OTP (orthopedia homeobox) - Rat Genome Database

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Gene: OTP (orthopedia homeobox) Chlorocebus sabaeus
Analyze
Symbol: OTP
Name: orthopedia homeobox
RGD ID: 18796563
Description: ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN dopaminergic neuron differentiation (ortholog); forebrain neuron differentiation (ortholog); hypothalamus cell differentiation (ortholog); ASSOCIATED WITH genetic disease (ortholog); Hermansky-Pudlak syndrome 2 (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN fibrillar center (ortholog); nuclear body (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein orthopedia; LOC103223482
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,861,857 - 71,877,994 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,863,413 - 71,871,769 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604920,700,702 - 20,709,787 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
OTP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,861,857 - 71,877,994 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,863,413 - 71,871,769 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604920,700,702 - 20,709,787 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
OTP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38577,628,712 - 77,638,713 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl577,628,712 - 77,638,713 (-)EnsemblGRCh38hg38GRCh38
GRCh37576,924,537 - 76,934,538 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,960,293 - 76,970,278 (-)NCBINCBI36Build 36hg18NCBI36
Build 34576,960,293 - 76,970,278NCBI
Celera572,812,592 - 72,829,177 (-)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef572,131,689 - 72,141,606 (-)NCBIHuRef
CHM1_1576,358,684 - 76,368,685 (-)NCBICHM1_1
T2T-CHM13v2.0578,111,295 - 78,121,295 (-)NCBIT2T-CHM13v2.0
Otp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,012,144 - 95,021,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,012,110 - 95,021,638 (+)EnsemblGRCm39 Ensembl
GRCm381394,875,636 - 94,885,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1394,875,602 - 94,885,130 (+)EnsemblGRCm38mm10GRCm38
MGSCv371395,645,582 - 95,653,636 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361395,976,326 - 95,984,380 (+)NCBIMGSCv36mm8
Celera1398,492,992 - 98,501,046 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1349.22NCBI
Otp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8227,842,892 - 27,851,093 (+)NCBIGRCr8
mRatBN7.2226,108,158 - 26,116,359 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,108,163 - 26,116,359 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,137,187 - 33,145,388 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,237,421 - 31,245,622 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,062,387 - 26,070,588 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0224,546,393 - 24,554,953 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl224,546,536 - 24,554,683 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0243,712,386 - 43,722,342 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,176,599 - 25,184,585 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,098,409 - 25,098,690 (+)NCBI
Celera222,179,022 - 22,187,133 (+)NCBICelera
Cytogenetic Map2q12NCBI
Otp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542523,350,449 - 23,358,189 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542523,350,449 - 23,358,189 (+)NCBIChiLan1.0ChiLan1.0
OTP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2437,663,671 - 37,674,402 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1535,817,298 - 35,828,029 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0537,667,070 - 37,677,802 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1538,196,327 - 38,206,313 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl538,196,327 - 38,206,313 (+)Ensemblpanpan1.1panPan2
OTP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,063,359 - 29,071,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,064,681 - 29,071,509 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha330,303,340 - 30,311,360 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0328,984,638 - 28,992,657 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl328,984,577 - 28,992,657 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1328,921,217 - 28,929,236 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0328,899,793 - 28,907,811 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,230,596 - 29,238,610 (+)NCBIUU_Cfam_GSD_1.0
Otp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213185,222,332 - 185,232,174 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365495,626,799 - 5,636,556 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365495,626,799 - 5,636,556 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl286,528,348 - 86,537,527 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1286,529,293 - 86,566,414 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2288,136,843 - 88,145,104 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Otp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248692,089,873 - 2,098,064 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248692,089,886 - 2,098,061 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 2 11 2
Below cutoff 13 6 15

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000013398   ⟹   ENSCSAP00000011397
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl471,863,413 - 71,871,769 (-)Ensembl
RefSeq Acc Id: XM_037982126   ⟹   XP_037838054
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604920,700,702 - 20,709,787 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037838054 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011397.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000011397   ⟸   ENSCSAT00000013398
RefSeq Acc Id: XP_037838054   ⟸   XM_037982126


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015302 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013398.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  HTH_motif UniProtKB/TrEMBL
  OAR_dom UniProtKB/TrEMBL
KEGG Report csab:103223482 UniProtKB/TrEMBL
NCBI Gene OTP ENTREZGENE
PANTHER HOMEOBOX PROTEIN ORTHOPEDIA UniProtKB/TrEMBL
  HOMEOBOX PROTEIN ORTHOPEDIA UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
  OAR UniProtKB/TrEMBL
PRINTS HTHREPRESSR UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  OAR UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A0D9RS08_CHLSB UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-09 OTP  orthopedia homeobox  LOC103223482  orthopedia homeobox  Symbol and/or name change 5135510 APPROVED
2020-12-08 LOC103223482  orthopedia homeobox  OTP  orthopedia homeobox  Symbol and/or name change 5135510 APPROVED