METTL2A (methyltransferase 2A, tRNA N3-cytidine)

Gene: METTL2A (methyltransferase 2A, tRNA N3-cytidine) Chlorocebus sabaeus

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Symbol:

METTL2A

Name:

methyltransferase 2A, tRNA N3-cytidine

RGD ID:

18639365

Description:

ENCODES a protein that exhibits methyltransferase activity (inferred); RNA methyltransferase activity (inferred); S-adenosylmethionine-dependent methyltransferase activity (inferred); INVOLVED IN tRNA metabolic process (ortholog); tRNA modification (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

methyltransferase 2A, methylcytidine; methyltransferase like 2A; methyltransferase-like protein 2A; tRNA N(3)-methylcytidine methyltransferase METTL2A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	58,828,438 - 58,854,284 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666077	29,466,788 - 29,492,321 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

methylation (IEA)

RNA methylation (IEA)

tRNA metabolic process (ISO)

tRNA methylation (IEA)

tRNA modification (ISO)

tRNA processing (IEA)

Cellular Component

cytoplasm (IEA)

Molecular Function

methyltransferase activity (IEA)

protein binding (ISO)

RNA methyltransferase activity (IEA)

S-adenosylmethionine-dependent methyltransferase activity (IEA)

tRNA (cytidine-3-)-methyltransferase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

METTL2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	58,828,438 - 58,854,284 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666077	29,466,788 - 29,492,321 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

METTL2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	62,423,897 - 62,453,385 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	62,423,875 - 62,453,385 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	60,501,258 - 60,530,746 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	57,854,998 - 57,881,186 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	54,888,315 - 54,914,521 (+)	NCBI		Celera
Cytogenetic Map	17	q23.2	NCBI
HuRef	17	55,867,895 - 55,893,867 (+)	NCBI		HuRef
CHM1_1	17	60,565,596 - 60,591,801 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	63,293,823 - 63,323,315 (+)	NCBI		T2T-CHM13v2.0

Mettl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	105,017,251 - 105,031,972 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	105,017,251 - 105,031,220 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	105,126,425 - 105,141,146 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	105,126,425 - 105,140,394 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	104,987,739 - 105,002,460 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	104,942,577 - 104,956,491 (+)	NCBI		MGSCv36	mm8
Celera	11	116,859,290 - 116,874,015 (+)	NCBI		Celera
Cytogenetic Map	11	E1	NCBI
cM Map	11	68.61	NCBI

Mettl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	90,595,411 - 90,609,234 (+)	NCBI		GRCr8
mRatBN7.2	10	90,095,527 - 90,109,354 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	90,095,527 - 90,119,528 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	95,144,903 - 95,158,717 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	94,608,084 - 94,621,902 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	90,026,012 - 90,039,862 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	93,353,944 - 93,367,769 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	93,354,003 - 93,379,470 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	93,112,426 - 93,126,251 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	94,522,903 - 94,536,622 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	94,537,273 - 94,550,848 (+)	NCBI
Celera	10	88,778,569 - 88,792,395 (+)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

Mettl2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955478	9,263,817 - 9,277,850 (-)	NCBI	ChiLan1.0	ChiLan1.0

METTL2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	78,580,093 - 78,607,567 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	83,397,935 - 83,427,897 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	56,488,631 - 56,515,661 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	30,900,046 - 30,904,284 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

METTL2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	10,645,280 - 10,679,826 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	11,672,841 - 11,689,951 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	12,308,397 - 12,325,751 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	12,308,426 - 12,323,641 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	11,255,049 - 11,272,176 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	16,258,972 - 16,276,148 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	16,263,439 - 16,280,556 (-)	NCBI		UU_Cfam_GSD_1.0

Mettl2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	15,932,166 - 15,947,584 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936541	3,247,046 - 3,262,814 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

METTL2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	12	16,291,721 - 16,308,556 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	16,181,512 - 16,198,586 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Mettl2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624849	6,059,350 - 6,072,198 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	11		21
Low	25	20	39
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008012205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_008012205 ⟹ XP_008010396

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	58,828,438 - 58,854,284 (-)	NCBI
Vero_WHO_p1.0	NW_023666077	29,466,788 - 29,492,321 (-)	NCBI

