MAST1 (microtubule associated serine/threonine kinase 1) - Rat Genome Database

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Gene: MAST1 (microtubule associated serine/threonine kinase 1) Chlorocebus sabaeus
Analyze
Symbol: MAST1
Name: microtubule associated serine/threonine kinase 1
RGD ID: 18716125
Description: ENCODES a protein that exhibits microtubule binding (ortholog); INVOLVED IN brain development (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 4 (ortholog); alpha-mannosidosis (ortholog); Charcot-Marie-Tooth disease dominant intermediate B (ortholog); FOUND IN membrane (ortholog); neuron projection (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: microtubule-associated serine/threonine-protein kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,516,337 - 11,555,940 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,520,813 - 11,557,680 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,234,240 - 8,273,857 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,516,337 - 11,555,940 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,520,813 - 11,557,680 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,234,240 - 8,273,857 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MAST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,838,515 - 12,874,952 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,833,951 - 12,874,952 (+)EnsemblGRCh38hg38GRCh38
GRCh371912,949,329 - 12,985,766 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,810,348 - 12,846,765 (+)NCBINCBI36Build 36hg18NCBI36
Build 341912,810,347 - 12,846,765NCBI
Celera1912,838,964 - 12,875,474 (+)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,520,853 - 12,557,622 (+)NCBIHuRef
CHM1_11912,949,779 - 12,986,286 (+)NCBICHM1_1
T2T-CHM13v2.01912,963,033 - 12,999,436 (+)NCBIT2T-CHM13v2.0
Mast1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,638,482 - 85,672,811 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,638,532 - 85,663,988 (-)EnsemblGRCm39 Ensembl
GRCm38884,911,853 - 84,946,177 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,911,903 - 84,937,359 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,435,752 - 87,461,252 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,802,010 - 87,827,443 (-)NCBIMGSCv36mm8
Celera889,211,248 - 89,236,672 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.32NCBI
MAST1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,121,271 - 40,149,073 (+)NCBIGRCr8
mRatBN7.21923,216,418 - 23,244,224 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,207,991 - 23,244,235 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,039,319 - 30,067,148 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,693,683 - 30,721,508 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01932,916,362 - 32,944,196 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01926,026,045 - 26,053,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,026,043 - 26,053,762 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01937,001,668 - 37,029,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,872,709 - 24,900,429 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,877,534 - 24,905,253 (+)NCBI
Celera1922,773,769 - 22,801,107 (+)NCBICelera
Cytogenetic Map19q11NCBI
Mast1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,907,630 - 31,939,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,907,660 - 31,935,769 (+)NCBIChiLan1.0ChiLan1.0
MAST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,762,585 - 17,803,695 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,763,146 - 16,804,281 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,395,531 - 12,436,646 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11913,138,344 - 13,179,569 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,138,382 - 13,179,569 (+)Ensemblpanpan1.1panPan2
MAST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,302,037 - 49,329,247 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,302,162 - 49,329,837 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,174,328 - 49,204,624 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,819,006 - 49,849,331 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,818,970 - 49,849,298 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,030,321 - 49,056,711 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,456,807 - 49,486,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,699,148 - 49,729,447 (-)NCBIUU_Cfam_GSD_1.0
Mast1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,411,220 - 208,435,522 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,918,420 - 1,946,087 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,919,191 - 1,943,440 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,153,115 - 66,184,289 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,153,109 - 66,184,303 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,439,126 - 66,447,262 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Mast1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901432,836 - 467,161 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901429,191 - 463,534 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 16 29
Low 16 11 31
Below cutoff 4 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000004596   ⟹   ENSCSAP00000002844
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl611,520,813 - 11,557,680 (+)Ensembl
RefSeq Acc Id: XM_007995429   ⟹   XP_007993620
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1611,516,337 - 11,555,940 (+)NCBI
Vero_WHO_p1.0NW_0236660748,234,240 - 8,273,857 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007995430   ⟹   XP_007993621
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1611,516,344 - 11,555,940 (+)NCBI
Vero_WHO_p1.0NW_0236660748,234,240 - 8,273,857 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007995431   ⟹   XP_007993622
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1611,520,638 - 11,555,940 (+)NCBI
Vero_WHO_p1.0NW_0236660748,234,240 - 8,269,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037992158   ⟹   XP_037848086
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660748,234,240 - 8,273,857 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007993620 (Get FASTA)   NCBI Sequence Viewer  
  XP_007993621 (Get FASTA)   NCBI Sequence Viewer  
  XP_007993622 (Get FASTA)   NCBI Sequence Viewer  
  XP_037848086 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002844.1
Reference Protein Sequences
RefSeq Acc Id: XP_007993620   ⟸   XM_007995429
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R2K5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007993621   ⟸   XM_007995430
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R2K5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007993622   ⟸   XM_007995431
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R2K5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000002844   ⟸   ENSCSAT00000004596
RefSeq Acc Id: XP_037848086   ⟸   XM_037992158
- Peptide Label: isoform X4
- UniProtKB: A0A0D9R2K5 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006558 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004596.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1480.20 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MA_Ser/Thr_Kinase_dom UniProtKB/TrEMBL
  MAST UniProtKB/TrEMBL
  MAST_pre-PK_dom_sf UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene MAST1 ENTREZGENE
PANTHER PTHR24356:SF150 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam DUF1908 UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF140482 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9R2K5 ENTREZGENE, UniProtKB/TrEMBL