KCNK3 (potassium two pore domain channel subfamily K member 3) - Rat Genome Database

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Gene: KCNK3 (potassium two pore domain channel subfamily K member 3) Chlorocebus sabaeus
Analyze
Symbol: KCNK3
Name: potassium two pore domain channel subfamily K member 3
RGD ID: 18634792
Description: ENCODES a protein that exhibits open rectifier potassium channel activity (ortholog); INVOLVED IN cellular response to hypoxia (ortholog); cellular response to zinc ion (ortholog); cochlea development (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Deafness (ortholog); genetic disease (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium channel subfamily K member 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,905,168 - 80,945,972 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,906,608 - 80,945,806 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,201,565 - 31,245,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,905,168 - 80,945,972 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,906,608 - 80,945,806 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,201,565 - 31,245,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
KCNK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,692,722 - 26,733,420 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl226,692,722 - 26,733,420 (+)EnsemblGRCh38hg38GRCh38
GRCh37226,915,590 - 26,956,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,769,123 - 26,806,222 (+)NCBINCBI36Build 36hg18NCBI36
Build 34226,827,269 - 26,864,354NCBI
Celera226,759,188 - 26,800,097 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef226,654,995 - 26,695,894 (+)NCBIHuRef
CHM1_1226,845,436 - 26,883,789 (+)NCBICHM1_1
T2T-CHM13v2.0226,731,837 - 26,774,979 (+)NCBIT2T-CHM13v2.0
Kcnk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,745,514 - 30,782,614 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,745,514 - 30,782,615 (+)EnsemblGRCm39 Ensembl
GRCm38530,588,170 - 30,625,270 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,588,170 - 30,625,271 (+)EnsemblGRCm38mm10GRCm38
MGSCv37530,890,543 - 30,927,643 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,864,751 - 30,901,851 (+)NCBIMGSCv36mm8
Celera528,066,527 - 28,103,716 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.68NCBI
Kcnk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,483,129 - 31,519,061 (-)NCBIGRCr8
mRatBN7.2625,761,487 - 25,799,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,763,228 - 25,799,153 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,055,862 - 26,091,832 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,371,748 - 26,407,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,851,418 - 25,887,323 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,154,274 - 27,190,209 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,151,612 - 27,190,132 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,969,843 - 37,005,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,745,923 - 25,782,144 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,748,881 - 25,785,097 (-)NCBI
Celera625,246,393 - 25,282,199 (-)NCBICelera
Cytogenetic Map6q14NCBI
Kcnk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554698,709,999 - 8,747,467 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554698,710,749 - 8,744,423 (+)NCBIChiLan1.0ChiLan1.0
KCNK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,784,329 - 99,825,272 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,788,296 - 99,829,238 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A26,688,938 - 26,729,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A26,780,475 - 26,819,123 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A26,780,475 - 26,819,123 (+)Ensemblpanpan1.1panPan2
KCNK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,732,779 - 20,771,104 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1720,732,819 - 20,768,730 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,626,715 - 20,665,014 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,054,044 - 21,092,326 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,054,082 - 21,089,962 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11720,740,930 - 20,779,204 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01720,752,294 - 20,790,552 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01720,798,295 - 20,836,548 (+)NCBIUU_Cfam_GSD_1.0
Kcnk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,067,699 - 65,071,786 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,770,103 - 5,772,326 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,767,779 - 5,772,043 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,322,446 - 112,359,212 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,322,446 - 112,359,212 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,337,496 - 119,340,759 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Kcnk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247388,813,644 - 8,848,783 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247388,813,683 - 8,850,744 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 34 18
Low 2 9 38
Below cutoff 8 4

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007971201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000007338   ⟹   ENSCSAP00000005522
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1480,906,608 - 80,945,806 (-)Ensembl
RefSeq Acc Id: XM_007971201   ⟹   XP_007969392
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11480,905,168 - 80,945,972 (-)NCBI
Vero_WHO_p1.0NW_02366604531,201,565 - 31,245,180 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007969392 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005522.1
Reference Protein Sequences
RefSeq Acc Id: XP_007969392   ⟸   XM_007971201
RefSeq Acc Id: ENSCSAP00000005522   ⟸   ENSCSAT00000007338


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009271 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007338.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro 2pore_dom_K_chnl UniProtKB/TrEMBL
  2pore_dom_K_chnl_TASK UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/TrEMBL
  KCNK3 UniProtKB/TrEMBL
KEGG Report csab:103220628 UniProtKB/TrEMBL
NCBI Gene KCNK3 ENTREZGENE
PANTHER PTHR11003 UniProtKB/TrEMBL
  PTHR11003:SF138 UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/TrEMBL
PIRSF K_channel_subfamily_K_type UniProtKB/TrEMBL
PRINTS 2POREKCHANEL UniProtKB/TrEMBL
  TASK1CHANNEL UniProtKB/TrEMBL
  TASKCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A0D9RA83_CHLSB UniProtKB/TrEMBL