Sequence:

show sequence

TACCGAAAGTTAAGTGTTTCCGGCTCCGGTGTCATGGCCGGCTCCTACCCTGAAGGTGCGCCTG
CCGTCCTCGCCGAAAAGAGGCAGCAGTTTGGGAACCGGTTCCTGAGCGATCCGGCGCGTGTCTT
CCACCACAATGCCTGGGACAATGTGGAGTGGTCAGAAGAGCAAGCCGCAGCGGCGGAGAGAAAA
GTCCAGGAGAACAGTACCCAGCGGGTGTGCCAGGAGAAACAAGTTGATTATGAGATCAATGCCC
ACAAATACTGGAATAACTTCTACAAAATCCATGAAAATGGGTTTTTCAAGGATAGACATTGGCT
TTTTACCGAATTCCCTGAGCTGGCACCTAGCCAGAATCAAAATCATTTGAAGGATTGGTTCTTG
GAGAACAAGAGGAATGAAGTACCTGAATGTAGAAACAATGAGGATGGACCTAGTTTAATAATGG
AAGAACAACACAAGTGTTCTTCGAAGAGCCTTGAACATAAAACAGAGACACCTCCTGTGGAGGA
GAATGTAACTCAGAAAATTAGTGACCTGGAAATTTGTGCTGATGAGTTTCCTGGATCCTCAGCC
ACCTACCGAATACTGGAGGTTGGTTGTGGTGTGGGAAACACAGTCTTTCCAATTTTACAAACGA
ACAATGACCCAGGACTCTTTGTTTACTGCTGTGATTTTTCTTCCACAGCTATAGAGCTGGTCCA
GACAAATCCAGAATATGATCCTTCACGGTGTTTTGCCTTTGTTCACGACCTGTGTGATGAAGAG
AAGAGTTACCCAGTGCCCAAGGGCAGTCTTGATATTATCATTCTCATATTTGTTCTTTCAGCGA
TTGTTCCAGACAAGATGCAGAAGGCCATCAACAGGCTGAGCAGGCTTCTGAAACCTGGGGGGAT
GCTGCTTCTGCGAGATTACGGCCGCTATGACATGGCTCAGCTTCGGTTTAAAAAAGGTCAGTGT
CTATCTGGAAATTTCTACGTGAGAGGTGATGGAACCAGGGTTTACTTCTTCACACAAGAGGAGC
TGGACACGCTTTTCACCACTGCTGGACTGGAAAAGGTTCAGAACCTGGTGGACCGCCGACTACA
GGTGAACCGAGGGAAGCAACTGACAATGTACCGGGTTTGGATTCAGTGCAAATACTGCAAGCCC
CTTCTGTCCAGCACCAGCTGAGAGGCACCTGCTGCCAAGACGATGCAAAAGCTCATTGTGTTTC
CGGGCTTCTTAAAACACATCTGTAGCCCCAGGCATGGCGGTGCATGTCTGTAATCCCAGCCACT
CAGGAGGCTGAGGCGAGCAGGATCCACTGAACCCAGGAGTCCAGCCTGGGCAAAATAGTGAGAC
CCTGTATCTGAAAGTAATCATAAAAATAAAAAGAATATAAATGAGGTCTTGTTGACATTGGACA
ATTTAGGAATTCAGACTTGAACCTTAAACCTAGAAAAAGTTACTTTGTATCAGGATTCTAACAG
TTATGCTTTCTTTATATTTGTGAAGTCCTTTAAAATATAATTTTCTCAAGTTATTTCTTTGAGA
TCTCAATCTGTCTTAGCATTTTGTAACTAATAACTGAAATTTTATTCAGAGGAACTGTAAACCT
TAAAACACCAATTTATTTCCATGTGAAAAAGTGTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008010396	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000000212.1

RefSeq Acc Id:	XP_008010396 ⟸ XM_008012205
- UniProtKB:	A0A0D9QV23 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000003846	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000001878.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
InterPro	Methyltransf_12	UniProtKB/TrEMBL
	MeTrfase	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
KEGG Report	csab:103243246	UniProtKB/TrEMBL
NCBI Gene	METTL2A	ENTREZGENE
PANTHER	PTHR22809	UniProtKB/TrEMBL
	TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2A-RELATED	UniProtKB/TrEMBL
Pfam	Methyltransf_12	UniProtKB/TrEMBL
PIRSF	Mettl2_prd	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A0A0D9QV23	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-05-30	METTL2A	methyltransferase 2A, tRNA N3-cytidine	METTL2A	methyltransferase 2A, methylcytidine	Symbol and/or name change	5135510	APPROVED
2021-05-26	METTL2A	methyltransferase 2A, methylcytidine	METTL2A	methyltransferase like 2A	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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