ASCC2 (activating signal cointegrator 1 complex subunit 2) - Rat Genome Database

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Gene: ASCC2 (activating signal cointegrator 1 complex subunit 2) Chlorocebus sabaeus
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Symbol: ASCC2
Name: activating signal cointegrator 1 complex subunit 2
RGD ID: 18746649
Description: ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (inferred); ubiquitin binding (inferred); INVOLVED IN regulation of DNA-templated transcription (inferred); rescue of stalled ribosome (inferred); ribosome disassembly (inferred); ASSOCIATED WITH Breast Cancer, Familial (ortholog); vestibular schwannomatosis (ortholog); FOUND IN cytosolic ribosome (ortholog); DNA repair complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,673,642 - 12,725,268 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1912,673,064 - 12,725,233 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045113,421,058 - 113,472,673 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ASCC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,673,642 - 12,725,268 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1912,673,064 - 12,725,233 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045113,421,058 - 113,472,673 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ASCC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,788,611 - 29,838,274 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,788,609 - 29,838,304 (-)EnsemblGRCh38hg38GRCh38
GRCh372230,184,600 - 30,234,263 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,514,600 - 28,564,254 (-)NCBINCBI36Build 36hg18NCBI36
Build 342228,509,155 - 28,558,808NCBI
Celera2213,984,318 - 14,033,974 (-)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2213,146,838 - 13,196,327 (-)NCBIHuRef
CHM1_12230,143,775 - 30,193,418 (-)NCBICHM1_1
T2T-CHM13v2.02230,251,982 - 30,301,644 (-)NCBIT2T-CHM13v2.0
Ascc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,587,698 - 4,635,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,587,747 - 4,635,699 (+)EnsemblGRCm39 Ensembl
GRCm38114,637,696 - 4,685,699 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,637,747 - 4,685,699 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,537,796 - 4,583,388 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,537,796 - 4,583,388 (+)NCBIMGSCv36mm8
Celera115,138,813 - 5,181,677 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.94NCBI
Ascc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,726,975 - 83,771,312 (+)NCBIGRCr8
mRatBN7.21479,503,449 - 79,547,801 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,503,517 - 79,545,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,934,172 - 83,976,128 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,174,233 - 85,216,197 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,623,865 - 81,665,862 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,873,507 - 84,913,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,876,781 - 84,913,617 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,550,450 - 85,592,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,277,839 - 85,320,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1478,409,997 - 78,452,215 (+)NCBICelera
Cytogenetic Map14q21NCBI
Ascc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,032,194 - 4,077,953 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,032,357 - 4,077,900 (-)NCBIChiLan1.0ChiLan1.0
ASCC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22339,760,257 - 39,810,219 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12242,461,579 - 42,511,511 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02210,832,102 - 10,881,987 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12228,637,041 - 28,686,019 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2228,637,041 - 28,686,003 (-)Ensemblpanpan1.1panPan2
ASCC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,967,880 - 23,009,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,970,222 - 23,004,731 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,838,835 - 22,880,563 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,341,402 - 23,383,094 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,341,404 - 23,383,009 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,051,584 - 23,093,413 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,314,145 - 23,355,874 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,373,924 - 23,415,658 (-)NCBIUU_Cfam_GSD_1.0
Ascc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,118,251 - 112,161,111 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366573,707,721 - 3,752,499 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366573,709,578 - 3,752,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASCC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,797,317 - 46,842,459 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,797,307 - 46,842,479 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,832,165 - 49,879,613 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ascc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247476,105,753 - 6,149,987 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247476,103,219 - 6,150,011 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 20 31
Low 29
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000007679   ⟹   ENSCSAP00000005850
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1912,673,064 - 12,725,233 (-)Ensembl
RefSeq Acc Id: XM_007975354   ⟹   XP_007973545
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11912,673,642 - 12,725,268 (-)NCBI
Vero_WHO_p1.0NW_023666045113,421,067 - 113,472,673 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007975355   ⟹   XP_007973546
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11912,673,642 - 12,725,243 (-)NCBI
Vero_WHO_p1.0NW_023666045113,421,067 - 113,472,673 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007975356   ⟹   XP_007973547
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11912,673,642 - 12,725,243 (-)NCBI
Vero_WHO_p1.0NW_023666045113,421,058 - 113,472,673 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007975357   ⟹   XP_007973548
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11912,673,642 - 12,725,238 (-)NCBI
Vero_WHO_p1.0NW_023666045113,421,086 - 113,472,673 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038007627   ⟹   XP_037863555
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666045113,421,058 - 113,472,673 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007973545 (Get FASTA)   NCBI Sequence Viewer  
  XP_007973546 (Get FASTA)   NCBI Sequence Viewer  
  XP_007973547 (Get FASTA)   NCBI Sequence Viewer  
  XP_007973548 (Get FASTA)   NCBI Sequence Viewer  
  XP_037863555 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005850.1
RefSeq Acc Id: XP_007973545   ⟸   XM_007975354
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RB61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007973547   ⟸   XM_007975356
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RB61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007973546   ⟸   XM_007975355
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RB61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007973548   ⟸   XM_007975357
- Peptide Label: isoform X5
- UniProtKB: A0A0D9RB61 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000005850   ⟸   ENSCSAT00000007679
RefSeq Acc Id: XP_037863555   ⟸   XM_038007627
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RB61 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009592 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007679.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro ASCC2_CUE UniProtKB/TrEMBL
  CUE UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
KEGG Report csab:103223149 UniProtKB/TrEMBL
NCBI Gene ASCC2 ENTREZGENE
PANTHER ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 UniProtKB/TrEMBL
  ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100 UniProtKB/TrEMBL
Pfam CUE UniProtKB/TrEMBL
PROSITE CUE UniProtKB/TrEMBL
SMART CUE UniProtKB/TrEMBL
Superfamily-SCOP SSF46934 UniProtKB/TrEMBL
UniProt A0A0D9RB61 ENTREZGENE, UniProtKB/TrEMBL