,886,916 - 29,897,372 (+)NCBICHM1_1
T2T-CHM13v2.01629,127,175 - 29,154,707 (+)NCBIT2T-CHM13v2.0
Sh2b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,066,165 - 126,075,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,066,166 - 126,074,596 (-)EnsemblGRCm39 Ensembl
GRCm387126,466,993 - 126,476,650 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,466,994 - 126,475,424 (-)EnsemblGRCm38mm10GRCm38
MGSCv377133,610,508 - 133,618,644 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,258,144 - 126,264,159 (-)NCBIMGSCv36mm8
Celera7126,319,559 - 126,327,690 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.06NCBI
Sh2b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,479,211 - 190,492,030 (-)NCBIGRCr8
mRatBN7.21181,048,622 - 181,057,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,048,623 - 181,056,579 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,379,202 - 189,387,169 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,565,281 - 196,573,248 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,253,186 - 189,261,106 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01197,878,839 - 197,888,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1197,878,840 - 197,886,759 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01204,857,973 - 204,867,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1178,707,989 - 178,715,895 (-)NCBICelera
Cytogenetic Map1q36NCBI
Sh2b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,583,415 - 6,592,452 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,583,415 - 6,592,690 (-)NCBIChiLan1.0ChiLan1.0
SH2B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21831,886,951 - 31,913,957 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11636,704,473 - 36,731,390 (-)NCBINHGRI_mPanPan1
PanPan1.11629,233,705 - 29,261,072 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1629,249,597 - 29,263,334 (+)Ensemblpanpan1.1panPan2
SH2B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,370,881 - 18,380,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,371,832 - 18,380,962 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,950,137 - 19,959,175 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,507,858 - 18,516,906 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,507,815 - 18,516,904 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,307,240 - 18,316,447 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,222,112 - 18,231,023 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,538,095 - 18,547,144 (+)NCBIUU_Cfam_GSD_1.0
Sh2b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344123,742,367 - 123,750,916 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,840,190 - 11,848,780 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,840,227 - 11,849,742 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH2B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,524,820 - 18,543,135 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,533,282 - 18,543,133 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,718,536 - 18,728,408 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SH2B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,197,483 - 26,208,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,196,778 - 26,207,398 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,406,643 - 3,417,685 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000018077   ⟹   ENSHGLP00000017900
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478212,888,817 - 12,895,288 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000018078   ⟹   ENSHGLP00000017901
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478212,889,497 - 12,897,707 (-)Ensembl
RefSeq Acc Id: XM_013076371   ⟹   XP_012931825
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,889,457 - 12,896,425 (-)NCBI
RefSeq Acc Id: XM_013076374   ⟹   XP_012931828
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,889,457 - 12,896,426 (-)NCBI
RefSeq Acc Id: XM_013076380   ⟹   XP_012931834
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,896,427 (-)NCBI
RefSeq Acc Id: XM_021237380   ⟹   XP_021093039
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,897,327 (-)NCBI
RefSeq Acc Id: XM_021237381   ⟹   XP_021093040
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,896,885 (-)NCBI
RefSeq Acc Id: XM_021237382   ⟹   XP_021093041
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,897,327 (-)NCBI
RefSeq Acc Id: XM_021237383   ⟹   XP_021093042
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,896,969 (-)NCBI
RefSeq Acc Id: XM_021237384   ⟹   XP_021093043
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,896,427 (-)NCBI
RefSeq Acc Id: XM_021237385   ⟹   XP_021093044
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,896,461 (-)NCBI
RefSeq Acc Id: XM_021237386   ⟹   XP_021093045
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,897,327 (-)NCBI
RefSeq Acc Id: XM_021237387   ⟹   XP_021093046
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,897,773 (-)NCBI
RefSeq Acc Id: XM_021237388   ⟹   XP_021093047
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,897,326 (-)NCBI
RefSeq Acc Id: XM_021237390   ⟹   XP_021093049
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,896,897 (-)NCBI
RefSeq Acc Id: XM_021237391   ⟹   XP_021093050
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478212,888,818 - 12,896,781 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021093046   ⟸   XM_021237387
- Peptide Label: isoform X2
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093041   ⟸   XM_021237382
- Peptide Label: isoform X1
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093045   ⟸   XM_021237386
- Peptide Label: isoform X2
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093039   ⟸   XM_021237380
- Peptide Label: isoform X1
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093047   ⟸   XM_021237388
- Peptide Label: isoform X2
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093042   ⟸   XM_021237383
- Peptide Label: isoform X2
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093049   ⟸   XM_021237390
- Peptide Label: isoform X2
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093040   ⟸   XM_021237381
- Peptide Label: isoform X1
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093050   ⟸   XM_021237391
- Peptide Label: isoform X2
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093044   ⟸   XM_021237385
- Peptide Label: isoform X2
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093043   ⟸   XM_021237384
- Peptide Label: isoform X3
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012931834   ⟸   XM_013076380
- Peptide Label: isoform X1
- UniProtKB: G5BRD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012931828   ⟸   XM_013076374
- Peptide Label: isoform X5
RefSeq Acc Id: XP_012931825   ⟸   XM_013076371
- Peptide Label: isoform X4
RefSeq Acc Id: ENSHGLP00000017901   ⟸   ENSHGLT00000018078
RefSeq Acc Id: ENSHGLP00000017900   ⟸   ENSHGLT00000018077


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012826 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000018077 ENTREZGENE
  ENSHGLT00000018078 ENTREZGENE
Gene3D-CATH 6.10.140.110 UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
  SH2 domain UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Phe_ZIP UniProtKB/TrEMBL
  Phe_ZIP_sf UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH2B UniProtKB/TrEMBL
  SH2B1_SH2 UniProtKB/TrEMBL
NCBI Gene Sh2b1 ENTREZGENE
PANTHER SH2B ADAPTER PROTEIN UniProtKB/TrEMBL
  SH2B ADAPTER PROTEIN 1 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  Phe_ZIP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  Phenylalanine zipper UniProtKB/TrEMBL
  SH2 domain UniProtKB/TrEMBL
UniProt G5BRD6 ENTREZGENE, UniProtKB/TrEMBL