CD58 (CD58 molecule) - Rat Genome Database

Name: CD58
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: CD58 (CD58 molecule) Chlorocebus sabaeus

Analyze

Symbol:

CD58

Name:

CD58 molecule

RGD ID:

18789737

Description:

ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN cellular response to tumor necrosis factor (inferred); cellular response to type II interferon (inferred); heterotypic cell-cell adhesion (inferred); ASSOCIATED WITH multiple sclerosis (ortholog); peripheral T-cell lymphoma (ortholog); FOUND IN cell surface (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

lymphocyte function-associated antigen 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	17,152,663 - 17,208,646 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	17,152,777 - 17,208,671 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	19,843,773 - 19,899,845 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

multiple sclerosis (ISO)

peripheral T-cell lymphoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to tumor necrosis factor (IEA)

cellular response to type II interferon (IEA)

heterotypic cell-cell adhesion (IEA)

positive regulation of interleukin-8 production (IEA)

Cellular Component

cell surface (IEA)

membrane (IEA)

Molecular Function

protein binding (ISO)

signaling receptor binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

CD58
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	17,152,663 - 17,208,646 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	17,152,777 - 17,208,671 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	19,843,773 - 19,899,845 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CD58
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	116,514,534 - 116,571,026 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	116,514,534 - 116,571,039 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	117,057,156 - 117,113,648 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	116,858,680 - 116,915,126 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	116,769,198 - 116,825,645	NCBI
Celera	1	115,285,654 - 115,342,230 (-)	NCBI		Celera
Cytogenetic Map	1	p13.1	NCBI
HuRef	1	114,916,575 - 114,973,314 (-)	NCBI		HuRef
CHM1_1	1	117,171,988 - 117,228,583 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	116,524,958 - 116,581,474 (-)	NCBI		T2T-CHM13v2.0

CD58
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	109,167,445 - 109,223,671 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	108,766,913 - 108,823,153 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	85,992,828 - 86,049,066 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	121,045,460 - 121,101,636 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	121,045,460 - 121,101,636 (+)	Ensembl	panpan1.1		panPan2

CD58
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	53,969,207 - 53,997,306 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	53,973,029 - 53,995,672 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	53,616,375 - 53,657,734 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	54,850,583 - 54,891,921 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	17	53,887,761 - 53,929,050 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	53,923,713 - 53,965,058 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	54,497,294 - 54,538,606 (-)	NCBI		UU_Cfam_GSD_1.0

CD58
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	104,169,883 - 104,227,917 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	104,170,827 - 104,225,029 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	114,340,887 - 114,369,778 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	26	15	25
Low	10	5	35
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007977433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007977434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007977436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007977437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000016836 ⟹ ENSCSAP00000016334

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	17,152,777 - 17,208,671 (+)	Ensembl

RefSeq Acc Id:

XM_007977434 ⟹ XP_007975625

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	17,152,680 - 17,208,646 (+)	NCBI
Vero_WHO_p1.0	NW_023666038	19,843,773 - 19,899,845 (+)	NCBI

Sequence:

