TBX21 (T-box transcription factor 21) - Rat Genome Database

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Gene: TBX21 (T-box transcription factor 21) Chlorocebus sabaeus
Analyze
Symbol: TBX21
Name: T-box transcription factor 21
RGD ID: 18789983
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN obsolete cellular response to organic substance (ortholog); positive regulation of gene expression (ortholog); positive regulation of isotype switching to IgG isotypes (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-27 signaling pathway; ASSOCIATED WITH aspirin-induced respiratory disease (ortholog); asthma (ortholog); Asthma and Nasal Polyps (ortholog); FOUND IN neuronal cell body (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: T-box 21; T-box transcription factor TBX21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11668,131,258 - 68,145,579 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1668,131,536 - 68,144,415 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607739,176,675 - 39,190,489 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TBX21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11668,131,258 - 68,145,579 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1668,131,536 - 68,144,415 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607739,176,675 - 39,190,489 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TBX21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381747,733,236 - 47,746,122 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1747,733,236 - 47,746,122 (+)EnsemblGRCh38hg38GRCh38
GRCh371745,810,602 - 45,823,488 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,165,609 - 43,178,484 (+)NCBINCBI36Build 36hg18NCBI36
Build 341743,165,608 - 43,178,484NCBI
Celera1742,263,420 - 42,276,290 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1741,179,683 - 41,192,556 (+)NCBIHuRef
CHM1_11745,875,536 - 45,888,411 (+)NCBICHM1_1
T2T-CHM13v2.01748,595,046 - 48,607,933 (+)NCBIT2T-CHM13v2.0
Tbx21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391196,988,833 - 97,006,157 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1196,988,897 - 97,006,157 (-)EnsemblGRCm39 Ensembl
GRCm381197,098,007 - 97,115,331 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1197,098,071 - 97,115,331 (-)EnsemblGRCm38mm10GRCm38
MGSCv371196,959,321 - 96,976,645 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361196,914,161 - 96,931,370 (-)NCBIMGSCv36mm8
Celera11106,750,749 - 106,768,081 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1160.95NCBI
Tbx21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81082,578,751 - 82,595,253 (-)NCBIGRCr8
mRatBN7.21082,082,322 - 82,098,831 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,082,322 - 82,098,831 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1087,030,758 - 87,047,326 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01086,528,813 - 86,545,383 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01081,921,417 - 81,937,988 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01085,032,799 - 85,049,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1085,032,799 - 85,049,331 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01084,822,665 - 84,839,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41085,817,743 - 85,834,178 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11085,832,581 - 85,865,421 (-)NCBI
Celera1080,842,416 - 80,858,935 (-)NCBICelera
Cytogenetic Map10q31NCBI
Tbx21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545113,315,859 - 13,325,937 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545113,315,237 - 13,317,888 (-)NCBIChiLan1.0ChiLan1.0
TBX21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21917,354,255 - 17,369,752 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11719,321,328 - 19,335,352 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0179,791,008 - 9,803,894 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1179,973,343 - 9,988,131 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl179,973,920 - 9,985,660 (-)Ensemblpanpan1.1panPan2
TBX21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1924,077,752 - 24,086,560 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl924,077,761 - 24,086,261 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha923,543,406 - 23,555,259 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0924,869,329 - 24,881,229 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl924,869,329 - 24,881,632 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1923,639,751 - 23,651,595 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0923,901,069 - 23,912,963 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0924,027,863 - 24,039,741 (+)NCBIUU_Cfam_GSD_1.0
Tbx21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560223,516,504 - 23,528,815 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649013,546,292 - 13,558,635 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649013,546,405 - 13,558,635 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1223,996,415 - 24,009,355 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11223,996,415 - 24,009,353 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,867,157 - 23,880,241 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Tbx21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247954,442,188 - 4,453,143 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247954,442,188 - 4,453,544 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 9
Low 2 11 1
Below cutoff 30 28

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008012957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000000599   ⟹   ENSCSAP00000015462
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1668,131,536 - 68,144,415 (+)Ensembl
RefSeq Acc Id: XM_008012957   ⟹   XP_008011148
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11668,131,258 - 68,145,579 (+)NCBI
Vero_WHO_p1.0NW_02366607739,176,675 - 39,190,489 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008011148 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000015462.1
Reference Protein Sequences
RefSeq Acc Id: XP_008011148   ⟸   XM_008012957
- UniProtKB: A0A0D9S3M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000015462   ⟸   ENSCSAT00000000599


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002587 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000599.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  T-box_DNA-bd UniProtKB/TrEMBL
  T-box_sf UniProtKB/TrEMBL
  TF_T-box UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/TrEMBL
KEGG Report csab:103243581 UniProtKB/TrEMBL
NCBI Gene TBX21 ENTREZGENE
PANTHER PTHR11267 UniProtKB/TrEMBL
  T-BOX TRANSCRIPTION FACTOR TBX21 UniProtKB/TrEMBL
Pfam T-box UniProtKB/TrEMBL
PRINTS TBOX UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/TrEMBL
  TBOX_2 UniProtKB/TrEMBL
  TBOX_3 UniProtKB/TrEMBL
SMART TBOX UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
UniProt A0A0D9S3M3 ENTREZGENE, UniProtKB/TrEMBL