ITPA (inosine triphosphatase) - Rat Genome Database

Name: ITPA
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: ITPA (inosine triphosphatase) Chlorocebus sabaeus

Analyze

Symbol:

ITPA

Name:

inosine triphosphatase

RGD ID:

18781354

Description:

ENCODES a protein that exhibits dITP diphosphatase activity (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN chromosome organization (ortholog); ITP catabolic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH anemia (ortholog); anodontia (ortholog); Chemotherapy-Induced Febrile Neutropenia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); intracellular membrane-bounded organelle (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

inosine triphosphate pyrophosphatase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	33,873,231 - 33,893,329 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	33,873,339 - 33,893,556 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	10,617,572 - 10,634,540 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute lymphoblastic leukemia (ISO)

anemia (ISO)

anodontia (ISO)

Chemotherapy-Induced Febrile Neutropenia (ISO)

corneal dystrophy (ISO)

developmental and epileptic encephalopathy (ISO)

developmental and epileptic encephalopathy 1 (ISO)

developmental and epileptic encephalopathy 35 (ISO)

early infantile epileptic encephalopathy (ISO)

epilepsy (ISO)

genetic disease (ISO)

hemolytic anemia (ISO)

hepatitis C (ISO)

Huntington's disease-like 1 (ISO)

inherited metabolic disorder (ISO)

Inosine Triphosphatase Deficiency (ISO)

pantothenate kinase-associated neurodegeneration (ISO)

Recurrence (ISO)

rheumatoid arthritis (ISO)

thrombocytopenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromosome organization (IEA,ISO)

deoxyribonucleoside triphosphate catabolic process (IEA)

ITP catabolic process (IEA,ISO)

nucleoside triphosphate catabolic process (IEA)

nucleotide metabolic process (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

intracellular membrane-bounded organelle (IEA)

nucleoplasm (IEA)

Molecular Function

dITP diphosphatase activity (IEA)

hydrolase activity (IEA)

identical protein binding (IEA)

ITP diphosphatase activity (IEA)

metal ion binding (IEA)

nucleoside triphosphate diphosphatase activity (IEA)

nucleotide binding (IEA)

XTP diphosphatase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

azathioprine pharmacodynamics pathway (ISO)

beta-ureidopropionase deficiency pathway (ISO)

dihydropyrimidinase deficiency pathway (ISO)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

mitochondrial neurogastrointestinal encephalopathy syndrome pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

orotic aciduria 1 pathway (ISO)

purine metabolic pathway (ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

pyrimidine metabolic pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ITPA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	33,873,231 - 33,893,329 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	33,873,339 - 33,893,556 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	10,617,572 - 10,634,540 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

ITPA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	3,204,065 - 3,227,449 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	3,208,868 - 3,223,870 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	3,189,322 - 3,208,095 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	3,138,056 - 3,152,506 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	3,138,055 - 3,152,504	NCBI
Celera	20	3,252,018 - 3,266,469 (+)	NCBI		Celera
Cytogenetic Map	20	p13	NCBI
HuRef	20	3,137,390 - 3,152,825 (+)	NCBI		HuRef
CHM1_1	20	3,189,574 - 3,204,578 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	3,234,474 - 3,258,399 (+)	NCBI		T2T-CHM13v2.0

Itpa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	130,506,702 - 130,523,534 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	130,509,530 - 130,523,534 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	130,664,692 - 130,681,614 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	130,667,610 - 130,681,614 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	130,493,577 - 130,507,350 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	130,359,282 - 130,373,055 (+)	NCBI		MGSCv36	mm8
Celera	2	131,892,647 - 131,906,412 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	63.24	NCBI

Itpa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	138,338,549 - 138,350,329 (+)	NCBI		GRCr8
mRatBN7.2	3	117,885,464 - 117,897,247 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	117,885,099 - 117,897,249 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	121,779,700 - 121,791,613 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	130,377,306 - 130,389,249 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	128,035,835 - 128,047,749 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	123,209,611 - 123,221,266 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	123,209,608 - 123,221,269 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	129,707,739 - 129,719,394 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	118,298,330 - 118,310,110 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	116,696,317 - 116,708,064 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

