DCK (deoxycytidine kinase) - Rat Genome Database

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Gene: DCK (deoxycytidine kinase) Chlorocebus sabaeus
Analyze
Symbol: DCK
Name: deoxycytidine kinase
RGD ID: 18671875
Description: ENCODES a protein that exhibits ATP binding (ortholog); deoxycytidine kinase activity (ortholog); deoxyribonucleoside binding (ortholog); INVOLVED IN deoxycytidine metabolic process (ortholog); PARTICIPATES IN gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; lamivudine pharmacokinetics pathway; FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1719,503,855 - 19,535,355 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl719,504,038 - 19,535,674 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660843,326,990 - 3,358,445 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DCK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1719,503,855 - 19,535,355 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl719,504,038 - 19,535,674 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660843,326,990 - 3,358,445 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DCK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38470,993,649 - 71,030,914 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl470,992,538 - 71,030,914 (+)EnsemblGRCh38hg38GRCh38
GRCh37471,859,366 - 71,896,631 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36472,078,256 - 72,115,477 (+)NCBINCBI36Build 36hg18NCBI36
Build 34472,224,426 - 72,261,648NCBI
Celera469,216,290 - 69,253,648 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef467,664,417 - 67,701,817 (+)NCBIHuRef
CHM1_1471,895,140 - 71,932,501 (+)NCBICHM1_1
T2T-CHM13v2.0474,336,086 - 74,373,339 (+)NCBIT2T-CHM13v2.0
Dck
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39588,912,872 - 88,931,136 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl588,912,855 - 88,931,140 (+)EnsemblGRCm39 Ensembl
GRCm38588,765,013 - 88,783,277 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl588,764,996 - 88,783,281 (+)EnsemblGRCm38mm10GRCm38
MGSCv37589,194,038 - 89,212,302 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36589,839,588 - 89,857,838 (+)NCBIMGSCv36mm8
Celera586,914,328 - 86,932,500 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.96NCBI
Dck
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81419,589,298 - 19,610,326 (-)NCBIGRCr8
mRatBN7.21419,305,218 - 19,326,247 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,305,218 - 19,326,247 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1419,294,940 - 19,315,959 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01420,613,805 - 20,634,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01419,316,197 - 19,337,208 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01420,935,442 - 20,952,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,935,369 - 20,953,095 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,845,716 - 20,863,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,886,700 - 20,904,305 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11420,886,695 - 20,904,305 (-)NCBI
Celera1418,648,191 - 18,665,287 (-)NCBICelera
Cytogenetic Map14p22NCBI
Dck
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554472,031,258 - 2,067,210 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554472,031,851 - 2,067,005 (-)NCBIChiLan1.0ChiLan1.0
DCK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2359,054,071 - 59,094,834 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1459,249,120 - 59,286,370 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0453,193,475 - 53,230,708 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1459,537,350 - 59,574,537 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl459,536,997 - 59,574,537 (-)Ensemblpanpan1.1panPan2
DCK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11360,206,742 - 60,236,338 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1360,205,937 - 60,235,678 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1359,940,643 - 59,971,419 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01361,012,272 - 61,043,696 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1361,011,720 - 61,076,885 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11360,627,511 - 60,658,525 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01360,119,020 - 60,150,439 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01361,266,521 - 61,297,680 (+)NCBIUU_Cfam_GSD_1.0
Dck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528515,366,311 - 15,391,122 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365983,817,994 - 3,843,241 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365983,819,239 - 3,846,692 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1867,706,661 - 67,736,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2871,614,965 - 71,642,025 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Dck
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248902,335,081 - 2,368,653 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248902,335,064 - 2,367,826 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 19 1 45
Low 17 19 15
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007998832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000002882   ⟹   ENSCSAP00000001176
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl719,504,038 - 19,535,674 (+)Ensembl
RefSeq Acc Id: XM_007998832   ⟹   XP_007997023
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1719,503,855 - 19,535,355 (+)NCBI
Vero_WHO_p1.0NW_0236660843,326,990 - 3,358,445 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007997023 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001176.1
Reference Protein Sequences
RefSeq Acc Id: XP_007997023   ⟸   XM_007998832
- UniProtKB: A0A0D9QXT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000001176   ⟸   ENSCSAT00000002882


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004847 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002882.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro DCK/DGK UniProtKB/TrEMBL
  DNK_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report csab:103235762 UniProtKB/TrEMBL
NCBI Gene DCK ENTREZGENE
PANTHER DEOXYCYTIDINE KINASE UniProtKB/TrEMBL
  DEOXYNUCLEOSIDE KINASE UniProtKB/TrEMBL
Pfam dNK UniProtKB/TrEMBL
PIRSF DNK UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9QXT7 ENTREZGENE, UniProtKB/TrEMBL