ICMT (isoprenylcysteine carboxyl methyltransferase) - Rat Genome Database

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Gene: ICMT (isoprenylcysteine carboxyl methyltransferase) Chlorocebus sabaeus
Analyze
Symbol: ICMT
Name: isoprenylcysteine carboxyl methyltransferase
RGD ID: 18726260
Description: ENCODES a protein that exhibits cAMP response element binding protein binding (ortholog); protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity (ortholog); INVOLVED IN bone mineralization (ortholog); C-terminal protein methylation (ortholog); determination of adult lifespan (ortholog); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); large ribosomal subunit (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein-S-isoprenylcysteine O-methyltransferase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,504,240 - 125,516,749 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,504,325 - 125,515,160 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,609,720 - 29,624,581 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ICMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,504,240 - 125,516,749 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,504,325 - 125,515,160 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,609,720 - 29,624,581 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ICMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816,221,193 - 6,235,964 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16,221,193 - 6,235,972 (-)EnsemblGRCh38hg38GRCh38
GRCh3716,281,253 - 6,296,024 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,203,840 - 6,218,631 (-)NCBINCBI36Build 36hg18NCBI36
Celera15,395,764 - 5,410,546 (-)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,429,524 - 5,444,303 (-)NCBIHuRef
CHM1_116,269,895 - 6,284,684 (-)NCBICHM1_1
T2T-CHM13v2.015,746,837 - 5,761,608 (-)NCBIT2T-CHM13v2.0
Icmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,381,671 - 152,391,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,381,684 - 152,391,578 (+)EnsemblGRCm39 Ensembl
GRCm384152,297,214 - 152,307,126 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,297,227 - 152,307,121 (+)EnsemblGRCm38mm10GRCm38
MGSCv374151,671,460 - 151,681,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364151,141,151 - 151,150,922 (+)NCBIMGSCv36mm8
Celera4154,584,683 - 154,594,454 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map483.02NCBI
Icmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85168,084,487 - 168,097,519 (+)NCBIGRCr8
mRatBN7.25162,804,368 - 162,811,129 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,804,368 - 162,811,128 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,507,381 - 165,514,154 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,328,981 - 167,335,754 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,291,181 - 167,297,954 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,475,270 - 169,482,031 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,475,270 - 169,482,030 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05173,027,895 - 173,035,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,526,961 - 169,533,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,537,360 - 169,543,425 (+)NCBI
Celera5161,035,644 - 161,042,405 (+)NCBICelera
Cytogenetic Map5q36NCBI
Icmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554866,280,125 - 6,289,584 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554866,280,838 - 6,289,584 (+)NCBIChiLan1.0ChiLan1.0
ICMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21221,988,066 - 222,000,998 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,629,440 - 220,644,303 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v014,987,384 - 5,002,213 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.116,242,672 - 6,256,102 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16,246,570 - 6,258,746 (-)Ensemblpanpan1.1panPan2
GPR153
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1560,119,793 - 60,128,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl560,123,054 - 60,149,027 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha560,129,410 - 60,138,127 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0560,335,150 - 60,344,074 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,335,160 - 60,365,596 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,334,692 - 60,343,406 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0560,201,501 - 60,210,215 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,602,948 - 60,611,676 (-)NCBIUU_Cfam_GSD_1.0
ICMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,116,946 - 67,123,810 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1667,116,943 - 67,125,908 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,023,966 - 62,032,925 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Icmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248185,165,876 - 5,174,828 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248185,165,923 - 5,174,761 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 1 53
Low 19 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007980792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000017799   ⟹   ENSCSAP00000017271
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl20125,504,325 - 125,515,160 (+)Ensembl
RefSeq Acc Id: XM_007980792   ⟹   XP_007978983
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120125,504,240 - 125,516,749 (+)NCBI
Vero_WHO_p1.0NW_02366605429,609,720 - 29,624,581 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007978983 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000017271
  ENSCSAP00000017271.1
Reference Protein Sequences
RefSeq Acc Id: XP_007978983   ⟸   XM_007980792
- UniProtKB: A0A0D9S8T2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000017271   ⟸   ENSCSAT00000017799


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000000736 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017799.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1630 UniProtKB/TrEMBL
InterPro ICMT_MeTrfase UniProtKB/TrEMBL
  PPMT_MeTrfase UniProtKB/TrEMBL
KEGG Report csab:103225698 UniProtKB/TrEMBL
NCBI Gene ICMT ENTREZGENE
PANTHER PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE UniProtKB/TrEMBL
  PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE UniProtKB/TrEMBL
Pfam ICMT UniProtKB/TrEMBL
PROSITE SAM_ICMT UniProtKB/TrEMBL
UniProt A0A0D9S8T2 ENTREZGENE, UniProtKB/TrEMBL