WEE1 (WEE1 G2 checkpoint kinase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: WEE1 (WEE1 G2 checkpoint kinase) Chlorocebus sabaeus
Analyze
Symbol: WEE1
Name: WEE1 G2 checkpoint kinase
RGD ID: 18677321
Description: ENCODES a protein that exhibits ATP binding (inferred); magnesium ion binding (inferred); metal ion binding (inferred); INVOLVED IN establishment of cell polarity (ortholog); microtubule cytoskeleton organization (ortholog); neuron projection morphogenesis (ortholog); ASSOCIATED WITH head and neck squamous cell carcinoma (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: wee1-like protein kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,225,615 - 55,247,112 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,231,292 - 55,245,859 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038152,911,791 - 152,927,857 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleolus  (IEA)
nucleus  (IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
WEE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,225,615 - 55,247,112 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,231,292 - 55,245,859 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038152,911,791 - 152,927,857 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
WEE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,573,670 - 9,589,985 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,573,670 - 9,593,457 (+)EnsemblGRCh38hg38GRCh38
GRCh37119,595,217 - 9,611,532 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,550,916 - 9,567,874 (+)NCBINCBI36Build 36hg18NCBI36
Build 34119,550,915 - 9,567,874NCBI
Celera119,716,710 - 9,732,726 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef119,266,900 - 9,282,930 (+)NCBIHuRef
CHM1_1119,594,205 - 9,610,219 (+)NCBICHM1_1
T2T-CHM13v2.0119,657,890 - 9,674,136 (+)NCBIT2T-CHM13v2.0
Wee1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397109,721,266 - 109,742,506 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7109,721,253 - 109,742,493 (+)EnsemblGRCm39 Ensembl
GRCm387110,122,059 - 110,143,299 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7110,122,046 - 110,143,286 (+)EnsemblGRCm38mm10GRCm38
MGSCv377117,265,573 - 117,286,813 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367109,913,236 - 109,934,463 (+)NCBIMGSCv36mm8
Celera7110,095,829 - 110,117,069 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.7NCBI
Wee1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81173,605,609 - 173,632,450 (+)NCBIGRCr8
mRatBN7.21164,173,681 - 164,197,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,174,779 - 164,197,688 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1172,511,086 - 172,529,507 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,697,089 - 179,715,510 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01172,379,478 - 172,397,737 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,765,228 - 174,790,882 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,767,960 - 174,786,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01181,766,494 - 181,790,794 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,769,797 - 167,788,199 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11167,880,459 - 167,898,861 (+)NCBI
Celera1162,072,157 - 162,090,576 (+)NCBICelera
Cytogenetic Map1q33NCBI
Wee1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541425,281,689 - 25,298,096 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541425,281,725 - 25,299,242 (+)NCBIChiLan1.0ChiLan1.0
WEE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2912,013,281 - 12,029,241 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11111,972,062 - 11,992,213 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0119,706,531 - 9,722,528 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1119,437,847 - 9,452,548 (+)NCBIpanpan1.1PanPan1.1panPan2
WEE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12132,843,263 - 32,862,114 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2132,843,320 - 32,862,130 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2132,410,744 - 32,429,606 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02133,721,937 - 33,740,772 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2133,722,005 - 33,737,604 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12132,985,133 - 33,003,990 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02133,151,707 - 33,170,570 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02133,445,593 - 33,464,455 (+)NCBIUU_Cfam_GSD_1.0
Wee1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494752,539,632 - 52,554,844 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365288,573,497 - 8,588,576 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365288,573,837 - 8,588,988 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WEE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl249,880,435 - 49,894,499 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1249,880,416 - 49,894,509 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,229,796 - 53,243,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Wee1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247661,687,044 - 1,701,785 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247661,687,088 - 1,706,185 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 16 18
Low 20 20 42
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000002556   ⟹   ENSCSAP00000000859
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl155,231,292 - 55,245,859 (-)Ensembl
RefSeq Acc Id: XM_037999722   ⟹   XP_037855650
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038152,911,791 - 152,927,857 (-)NCBI
RefSeq Acc Id: XM_037999723   ⟹   XP_037855651
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038152,912,350 - 152,927,001 (-)NCBI
RefSeq Acc Id: XM_037999724   ⟹   XP_037855652
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038152,912,766 - 152,927,001 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037855650 (Get FASTA)   NCBI Sequence Viewer  
  XP_037855651 (Get FASTA)   NCBI Sequence Viewer  
  XP_037855652 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000000859.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000000859   ⟸   ENSCSAT00000002556
RefSeq Acc Id: XP_037855650   ⟸   XM_037999722
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QWX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037855651   ⟸   XM_037999723
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037855652   ⟸   XM_037999724
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004530 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002556.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Wee1-like_protein_kinase UniProtKB/TrEMBL
KEGG Report csab:103240451 UniProtKB/TrEMBL
NCBI Gene WEE1 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED UniProtKB/TrEMBL
  WEE1-LIKE PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PIRSF Wee1-like_protein_kinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9QWX0 ENTREZGENE, UniProtKB/TrEMBL