Casc3 (CASC3 exon junction complex subunit) - Rat Genome Database

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Gene: Casc3 (CASC3 exon junction complex subunit) Heterocephalus glaber
Analyze
Symbol: Casc3
Name: CASC3 exon junction complex subunit
RGD ID: 18900377
Description: ENCODES a protein that exhibits enzyme binding (ortholog); identical protein binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN intracellular mRNA localization (ortholog); mRNA splicing, via spliceosome (ortholog); regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (ortholog); ASSOCIATED WITH hypertrophic cardiomyopathy 25 (ortholog); FOUND IN exon-exon junction complex (ortholog); nuclear membrane (ortholog); ribonucleoprotein complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cancer susceptibility 3; cancer susceptibility candidate 3; protein CASC3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,046,880 - 3,068,840 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,048,800 - 3,068,432 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Casc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,046,880 - 3,068,840 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,048,800 - 3,068,432 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CASC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,140,537 - 40,172,171 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,140,318 - 40,172,171 (+)EnsemblGRCh38hg38GRCh38
GRCh371738,296,790 - 38,328,424 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,550,033 - 35,581,957 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,550,101 - 35,581,950NCBI
Celera1734,957,057 - 34,988,947 (+)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1734,089,810 - 34,121,621 (+)NCBIHuRef
CHM1_11738,532,213 - 38,564,116 (+)NCBICHM1_1
T2T-CHM13v2.01741,004,421 - 41,036,050 (+)NCBIT2T-CHM13v2.0
Casc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,700,634 - 98,724,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,695,731 - 98,724,640 (+)EnsemblGRCm39 Ensembl
GRCm381198,809,808 - 98,833,807 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,804,905 - 98,833,814 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,671,122 - 98,695,121 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,620,995 - 98,649,897 (+)NCBIMGSCv36mm8
Celera11108,464,578 - 108,488,942 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.68NCBI
Casc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,264,157 - 84,286,639 (+)NCBIGRCr8
mRatBN7.21083,769,014 - 83,788,966 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,769,001 - 83,788,966 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,712,889 - 88,732,839 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,210,964 - 88,230,913 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,603,666 - 83,623,621 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,724,534 - 86,744,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,724,427 - 86,745,927 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,520,779 - 86,540,730 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,581,850 - 87,602,528 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,596,219 - 87,616,898 (+)NCBI
Celera1082,516,863 - 82,536,588 (+)NCBICelera
Cytogenetic Map10q31NCBI
Casc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,784,915 - 14,806,773 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,784,915 - 14,804,191 (+)NCBIChiLan1.0ChiLan1.0
CASC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,778,328 - 24,815,889 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,673,341 - 26,709,474 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,116,864 - 17,148,752 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,339,060 - 17,370,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,339,060 - 17,370,076 (-)Ensemblpanpan1.1panPan2
CASC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,403,139 - 22,427,475 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,405,336 - 22,427,426 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,875,423 - 21,899,758 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,195,932 - 23,220,306 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,195,933 - 23,220,256 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,969,725 - 21,994,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,228,453 - 22,252,787 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,353,409 - 22,377,760 (-)NCBIUU_Cfam_GSD_1.0
Casc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,796,874 - 21,823,263 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,251,110 - 15,278,732 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,251,132 - 15,278,264 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,199,228 - 22,221,499 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,199,227 - 22,221,573 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,565,028 - 22,574,442 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,001,923 - 66,037,025 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,000,434 - 66,037,093 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,906,206 - 36,939,903 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000017114   ⟹   ENSHGLP00000016943
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247953,046,880 - 3,068,840 (-)Ensembl
RefSeq Acc Id: XM_004859453   ⟹   XP_004859510
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247953,048,800 - 3,068,430 (-)NCBI
RefSeq Acc Id: XM_021240361   ⟹   XP_021096020
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247953,048,800 - 3,068,432 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004859510 (Get FASTA)   NCBI Sequence Viewer  
  XP_021096020 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016943
Reference Protein Sequences
RefSeq Acc Id: XP_021096020   ⟸   XM_021240361
- Peptide Label: isoform X2
- UniProtKB: G5BRV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004859510   ⟸   XM_004859453
- Peptide Label: isoform X1
- UniProtKB: G5BRV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000016943   ⟸   ENSHGLT00000017114


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012117 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000017114 ENTREZGENE
InterPro Btz_dom UniProtKB/TrEMBL
NCBI Gene Casc3 ENTREZGENE
PANTHER PROTEIN CASC3 UniProtKB/TrEMBL
  PROTEIN CASC3 UniProtKB/TrEMBL
Pfam Btz UniProtKB/TrEMBL
SMART Btz UniProtKB/TrEMBL
UniProt G5BRV7 ENTREZGENE, UniProtKB/TrEMBL