NME6 (NME/NM23 nucleoside diphosphate kinase 6) - Rat Genome Database

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Gene: NME6 (NME/NM23 nucleoside diphosphate kinase 6) Chlorocebus sabaeus
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Symbol: NME6
Name: NME/NM23 nucleoside diphosphate kinase 6
RGD ID: 18684111
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleoside diphosphate kinase activity (inferred); INVOLVED IN CTP biosynthetic process (inferred); GTP biosynthetic process (inferred); negative regulation of cell growth (inferred); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrial matrix (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nucleoside diphosphate kinase 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,685,583 - 9,692,993 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,681,953 - 9,692,172 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041157,402,956 - 157,410,607 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NME6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,685,583 - 9,692,993 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,681,953 - 9,692,172 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041157,402,956 - 157,410,607 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NME6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,288,402 - 48,301,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,290,722 - 48,301,685 (-)EnsemblGRCh38hg38GRCh38
GRCh37348,333,807 - 48,342,857 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,310,580 - 48,317,852 (-)NCBINCBI36Build 36hg18NCBI36
Celera348,285,973 - 48,293,245 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,389,609 - 48,396,882 (-)NCBIHuRef
CHM1_1348,287,901 - 48,295,173 (-)NCBICHM1_1
T2T-CHM13v2.0348,316,166 - 48,329,136 (-)NCBIT2T-CHM13v2.0
Nme6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,661,830 - 109,672,042 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9109,661,817 - 109,672,184 (+)EnsemblGRCm39 Ensembl
GRCm389109,832,722 - 109,842,974 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,832,749 - 109,843,116 (+)EnsemblGRCm38mm10GRCm38
MGSCv379109,735,308 - 109,745,475 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369109,690,200 - 109,700,367 (+)NCBIMGSCv36mm8
Celera9109,552,378 - 109,569,972 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.79NCBI
Nme6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,708,092 - 118,717,756 (+)NCBIGRCr8
mRatBN7.28109,832,085 - 109,839,301 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,832,589 - 109,839,301 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,448,071 - 115,454,782 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,647,251 - 113,653,963 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,490,053 - 111,496,765 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,920,912 - 117,928,148 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,920,944 - 117,928,195 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,273,425 - 117,280,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,205,773 - 114,212,486 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,227,550 - 114,231,941 (+)NCBI
Celera8109,122,384 - 109,129,093 (+)NCBICelera
Cytogenetic Map8q32NCBI
Nme6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542024,301,081 - 24,306,493 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542024,301,079 - 24,306,370 (+)NCBIChiLan1.0ChiLan1.0
NME6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,257,219 - 48,270,739 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,261,987 - 48,276,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,206,365 - 48,217,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,290,069 - 49,299,831 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,290,069 - 49,299,831 (-)Ensemblpanpan1.1panPan2
NME6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,769,394 - 40,778,802 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,769,501 - 40,776,496 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,686,890 - 40,694,118 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02041,255,019 - 41,262,246 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,255,055 - 41,262,406 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,495,557 - 40,502,784 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,896,726 - 40,903,952 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,177,530 - 41,184,765 (+)NCBIUU_Cfam_GSD_1.0
Nme6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,328,435 - 63,335,781 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652988,949 - 96,236 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493652988,929 - 96,207 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NME6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,046,948 - 31,053,130 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,048,367 - 31,053,285 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,295,023 - 34,299,910 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nme6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473073,414,798 - 73,419,261 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473073,414,124 - 73,421,161 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 2 21
Low 18 39
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000013999   ⟹   ENSCSAP00000011981
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl229,681,953 - 9,692,172 (-)Ensembl
RefSeq Acc Id: XM_007984099   ⟹   XP_007982290
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1229,685,583 - 9,692,993 (-)NCBI
Vero_WHO_p1.0NW_023666041157,402,956 - 157,410,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007984100   ⟹   XP_007982291
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1229,685,583 - 9,692,902 (-)NCBI
Vero_WHO_p1.0NW_023666041157,402,956 - 157,410,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007984101   ⟹   XP_007982292
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1229,685,583 - 9,692,845 (-)NCBI
Vero_WHO_p1.0NW_023666041157,402,956 - 157,410,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007984102   ⟹   XP_007982293
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1229,685,583 - 9,692,512 (-)NCBI
Vero_WHO_p1.0NW_023666041157,403,419 - 157,410,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007984103   ⟹   XP_007982294
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1229,685,583 - 9,691,962 (-)NCBI
Vero_WHO_p1.0NW_023666041157,403,834 - 157,410,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007984104   ⟹   XP_007982295
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1229,685,583 - 9,692,382 (-)NCBI
Vero_WHO_p1.0NW_023666041157,403,334 - 157,410,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007984105   ⟹   XP_007982296
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1229,685,583 - 9,692,534 (-)NCBI
Vero_WHO_p1.0NW_023666041157,403,419 - 157,410,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038003988   ⟹   XP_037859916
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666041157,403,419 - 157,410,607 (+)NCBI
RefSeq Acc Id: XM_038003990   ⟹   XP_037859918
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666041157,403,419 - 157,410,607 (+)NCBI
RefSeq Acc Id: XP_007982290   ⟸   XM_007984099
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007982291   ⟸   XM_007984100
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007982292   ⟸   XM_007984101
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007982296   ⟸   XM_007984105
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RTP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007982293   ⟸   XM_007984102
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007982295   ⟸   XM_007984104
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RTP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007982294   ⟸   XM_007984103
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000011981   ⟸   ENSCSAT00000013999
RefSeq Acc Id: XP_037859916   ⟸   XM_038003988
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037859918   ⟸   XM_038003990
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RTP2 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015904 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013999.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.141 UniProtKB/TrEMBL
InterPro NDK-like_dom UniProtKB/TrEMBL
  NDK-like_dom_sf UniProtKB/TrEMBL
  NDPk6 UniProtKB/TrEMBL
  Nucleoside_diP_kinase UniProtKB/TrEMBL
  Nucleoside_diP_kinase_AS UniProtKB/TrEMBL
NCBI Gene NME6 ENTREZGENE
PANTHER NUCLEOSIDE DIPHOSPHATE KINASE 6 UniProtKB/TrEMBL
  PTHR46956 UniProtKB/TrEMBL
Pfam NDK UniProtKB/TrEMBL
PRINTS NUCDPKINASE UniProtKB/TrEMBL
PROSITE NDP_KINASES UniProtKB/TrEMBL
SMART NDK UniProtKB/TrEMBL
Superfamily-SCOP SSF54919 UniProtKB/TrEMBL
UniProt A0A0D9RTP2 ENTREZGENE, UniProtKB/TrEMBL