Iqsec2 (IQ motif and Sec7 domain ArfGEF 2) - Rat Genome Database

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Gene: Iqsec2 (IQ motif and Sec7 domain ArfGEF 2) Heterocephalus glaber
Analyze
Symbol: Iqsec2
Name: IQ motif and Sec7 domain ArfGEF 2
RGD ID: 18912587
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN modulation of chemical synaptic transmission (ortholog); positive regulation of long-term synaptic depression (ortholog); positive regulation of synapse assembly (ortholog); ASSOCIATED WITH Atkin Syndrome (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN glutamatergic synapse (ortholog); photoreceptor ribbon synapse (ortholog); postsynaptic density membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: IQ motif and Sec7 domain 2; IQ motif and SEC7 domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624909460,626 - 565,133 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624909462,724 - 564,989 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Iqsec2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624909460,626 - 565,133 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624909462,724 - 564,989 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IQSEC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X53,225,813 - 53,321,350 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX53,225,828 - 53,321,350 (-)EnsemblGRCh38hg38GRCh38
GRCh37X53,262,058 - 53,350,548 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,278,783 - 53,327,521 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX57,091,294 - 57,179,759 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX50,327,195 - 50,414,951 (-)NCBIHuRef
CHM1_1X53,252,281 - 53,340,767 (-)NCBICHM1_1
T2T-CHM13v2.0X52,512,100 - 52,607,614 (-)NCBIT2T-CHM13v2.0
Iqsec2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X150,927,179 - 151,008,233 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX150,927,193 - 151,008,232 (+)EnsemblGRCm39 Ensembl
GRCm38X152,144,183 - 152,225,237 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX152,144,268 - 152,225,236 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X148,578,811 - 148,659,779 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X147,519,725 - 147,565,952 (+)NCBIMGSCv36mm8
MGSCv36X129,187,494 - 129,233,721 (+)NCBIMGSCv36mm8
CeleraX132,285,132 - 132,286,052 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Iqsec2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,734,202 - 24,816,566 (+)NCBIGRCr8
mRatBN7.2X21,254,799 - 21,337,179 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX21,254,914 - 21,336,584 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX18,720,062 - 18,802,376 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,321,193 - 21,403,511 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X21,820,482 - 21,902,802 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X22,212,137 - 22,293,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX22,212,132 - 22,294,402 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X64,286,343 - 64,367,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,651,275 - 41,733,435 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX21,517,185 - 21,598,702 (+)NCBICelera
Cytogenetic MapXq13NCBI
Iqsec2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955475284,168 - 369,400 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955475285,977 - 369,380 (-)NCBIChiLan1.0ChiLan1.0
IQSEC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X54,625,041 - 54,720,577 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X54,628,648 - 54,724,175 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X45,447,977 - 45,535,836 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X53,557,847 - 53,604,744 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX53,557,563 - 53,644,737 (-)Ensemblpanpan1.1panPan2
IQSEC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X44,861,813 - 44,915,011 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX44,872,888 - 44,913,704 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX36,516,736 - 36,595,958 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X45,308,027 - 45,386,860 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX45,306,847 - 45,386,965 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X44,803,229 - 44,882,038 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X45,252,874 - 45,331,684 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X45,320,205 - 45,399,024 (-)NCBIUU_Cfam_GSD_1.0
Iqsec2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X37,871,074 - 37,963,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936751210,761 - 294,399 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936751210,800 - 294,358 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQSEC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,011,388 - 46,094,817 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,011,386 - 46,094,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X51,511,372 - 51,566,645 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IQSEC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X49,363,569 - 49,452,872 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX49,364,909 - 49,387,050 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660863,317,401 - 3,407,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000001391   ⟹   ENSHGLP00000001349
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624909460,626 - 565,133 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000001392   ⟹   ENSHGLP00000001350
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624909460,626 - 565,133 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000001393   ⟹   ENSHGLP00000001351
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624909462,736 - 564,980 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000001394   ⟹   ENSHGLP00000001352
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624909465,019 - 564,881 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000001395   ⟹   ENSHGLP00000001353
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624909465,019 - 510,937 (-)Ensembl
RefSeq Acc Id: XM_004873507   ⟹   XP_004873564
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909462,724 - 564,988 (-)NCBI
RefSeq Acc Id: XM_004873509   ⟹   XP_004873566
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909464,837 - 564,989 (-)NCBI
RefSeq Acc Id: XM_013068778   ⟹   XP_012924232
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909462,724 - 564,989 (-)NCBI
RefSeq Acc Id: XM_013068780   ⟹   XP_012924234
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909462,724 - 564,988 (-)NCBI
RefSeq Acc Id: XM_013068781   ⟹   XP_012924235
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909462,725 - 511,019 (-)NCBI
RefSeq Acc Id: XM_013068782   ⟹   XP_012924236
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909462,725 - 511,019 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_012924232   ⟸   XM_013068778
- Peptide Label: isoform X1
RefSeq Acc Id: XP_012924234   ⟸   XM_013068780
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004873564   ⟸   XM_004873507
- Peptide Label: isoform X2
RefSeq Acc Id: XP_012924236   ⟸   XM_013068782
- Peptide Label: isoform X5
RefSeq Acc Id: XP_012924235   ⟸   XM_013068781
- Peptide Label: isoform X4
RefSeq Acc Id: XP_004873566   ⟸   XM_004873509
- Peptide Label: isoform X6
RefSeq Acc Id: ENSHGLP00000001352   ⟸   ENSHGLT00000001394
RefSeq Acc Id: ENSHGLP00000001350   ⟸   ENSHGLT00000001392
RefSeq Acc Id: ENSHGLP00000001349   ⟸   ENSHGLT00000001391
RefSeq Acc Id: ENSHGLP00000001353   ⟸   ENSHGLT00000001395
RefSeq Acc Id: ENSHGLP00000001351   ⟸   ENSHGLT00000001393


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001050 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000001391 ENTREZGENE
  ENSHGLT00000001392 ENTREZGENE
  ENSHGLT00000001393 ENTREZGENE
  ENSHGLT00000001394 ENTREZGENE
NCBI Gene Iqsec2 ENTREZGENE