Ric8a (RIC8 guanine nucleotide exchange factor A) - Rat Genome Database

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Gene: Ric8a (RIC8 guanine nucleotide exchange factor A) Heterocephalus glaber
Analyze
Symbol: Ric8a
Name: RIC8 guanine nucleotide exchange factor A
RGD ID: 18905420
Description: ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); basement membrane organization (ortholog); cell migration involved in gastrulation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: resistance to inhibitors of cholinesterase 8 homolog A; Synembryn-A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476622,234,484 - 22,240,940 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476622,234,484 - 22,240,874 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Ric8a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476622,234,484 - 22,240,940 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476622,234,484 - 22,240,874 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RIC8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811207,708 - 215,113 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11207,708 - 215,113 (+)EnsemblGRCh38hg38GRCh38
GRCh3711207,708 - 215,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611198,530 - 205,113 (+)NCBINCBI36Build 36hg18NCBI36
Celera11343,749 - 350,332 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef1128,547 - 35,130 (+)NCBIHuRef
CHM1_111207,204 - 213,787 (+)NCBICHM1_1
T2T-CHM13v2.011248,906 - 256,311 (+)NCBIT2T-CHM13v2.0
Ric8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,437,310 - 140,443,644 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,436,870 - 140,444,285 (+)EnsemblGRCm39 Ensembl
GRCm387140,857,397 - 140,863,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,856,957 - 140,864,372 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,043,296 - 148,049,630 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367140,708,717 - 140,715,051 (+)NCBIMGSCv36mm8
Celera7140,649,681 - 140,656,018 (+)NCBICelera
Cytogenetic Map7F4NCBI
cM Map786.06NCBI
Ric8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,364,796 - 205,371,102 (+)NCBIGRCr8
mRatBN7.21195,935,162 - 195,941,469 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,935,349 - 195,941,467 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,287,626 - 204,293,929 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,414,534 - 211,420,838 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,088,386 - 204,094,690 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,606,599 - 213,612,905 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,606,599 - 213,612,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,531,948 - 220,538,536 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,014,483 - 201,020,790 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,164,714 - 201,170,146 (+)NCBI
Celera1193,579,108 - 193,585,413 (+)NCBICelera
Cytogenetic Map1q41NCBI
Ric8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,827,004 - 11,833,162 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,827,004 - 11,833,495 (-)NCBIChiLan1.0ChiLan1.0
RIC8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,574,819 - 2,582,645 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1111,730,133 - 1,738,008 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011203,317 - 210,135 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111248,881 - 255,274 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11248,880 - 255,269 (+)Ensemblpanpan1.1panPan2
RIC8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,363,031 - 25,368,645 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,362,875 - 25,368,378 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,012,985 - 25,018,594 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01825,889,581 - 25,895,184 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1825,889,427 - 25,902,180 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,457,590 - 25,463,198 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,102,367 - 25,107,976 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,715,214 - 25,720,830 (+)NCBIUU_Cfam_GSD_1.0
Ric8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494757,369 - 62,720 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493688856,811 - 63,776 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493688857,212 - 62,722 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIC8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,215 - 39,360 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1232,135 - 37,682 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22162,187,001 - 162,192,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RIC8A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,597 - 25,398 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl119,013 - 25,473 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,033,852 - 97,040,311 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000026540   ⟹   ENSHGLP00000026305
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476622,234,484 - 22,240,940 (-)Ensembl
RefSeq Acc Id: XM_004851766   ⟹   XP_004851823
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476622,234,484 - 22,240,874 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004851823 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB00632 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026305
Reference Protein Sequences
RefSeq Acc Id: XP_004851823   ⟸   XM_004851766
- UniProtKB: G5AUC1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000026305   ⟸   ENSHGLT00000026540


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018718 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026540 ENTREZGENE
Gene3D-CATH Leucine-rich Repeat Variant UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Gua_nucleotide_exch_fac_Ric8 UniProtKB/TrEMBL
  Synembryn UniProtKB/TrEMBL
NCBI Gene Ric8a ENTREZGENE
PANTHER SYNEMBRYN UniProtKB/TrEMBL
  SYNEMBRYN-A UniProtKB/TrEMBL
Pfam Ric8 UniProtKB/TrEMBL
PRINTS SYNEMBRYN UniProtKB/TrEMBL
Superfamily-SCOP ARM repeat UniProtKB/TrEMBL
UniProt G5AUC1 ENTREZGENE, UniProtKB/TrEMBL