Itpa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	14,107,380 - 14,121,619 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	14,106,786 - 14,121,975 (+)	NCBI	ChiLan1.0	ChiLan1.0

ITPA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	4,175,151 - 4,190,553 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	4,171,972 - 4,187,379 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	3,295,075 - 3,309,546 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	3,056,395 - 3,074,466 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	3,056,395 - 3,070,924 (+)	Ensembl	panpan1.1		panPan2

ITPA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	18,070,980 - 18,081,815 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	18,064,983 - 18,082,163 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	17,899,408 - 17,910,225 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	18,489,683 - 18,500,338 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	18,484,647 - 18,500,667 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	18,083,389 - 18,094,040 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	18,195,716 - 18,206,381 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	18,523,354 - 18,534,007 (-)	NCBI		UU_Cfam_GSD_1.0

Itpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	167,068,324 - 167,080,629 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	15,497,822 - 15,511,992 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	15,499,688 - 15,511,992 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ITPA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	32,455,459 - 32,474,784 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	32,458,351 - 32,474,827 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	36,828,072 - 36,835,384 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Itpa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	4,312,360 - 4,325,825 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	4,312,363 - 4,341,996 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	3	33
Low		17	27
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008019290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008019300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000039	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000011376 ⟹ ENSCSAP00000009450

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	2	33,873,339 - 33,893,556 (+)	Ensembl

RefSeq Acc Id:

XM_008019290 ⟹ XP_008017481

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	2	33,873,321 - 33,893,329 (+)	NCBI
Vero_WHO_p1.0	NW_023666071	10,617,572 - 10,634,540 (-)	NCBI

Sequence:

show sequence

TACTTCCGCCACCAGCCGGAAGTTTTCTGTCGTCACTGGACACCAAGGAGTTTTCGGTGGCTCA
GCTGGGTAACCGGGGCTCACCATGGCGGCCTCATTGGTGGGGAAGAAGATCGTGTTTGTCACGG
GGAACGCCAAGAAGCTGGAGGAGGTCATTCAGATTCTAGGAGATAAGTTTCCATGCACTTTGGT
GGCACAGAAAATTGACCTGCCGGAGTACCAGGGGGAGCCGGATGAGATTTCCATACAGAAATGT
CAGGAGGCAGCTCGCCAGGTACAGGGGCCTGTGCTGGTTGAAGACACCTGTCTGTGCTACAACG
CCCTTGGAGGGCTCCCCGGCCCCTACATAAAGTGGTTTCTGGAGAAGTTAAAGCCTGAAGAGGT
GAAGTCTCACTATGTTGCCCTGGCTGGTCTCAAACTCCTGAGCTCAAGTGACCCACCCACCTTG
GCCTCCCAAAGTGTTGGGATTACAGGTCTCCACCAGCTCCTGGCTGGGTTCGAGGACAAGTCAG
CCTACGCGCTCTGCACGTTTGCACTCAGCACCGGGGACCCAAGCCAGCCCGTGCGCCTGTTCAG
GGGCCGGACTTCGGGCCAGATCGTGGCACCCAGAGGCTGCCGGGACTTTGGCTGGGACCCCTGC
TTTCAGCCTGATGGATATGAGCAGACGTACGCAGAGATGCCTAAGGCGGAGAAGAACGCCGTCT
CCCATCGCTTCCAGGCCCTGCTGGAGCTGCAGGAGTACTTTGGCAGCTTGACTTCTGCGGCTGG
GGGAGGCCTTTCAGGCCAGGGATCTGGGGAGGGCTAGCCTGAAACCTCCTGCATCAGGCAGGCA
CCCCTGGAAGTACTTCCTTTAGGGTTTCCCCTTCCTGGGGGTGTCAAGTAGCCTCACCAGCCTG
TCTGGAGGAGCAGATGGCTCTGCTCTGAGAAACTCTGGGCAAGTGGATGCCATTCTCTTGCCCT
TAGGATTCACTGCTCTCTCCTACAACCTCCAGGCCTGGGATCCTGAAAGGACCTTGGGTGGTAA
AGCTGGACTTGGTGGGAGTGAGGGCTTGGGGAGGAACCATGCAAATCACCTCCCATGTTTTTTA
AATGCAATAAATAACACTTCTGGATGAGA

hide sequence

RefSeq Acc Id:

