ERAP1 (endoplasmic reticulum aminopeptidase 1) - Rat Genome Database

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Gene: ERAP1 (endoplasmic reticulum aminopeptidase 1) Chlorocebus sabaeus
Analyze
Symbol: ERAP1
Name: endoplasmic reticulum aminopeptidase 1
RGD ID: 18725720
Description: ENCODES a protein that exhibits aminopeptidase activity (ortholog); endopeptidase activity (ortholog); interleukin-6 receptor binding (ortholog); INVOLVED IN membrane protein ectodomain proteolysis (ortholog); positive regulation of angiogenesis (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH ankylosing spondylitis (ortholog); Behcet's disease (ortholog); cervix carcinoma (ortholog); FOUND IN endoplasmic reticulum lumen (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1490,591,198 - 90,642,331 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl490,600,690 - 90,637,563 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604939,248,974 - 39,415,702 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ERAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1490,591,198 - 90,642,331 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl490,600,690 - 90,637,563 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604939,248,974 - 39,415,702 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ERAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38596,760,813 - 96,935,854 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl596,760,810 - 96,808,100 (-)EnsemblGRCh38hg38GRCh38
GRCh37596,096,517 - 96,149,848 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36596,122,270 - 96,169,648 (-)NCBINCBI36Build 36hg18NCBI36
Build 34596,122,276 - 96,169,398NCBI
Celera591,980,937 - 92,028,293 (-)NCBICelera
Cytogenetic Map5q15NCBI
HuRef591,286,769 - 91,340,086 (-)NCBIHuRef
CHM1_1595,529,237 - 95,582,553 (-)NCBICHM1_1
T2T-CHM13v2.0597,261,648 - 97,314,923 (-)NCBIT2T-CHM13v2.0
Erap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391374,787,692 - 74,841,321 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1374,787,687 - 74,841,320 (+)EnsemblGRCm39 Ensembl
GRCm381374,639,573 - 74,693,205 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1374,639,568 - 74,693,201 (+)EnsemblGRCm38mm10GRCm38
MGSCv371374,777,320 - 74,829,323 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361375,105,874 - 75,157,877 (+)NCBIMGSCv36mm8
Celera1376,970,386 - 77,021,970 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.48NCBI
Erap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr825,666,337 - 5,705,256 (+)NCBIGRCr8
mRatBN7.223,931,817 - 3,970,735 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl23,931,904 - 3,972,447 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx211,040,964 - 11,079,787 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.029,140,189 - 9,179,011 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.023,777,162 - 3,815,982 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.021,410,877 - 1,449,734 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl21,410,934 - 1,449,733 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.021,381,061 - 1,419,645 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.421,453,878 - 1,492,671 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.121,457,924 - 1,492,670 (+)NCBI
Celera2431,649 - 466,037 (+)NCBICelera
Cytogenetic Map2q11NCBI
Erap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541815,830,371 - 15,859,720 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541815,827,560 - 15,859,720 (+)NCBIChiLan1.0ChiLan1.0
ERAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2492,022,595 - 92,056,016 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1590,176,243 - 90,337,794 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0592,061,414 - 92,119,087 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1597,625,811 - 97,799,499 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl597,641,353 - 97,668,365 (-)Ensemblpanpan1.1panPan2
ERAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1312,879,823 - 12,920,710 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl312,879,477 - 12,919,634 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha314,217,433 - 14,261,168 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0312,760,873 - 12,803,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl312,760,934 - 12,803,102 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1312,721,683 - 12,764,349 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0312,716,755 - 12,760,524 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0312,916,519 - 12,958,941 (+)NCBIUU_Cfam_GSD_1.0
Erap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213168,475,893 - 168,502,935 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365236,661,315 - 6,690,425 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365236,661,119 - 6,686,988 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2103,378,429 - 103,408,759 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12103,378,428 - 103,415,066 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22107,137,501 - 107,167,876 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Erap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474315,408,485 - 15,431,967 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474315,407,217 - 15,442,610 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 33 14 25
Low 3 6 35
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000012404   ⟹   ENSCSAP00000010443
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl490,600,690 - 90,637,563 (-)Ensembl
RefSeq Acc Id: XM_007979101   ⟹   XP_007977292
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1490,608,244 - 90,642,329 (-)NCBI
Vero_WHO_p1.0NW_02366604939,263,107 - 39,297,625 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007979110   ⟹   XP_007977301
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1490,608,244 - 90,642,133 (-)NCBI
Vero_WHO_p1.0NW_02366604939,263,335 - 39,297,577 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007979117   ⟹   XP_007977308
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1490,595,651 - 90,642,331 (-)NCBI
Vero_WHO_p1.0NW_02366604939,248,974 - 39,297,625 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037982226   ⟹   XP_037838154
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604939,263,335 - 39,415,702 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007977292 (Get FASTA)   NCBI Sequence Viewer  
  XP_007977301 (Get FASTA)   NCBI Sequence Viewer  
  XP_007977308 (Get FASTA)   NCBI Sequence Viewer  
  XP_037838154 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010443.1
Reference Protein Sequences
RefSeq Acc Id: XP_007977308   ⟸   XM_007979117
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RPA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007977292   ⟸   XM_007979101
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RPA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007977301   ⟸   XM_007979110
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RPA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000010443   ⟸   ENSCSAT00000012404
RefSeq Acc Id: XP_037838154   ⟸   XM_037982226
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RPA4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014309 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012404.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.390.10 UniProtKB/TrEMBL
  1.25.50.20 UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/TrEMBL
  2.60.40.1910 UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  ERAP1-like_C_dom UniProtKB/TrEMBL
  M1_APN-typ UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/TrEMBL
NCBI Gene ERAP1 ENTREZGENE
PANTHER PROTEASE M1 ZINC METALLOPROTEASE UniProtKB/TrEMBL
  PTHR11533:SF156 UniProtKB/TrEMBL
Pfam ERAP1_C UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/TrEMBL
PRINTS ALADIPTASE UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF63737 UniProtKB/TrEMBL
UniProt A0A0D9RPA4 ENTREZGENE, UniProtKB/TrEMBL