show sequence

GGCGGGGCGGAGCCCTACTTCTGGCCGCCCGCGTAGGCGGTGCTTGAACTTGGGGCTGCTTGTG
GCTGGGTACTCGCGCAGAGGCGGGCCGGCCAGCCATGGTTGCTGGGAGCGACGCGGGGCGAGCC
CTGGGGGTCCTCGGCGTGATCTGCCTGCTGCGCTGCTTCGGTTTCATCAGCTGTATTTCCCAAC
AAACATATGGTGTTCTGCATAAGAATGTCACTTTCCATGTTCCAAGCAATATACCTTTAACAGA
AATCCTATGGAAAAAACAAAAGGATAAAGTTGCAGAACGGGAAAATTCTGAATTCAGAGCTTTC
TCATCTTTTAAAAATAGGGTTTATTTGGACACTGTGTCAGGTAGCCTCACTATCTACAACTTAA
CATTATCAGATGAAGATGAGTATGAAATGGAATCGCCAAATATTAGCAATACCATGAAGTTCTT
TCTTTATGTGCTTGAGCCTCTTCCATCTCCTACACTAACTTGTGCATTGACTAATGGAAGCATT
GAAGTCCAGTGCATGATACCGGAGCATTACAACACTCATCCACAACTTAACACGTACTCATGGG
ATTGTCCTTTGGAGCAATGTAAACATAACTCAACCCGTATATATTTTAAGATGGAAAATGATCT
TCCACAAAAAGTACAGTGTACTGCTAGCAATCCATTATTTAAAAGAACATCATCCATCATTCCG
GAAACCTGTATCCCGAGCAGTGGTCATTCAAGACAGAGATATGGACTTATACCTGTAGCATTAG
CAGCAGTTGTAACATATGTTGTGCTGTGTGTGCGTGCACTGGTCCAACCCATTCCAGCCTTCCC
TGCATCTTCAGCCTCATGCATAAGCTCCAATTGATTGGTAACAGAAGATGAAGACAACAGCATA
ACAACTAAATTATTTTGAAAACTAAAAAGCCATCTGATTTCTCATTTGAAGAGAAATTTTTGAA
AAATTTCAATTTTCGAAGAACTGTTAGAAATGTAACTTGAAGCAGCTATTTTTTTTTTAAGAAG
AAATACTTACAAACAAAGAACATGCATTAGTTTCAAGTGTCATCAACCTATTATATGACGGGGT
GCTTGCTTTTTTGTCAGTAAATTGTTTTTAGTGATAATAGAGAAACTTTTGTAAATAAATGTAA
ATATGTACATAAGTGA

hide sequence

RefSeq Acc Id:

XM_007977436 ⟹ XP_007975627

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	17,152,663 - 17,208,646 (+)	NCBI
Vero_WHO_p1.0	NW_023666038	19,843,773 - 19,899,845 (+)	NCBI

Sequence:

show sequence

GCGGGCTGCCGGCCCCGGGCGGGGCGGAGCCCTACTTCTGGCCGCCCGCGTAGGCGGTGCTTGA
ACTTGGGGCTGCTTGTGGCTGGGTACTCGCGCAGAGGCGGGCCGGCCAGCCATGGTTGCTGGGA
GCGACGCGGGGCGAGCCCTGGGGGTCCTCGGCGTGATCTGCCTGCTGCGCTGCTTCGGTTTCAT
CAGCTGTATTTCCCAACAAACATATGGTGTTCTGCATAAGAATGTCACTTTCCATGTTCCAAGC
AATATACCTTTAACAGAAATCCTATGGAAAAAACAAAAGGATAAAGTTGCAGAACGGGAAAATT
CTGAATTCAGAGCTTTCTCATCTTTTAAAAATAGGGTTTATTTGGACACTGTGTCAGGTAGCCT
CACTATCTACAACTTAACATTATCAGATGAAGATGAGTATGAAATGGAATCGCCAAATATTAGC
AATACCATGAAGTTCTTTCTTTATGTGCTTGAGCCTCTTCCATCTCCTACACTAACTTGTGCAT
TGACTAATGGAAGCATTGAAGTCCAGTGCATGATACCGGAGCATTACAACACTCATCCACAACT
TAACACGTACTCATGGGATTGTCCTTTGGAGCAATGTAAACATAACTCAACCCGTATATATTTT
AAGATGGAAAATGATCTTCCACAAAAAGTACAGTGTACTGCTAGCAATCCATTATTTAAAAGAA
CATCATCCATCATTCCGGAAACCTGTATCCCGAGCAGTGGTCATTCAAGACAGAGATATGGACT
TATACCTGTAGCATTAGCAGCAGTTGTAACATATGTTGTGCTGTGTGTGCGTGGTACTCGGAAA
TGTGGCAGAAAACCAGACAGAAGCAACTCCAATTGATTGGTAACAGAAGATGAAGACAACAGCA
TAACAACTAAATTATTTTGAAAACTAAAAAGCCATCTGATTTCTCATTTGAAGAGAAATTTTTG
AAAAATTTCAATTTTCGAAGAACTGTTAGAAATGTAACTTGAAGCAGCTATTTTTTTTTTAAGA
AGAAATACTTACAAACAAAGAACATGCATTAGTTTCAAGTGTCATCAACCTATTATATGACGGG
GTGCTTGCTTTTTTGTCAGTAAATTGTTTTTAGTGATAATAGAGAAACTTTTGTAAATAAATGT
AAATATGTACATAAGTGA

hide sequence

RefSeq Acc Id:

