LOC103219558 (serine/threonine-protein kinase SIK1) - Rat Genome Database

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Gene: LOC103219558 (serine/threonine-protein kinase SIK1) Chlorocebus sabaeus
Analyze
Symbol: LOC103219558 (Ensembl: SIK1)
Name: serine/threonine-protein kinase SIK1 (Ensembl:salt inducible kinase 1)
RGD ID: 18787701
Description: ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); protein phosphorylation (ortholog); regulation of sodium ion transport (ortholog); ASSOCIATED WITH autistic disorder (ortholog); cataract 9 multiple types (ortholog); Cold Injury (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: salt inducible kinase 1; SIK1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,204,386 - 87,217,044 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl287,204,357 - 87,216,180 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605415,257,361 - 15,270,116 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC103219558
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,204,386 - 87,217,044 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl287,204,357 - 87,216,180 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605415,257,361 - 15,270,116 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SIK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382143,414,483 - 43,427,131 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2143,414,483 - 43,427,131 (-)EnsemblGRCh38hg38GRCh38
GRCh372144,834,363 - 44,847,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362143,658,823 - 43,671,430 (-)NCBINCBI36Build 36hg18NCBI36
Build 342143,658,826 - 43,671,436NCBI
Celera2129,940,650 - 29,953,256 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2130,202,979 - 30,223,345 (-)NCBIHuRef
CHM1_12144,394,974 - 44,407,557 (-)NCBICHM1_1
T2T-CHM13v2.02141,769,738 - 41,782,385 (-)NCBIT2T-CHM13v2.0
Sik1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391732,063,222 - 32,074,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1732,063,224 - 32,074,778 (-)EnsemblGRCm39 Ensembl
GRCm381731,844,248 - 31,855,804 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,844,250 - 31,855,804 (-)EnsemblGRCm38mm10GRCm38
MGSCv371731,981,195 - 31,992,737 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361731,572,967 - 31,584,494 (-)NCBIMGSCv36mm8
Celera1732,760,486 - 32,771,258 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.25NCBI
Sik1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,947,104 - 9,958,729 (-)NCBIGRCr8
mRatBN7.2209,949,407 - 9,959,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,947,396 - 9,958,991 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2010,650,232 - 10,659,745 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,011,124 - 10,020,639 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,478,619 - 10,488,162 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,670,747 - 10,680,279 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,668,411 - 10,680,283 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02012,845,508 - 12,855,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,282,203 - 10,291,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12010,280,420 - 10,292,014 (-)NCBI
Celera2011,458,458 - 11,467,962 (-)NCBICelera
Cytogenetic Map20p12NCBI
Sik1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540738,739,062 - 38,749,758 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540738,739,062 - 38,749,293 (+)NCBIChiLan1.0ChiLan1.0
SIK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22239,424,080 - 39,439,146 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12134,278,914 - 34,290,144 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02129,675,040 - 29,689,408 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12142,975,914 - 42,987,948 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2142,975,920 - 42,987,948 (-)Ensemblpanpan1.1panPan2
SIK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13137,455,130 - 37,466,829 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3136,610,274 - 36,622,021 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03136,998,123 - 37,010,456 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3136,998,129 - 37,008,807 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13136,867,482 - 36,879,155 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03136,852,129 - 36,863,810 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03137,344,622 - 37,356,464 (-)NCBIUU_Cfam_GSD_1.0
Sik1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497136,683,495 - 36,693,046 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500774,092 - 784,330 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936500774,749 - 784,326 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13206,454,718 - 206,465,807 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113206,454,695 - 206,465,802 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,759,862 - 216,764,885 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sik1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474527,528,929 - 27,539,552 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474527,529,037 - 27,539,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 23
Low 20 37
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007969452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000006028   ⟹   ENSCSAP00000004238
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl287,204,357 - 87,216,180 (-)Ensembl
RefSeq Acc Id: XM_007969452   ⟹   XP_007967643
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1287,204,386 - 87,217,044 (-)NCBI
Vero_WHO_p1.0NW_02366605415,257,361 - 15,270,116 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007967643 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004238.1
Reference Protein Sequences
RefSeq Acc Id: XP_007967643   ⟸   XM_007969452
- UniProtKB: A0A0D9R6J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000004238   ⟸   ENSCSAT00000006028


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007979 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006028.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  SIK UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
KEGG Report csab:103219558 UniProtKB/TrEMBL
NCBI Gene SIK1 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE-RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9R6J9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LOC103219558  serine/threonine-protein kinase SIK1  SIK1  salt inducible kinase 1  Symbol and/or name change 5135510 APPROVED