XM_008019300 ⟹ XP_008017491

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	2	33,873,231 - 33,893,329 (+)	NCBI
Vero_WHO_p1.0	NW_023666071	10,617,572 - 10,634,536 (-)	NCBI

Sequence:

show sequence

TCGAACGCGGAGGGCTATGCCGCCACCGCGAGCCCAGTCGCCCGATACGCGCCTTGGGGTCCGG
GTCCCCTGGCCGGAAACTGAGCCGTTTACTTCCGCCACCAGCCGGAAGTTTTCTGTCGTCACTG
GACACCAAGGAGTTTTCGGTGGCTCAGCTGGGTAACCGGGGCTCACCATGGCGGCCTCATTGGT
GGGGAAGAAGATCGTGTTTGTCACGGGGAACGCCAAGAAGCTGGAGGAGGTCATTCAGATTCTA
GGAGATAAGTTTCCATGCACTTTGGTGGCACAGAAAATTGACCTGCCGGAGTACCAGGGGGAGC
CGGATGAGATTTCCATACAGAAATGTCAGGAGGCAGCTCGCCAGGTACAGGGGCCTGTGCTGGT
TGAAGACACCTGTCTGTGCTACAACGCCCTTGGAGGGCTCCCCGGCCCCTACATAAAGTGGTTT
CTGGAGAAGTTAAAGCCTGAAGGTCTCCACCAGCTCCTGGCTGGGTTCGAGGACAAGTCAGCCT
ACGCGCTCTGCACGTTTGCACTCAGCACCGGGGACCCAAGCCAGCCCGTGCGCCTGTTCAGGGG
CCGGACTTCGGGCCAGATCGTGGCACCCAGAGGCTGCCGGGACTTTGGCTGGGACCCCTGCTTT
CAGCCTGATGGATATGAGCAGACGTACGCAGAGATGCCTAAGGCGGAGAAGAACGCCGTCTCCC
ATCGCTTCCAGGCCCTGCTGGAGCTGCAGGAGTACTTTGGCAGCTTGACTTCTGCGGCTGGGGG
AGGCCTTTCAGGCCAGGGATCTGGGGAGGGCTAGCCTGAAACCTCCTGCATCAGGCAGGCACCC
CTGGAAGTACTTCCTTTAGGGTTTCCCCTTCCTGGGGGTGTCAAGTAGCCTCACCAGCCTGTCT
GGAGGAGCAGATGGCTCTGCTCTGAGAAACTCTGGGCAAGTGGATGCCATTCTCTTGCCCTTAG
GATTCACTGCTCTCTCCTACAACCTCCAGGCCTGGGATCCTGAAAGGACCTTGGGTGGTAAAGC
TGGACTTGGTGGGAGTGAGGGCTTGGGGAGGAACCATGCAAATCACCTCCCATGTTTTTTAAAT
GCAATAAATAACACTTCTGGATGAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008017481	(Get FASTA)	NCBI Sequence Viewer
	XP_008017491	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009450
	ENSCSAP00000009450.1

RefSeq Acc Id:	XP_008017491 ⟸ XM_008019300
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9RLG1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_008017481 ⟸ XM_008019290
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSCSAP00000009450 ⟸ ENSCSAT00000011376

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000013283	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011376.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.950.10	UniProtKB/TrEMBL
InterPro	Ham1p-like	UniProtKB/TrEMBL
	ITPase	UniProtKB/TrEMBL
	ITPase-like_fam	UniProtKB/TrEMBL
NCBI Gene	ITPA	ENTREZGENE
PANTHER	INOSINE TRIPHOSPHATE PYROPHOSPHATASE	UniProtKB/TrEMBL
	PTHR11067	UniProtKB/TrEMBL
Pfam	Ham1p_like	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52972	UniProtKB/TrEMBL
UniProt	A0A0D9RLG1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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