Pgam5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase) - Rat Genome Database

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Gene: Pgam5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase) Heterocephalus glaber
Analyze
Symbol: Pgam5
Name: PGAM family member 5, mitochondrial serine/threonine protein phosphatase
RGD ID: 18914224
Description: ENCODES a protein that exhibits GTPase activator activity (ortholog); phosphatase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN necroptotic process (ortholog); negative regulation of cold-induced thermogenesis (ortholog); PARTICIPATES IN mitochondrial autophagy pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); FOUND IN mitochondrial inner membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein phosphatase PGAM5, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474728,078,368 - 28,085,437 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474728,078,138 - 28,084,920 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Pgam5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474728,078,368 - 28,085,437 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474728,078,138 - 28,084,920 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PGAM5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812132,710,842 - 132,722,734 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12132,710,819 - 132,722,734 (+)EnsemblGRCh38hg38GRCh38
GRCh3712133,287,428 - 133,299,320 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612131,797,509 - 131,805,825 (+)NCBINCBI36Build 36hg18NCBI36
Celera12132,987,362 - 133,009,550 (+)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12130,043,032 - 130,078,592 (+)NCBIHuRef
CHM1_112133,107,383 - 133,119,182 (+)NCBICHM1_1
T2T-CHM13v2.012132,759,704 - 132,771,989 (+)NCBIT2T-CHM13v2.0
Pgam5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,407,001 - 110,417,765 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5110,406,996 - 110,417,779 (-)EnsemblGRCm39 Ensembl
GRCm385110,259,135 - 110,269,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,259,130 - 110,269,913 (-)EnsemblGRCm38mm10GRCm38
MGSCv375110,688,154 - 110,698,918 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365110,499,457 - 110,510,184 (-)NCBIMGSCv36mm8
Celera5107,382,715 - 107,393,630 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.43NCBI
Pgam5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,069,023 - 52,076,131 (+)NCBIGRCr8
mRatBN7.21246,409,324 - 46,416,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,409,369 - 46,416,420 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,585,056 - 47,592,113 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01248,190,483 - 48,197,540 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01247,251,009 - 47,258,066 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,467,417 - 52,474,533 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,467,450 - 52,474,511 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,202,823 - 54,210,153 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,555,416 - 46,562,477 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11246,422,347 - 46,429,409 (+)NCBI
Celera1247,965,707 - 47,972,769 (+)NCBICelera
Cytogenetic Map12q16NCBI
Pgam5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955482356,863 - 363,862 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955482356,863 - 363,666 (-)NCBIChiLan1.0ChiLan1.0
PGAM5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210140,814,495 - 140,831,151 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112140,814,741 - 140,827,668 (+)NCBINHGRI_mPanPan1
PGAM5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126406,871 - 414,874 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26407,174 - 414,860 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha26448,802 - 456,805 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.026464,504 - 472,485 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl26464,505 - 485,472 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.126405,826 - 413,824 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.026492,873 - 500,882 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.026424,108 - 432,107 (-)NCBIUU_Cfam_GSD_1.0
PGAM5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1422,773,136 - 22,780,720 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11422,773,135 - 22,780,904 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PGAM5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111128,053,176 - 128,064,030 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11128,053,795 - 128,065,720 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037116,802,167 - 116,811,028 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000024368   ⟹   ENSHGLP00000024149
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474728,078,368 - 28,085,437 (+)Ensembl
RefSeq Acc Id: XM_004844031   ⟹   XP_004844088
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474728,078,138 - 28,084,920 (+)NCBI
RefSeq Acc Id: XM_004844032   ⟹   XP_004844089
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474728,078,409 - 28,084,920 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004844088 (Get FASTA)   NCBI Sequence Viewer  
  XP_004844089 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA98717 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000024149
Reference Protein Sequences
RefSeq Acc Id: XP_004844088   ⟸   XM_004844031
- Peptide Label: isoform X1
- UniProtKB: G5ANV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004844089   ⟸   XM_004844032
- Peptide Label: isoform X2
- UniProtKB: G5ANV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000024149   ⟸   ENSHGLT00000024368


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017212 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000024368 ENTREZGENE
Gene3D-CATH 3.40.50.1240 UniProtKB/TrEMBL
InterPro His_Pase_superF_clade-1 UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/TrEMBL
KEGG Report hgl:101721089 UniProtKB/TrEMBL
NCBI Gene Pgam5 ENTREZGENE
PANTHER PHOSPHOGLYCERATE MUTASE-RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam His_Phos_1 UniProtKB/TrEMBL
SMART PGAM UniProtKB/TrEMBL
Superfamily-SCOP SSF53254 UniProtKB/TrEMBL
UniProt G5ANV7 ENTREZGENE, UniProtKB/TrEMBL