XM_007977437 ⟹ XP_007975628

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	17,152,682 - 17,208,646 (+)	NCBI
Vero_WHO_p1.0	NW_023666038	19,843,773 - 19,899,845 (+)	NCBI

Sequence:

show sequence

CGGGGCGGAGCCCTACTTCTGGCCGCCCGCGTAGGCGGTGCTTGAACTTGGGGCTGCTTGTGGC
TGGGTACTCGCGCAGAGGCGGGCCGGCCAGCCATGGTTGCTGGGAGCGACGCGGGGCGAGCCCT
GGGGGTCCTCGGCGTGATCTGCCTGCTGCGCTGCTTCGGTTTCATCAGCTGTATTTCCCAACAA
ACATATGGTGTTCTGCATAAGAATGTCACTTTCCATGTTCCAAGCAATATACCTTTAACAGAAA
TCCTATGGAAAAAACAAAAGGATAAAGTTGCAGAACGGGAAAATTCTGAATTCAGAGCTTTCTC
ATCTTTTAAAAATAGGGTTTATTTGGACACTGTGTCAGGTAGCCTCACTATCTACAACTTAACA
TTATCAGATGAAGATGAGTATGAAATGGAATCGCCAAATATTAGCAATACCATGAAGTTCTTTC
TTTATGTGCTTGAGCCTCTTCCATCTCCTACACTAACTTGTGCATTGACTAATGGAAGCATTGA
AGTCCAGTGCATGATACCGGAGCATTACAACACTCATCCACAACTTAACACGTACTCATGGGAT
TGTCCTTTGGAGCAATGTAAACATAACTCAACCCGTATATATTTTAAGATGGAAAATGATCTTC
CACAAAAAGTACAGTGTACTGCTAGCAATCCATTATTTAAAAGAACATCATCCATCATTCCGGA
AACCTGTATCCCGAGCAGTGGTCATTCAAGACAGAGATATGGACTTATACCTGTAGCATTAGCA
GCAGTTGTAACATATGTTGTGCTGTGTGTGCGTGCTCCAATTGATTGGTAACAGAAGATGAAGA
CAACAGCATAACAACTAAATTATTTTGAAAACTAAAAAGCCATCTGATTTCTCATTTGAAGAGA
AATTTTTGAAAAATTTCAATTTTCGAAGAACTGTTAGAAATGTAACTTGAAGCAGCTATTTTTT
TTTTAAGAAGAAATACTTACAAACAAAGAACATGCATTAGTTTCAAGTGTCATCAACCTATTAT
ATGACGGGGTGCTTGCTTTTTTGTCAGTAAATTGTTTTTAGTGATAATAGAGAAACTTTTGTAA
ATAAATGTAAATATGTACATAAGTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007975625	(Get FASTA)	NCBI Sequence Viewer
	XP_007975627	(Get FASTA)	NCBI Sequence Viewer
	XP_007975628	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000016334.1

RefSeq Acc Id:	XP_007975627 ⟸ XM_007977436
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9S645 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007975625 ⟸ XM_007977434
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9S645 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007975628 ⟸ XM_007977437
- Peptide Label:	isoform X3
- UniProtKB:	A0A0D9S645 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000016334 ⟸ ENSCSAT00000016836

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000001694	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000016836.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
KEGG Report	csab:103224141	UniProtKB/TrEMBL
NCBI Gene	CD58	ENTREZGENE
PANTHER	LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3	UniProtKB/TrEMBL
	SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0A0D9S645	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD