CYFIP2 (cytoplasmic FMR1 interacting protein 2) - Rat Genome Database

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Gene: CYFIP2 (cytoplasmic FMR1 interacting protein 2) Chlorocebus sabaeus
Analyze
Symbol: CYFIP2
Name: cytoplasmic FMR1 interacting protein 2
RGD ID: 18662204
Description: ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN regulation of postsynapse assembly (ortholog); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 65 (ortholog); Developmental Disabilities (ortholog); epilepsy (ortholog); FOUND IN synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytoplasmic FMR1-interacting protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12359,661,045 - 59,794,717 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2359,661,089 - 59,794,826 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603417,835,766 - 17,969,652 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CYFIP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12359,661,045 - 59,794,717 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2359,661,089 - 59,794,826 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603417,835,766 - 17,969,652 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CYFIP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385157,266,123 - 157,395,594 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5157,266,079 - 157,395,595 (+)EnsemblGRCh38hg38GRCh38
GRCh375156,693,133 - 156,822,602 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365156,625,669 - 156,755,184 (+)NCBINCBI36Build 36hg18NCBI36
Build 345156,628,929 - 156,752,793NCBI
Celera5152,719,640 - 152,849,168 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5151,780,753 - 151,910,647 (+)NCBIHuRef
CHM1_15156,125,748 - 156,255,279 (+)NCBICHM1_1
T2T-CHM13v2.05157,785,054 - 157,914,553 (+)NCBIT2T-CHM13v2.0
Cyfip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391146,084,676 - 46,203,686 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1146,084,677 - 46,203,686 (-)EnsemblGRCm39 Ensembl
GRCm381146,193,849 - 46,312,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,193,850 - 46,312,859 (-)EnsemblGRCm38mm10GRCm38
MGSCv371146,007,360 - 46,125,852 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361146,037,281 - 46,155,773 (-)NCBIMGSCv36mm8
Celera1150,779,500 - 50,898,263 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1127.61NCBI
Cyfip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81031,122,653 - 31,242,440 (-)NCBIGRCr8
mRatBN7.21030,621,318 - 30,741,113 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1030,621,318 - 30,741,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,348,673 - 35,468,277 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0103,887,117 - 4,006,729 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01030,323,472 - 30,442,925 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01031,278,746 - 31,419,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,278,746 - 31,419,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,097,979 - 31,198,028 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,321,000 - 31,443,480 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11031,324,310 - 31,444,535 (-)NCBI
Celera1030,074,331 - 30,193,168 (-)NCBICelera
Cytogenetic Map10q21NCBI
Cyfip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540811,462,837 - 11,588,378 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540811,483,891 - 11,586,628 (+)NCBIChiLan1.0ChiLan1.0
CYFIP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24152,461,545 - 152,591,293 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15150,601,092 - 150,730,844 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05152,667,136 - 152,796,575 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15159,288,779 - 159,418,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5159,292,029 - 159,418,077 (+)Ensemblpanpan1.1panPan2
CYFIP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1452,769,638 - 52,875,080 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl452,743,048 - 52,880,589 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha452,661,797 - 52,785,745 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0453,206,203 - 53,330,066 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1453,032,652 - 53,138,139 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0453,139,468 - 53,263,349 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0453,656,324 - 53,780,306 (-)NCBIUU_Cfam_GSD_1.0
Cyfip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213107,310,615 - 107,431,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365155,759,345 - 5,880,713 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365155,759,940 - 5,880,688 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYFIP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1665,852,588 - 66,001,559 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11665,852,584 - 66,001,576 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21671,707,184 - 71,865,915 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Cyfip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473331,996,423 - 32,115,577 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473331,996,717 - 32,115,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20 18 60
Low 16 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008749   ⟹   ENSCSAP00000006886
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2359,661,089 - 59,794,826 (+)Ensembl
RefSeq Acc Id: XM_008015139   ⟹   XP_008013330
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12359,661,045 - 59,794,717 (+)NCBI
Vero_WHO_p1.0NW_02366603417,835,766 - 17,969,652 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008015141   ⟹   XP_008013332
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12359,661,045 - 59,794,717 (+)NCBI
Vero_WHO_p1.0NW_02366603417,835,783 - 17,969,652 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038005523   ⟹   XP_037861451
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603417,835,783 - 17,969,521 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008013330 (Get FASTA)   NCBI Sequence Viewer  
  XP_008013332 (Get FASTA)   NCBI Sequence Viewer  
  XP_037861451 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006886
  ENSCSAP00000006886.1
Reference Protein Sequences
RefSeq Acc Id: XP_008013330   ⟸   XM_008015139
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008013332   ⟸   XM_008015141
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RE47 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000006886   ⟸   ENSCSAT00000008749
RefSeq Acc Id: XP_037861451   ⟸   XM_038005523
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RE47 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010668 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008749.1 UniProtKB/TrEMBL
InterPro Cytoplasmic_FMR1-int UniProtKB/TrEMBL
  DUF1394 UniProtKB/TrEMBL
NCBI Gene CYFIP2 ENTREZGENE
PANTHER CYTOPLASMIC FMR1-INTERACTING PROTEIN 2 UniProtKB/TrEMBL
  PTHR12195 UniProtKB/TrEMBL
Pfam DUF1394 UniProtKB/TrEMBL
  FragX_IP UniProtKB/TrEMBL
PIRSF FMR1_interacting UniProtKB/TrEMBL
PRINTS CYTOFMRPINTP UniProtKB/TrEMBL
UniProt A0A0D9RE47 ENTREZGENE, UniProtKB/TrEMBL