Mmachc (metabolism of cobalamin associated C) - Rat Genome Database

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Gene: Mmachc (metabolism of cobalamin associated C) Heterocephalus glaber
Analyze
Symbol: Mmachc
Name: metabolism of cobalamin associated C
RGD ID: 18899700
Description: ENCODES a protein that exhibits cobalamin binding (inferred); cyanocobalamin reductase (cyanide-eliminating) activity (inferred); demethylase activity (inferred); INVOLVED IN cobalamin metabolic process (inferred); demethylation (inferred); glutathione metabolic process (inferred); ASSOCIATED WITH atypical hemolytic-uremic syndrome (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); developmental and epileptic encephalopathy (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; Methylmalonic aciduria and homocystinuria type C protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249061,398,724 - 1,409,311 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249061,398,666 - 1,404,709 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Mmachc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249061,398,724 - 1,409,311 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249061,398,666 - 1,404,709 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MMACHC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38145,500,300 - 45,513,382 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl145,500,300 - 45,513,382 (+)EnsemblGRCh38hg38GRCh38
GRCh37145,965,972 - 45,979,054 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,738,443 - 45,749,326 (+)NCBINCBI36Build 36hg18NCBI36
Celera144,249,947 - 44,260,829 (+)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef144,077,989 - 44,088,405 (+)NCBIHuRef
CHM1_1146,083,117 - 46,094,004 (+)NCBICHM1_1
T2T-CHM13v2.0145,372,667 - 45,385,751 (+)NCBIT2T-CHM13v2.0
Mmachc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,559,631 - 116,565,582 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,559,476 - 116,565,603 (-)EnsemblGRCm39 Ensembl
GRCm384116,702,434 - 116,708,385 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,702,279 - 116,708,406 (-)EnsemblGRCm38mm10GRCm38
MGSCv374116,375,039 - 116,380,990 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364116,200,367 - 116,206,253 (-)NCBIMGSCv36mm8
Celera4115,436,428 - 115,442,379 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.29NCBI
Mmachc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,403,094 - 135,409,285 (-)NCBIGRCr8
mRatBN7.25130,166,056 - 130,172,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,166,451 - 130,172,601 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,792,463 - 132,798,604 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,547,064 - 134,553,205 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,569,472 - 134,575,613 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,555,587 - 135,561,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,555,565 - 135,561,914 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,351,762 - 139,357,898 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,995,231 - 137,001,367 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15137,001,103 - 137,006,588 (-)NCBI
Celera5128,693,619 - 128,699,745 (-)NCBICelera
Cytogenetic Map5q35NCBI
Mmachc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,772,420 - 12,780,612 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546412,774,018 - 12,780,612 (-)NCBIChiLan1.0ChiLan1.0
MMACHC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21181,295,944 - 181,308,711 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,437,231 - 180,450,202 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,802,724 - 44,811,893 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,160,364 - 46,171,672 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,160,364 - 46,171,662 (+)Ensemblpanpan1.1panPan2
MMACHC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,857,236 - 14,863,211 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,857,231 - 14,863,113 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,978,374 - 14,984,360 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01515,012,610 - 15,018,557 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1515,012,957 - 15,018,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,809,847 - 14,815,842 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,877,398 - 14,883,398 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,949,428 - 14,955,416 (-)NCBIUU_Cfam_GSD_1.0
Mmachc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,803,821 - 60,816,704 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,636,245 - 26,641,486 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,636,277 - 26,641,486 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMACHC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,860,785 - 165,865,642 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,860,888 - 165,865,674 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26153,266,917 - 153,271,703 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMACHC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,279,028 - 87,289,444 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,279,254 - 87,289,490 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603329,672,896 - 29,682,539 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000001350   ⟹   ENSHGLP00000001308
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249061,398,724 - 1,409,311 (+)Ensembl
RefSeq Acc Id: XM_004872927   ⟹   XP_004872984
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249061,398,666 - 1,404,709 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004872984 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA99751 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001308
  ENSHGLP00000058535
  ENSHGLP00100007472
Reference Protein Sequences
RefSeq Acc Id: XP_004872984   ⟸   XM_004872927
- UniProtKB: G5ARW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000001308   ⟸   ENSHGLT00000001350


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001020 Ensembl, ENTREZGENE
  ENSHGLG00000037299 UniProtKB/TrEMBL
  ENSHGLG00100005589 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000001350 ENTREZGENE
  ENSHGLT00000078748 UniProtKB/TrEMBL
  ENSHGLT00100007568 UniProtKB/TrEMBL
InterPro MMACHC UniProtKB/TrEMBL
KEGG Report hgl:101709397 UniProtKB/TrEMBL
NCBI Gene Mmachc ENTREZGENE
PANTHER CYANOCOBALAMIN REDUCTASE / ALKYLCOBALAMIN DEALKYLASE UniProtKB/TrEMBL
  PTHR31457 UniProtKB/TrEMBL
Pfam MMACHC UniProtKB/TrEMBL
UniProt G5ARW2 ENTREZGENE, UniProtKB/TrEMBL