CXCL8 (C-X-C motif chemokine ligand 8) - Rat Genome Database

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Pathways
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Gene: CXCL8 (C-X-C motif chemokine ligand 8) Chlorocebus sabaeus
Analyze
Symbol: CXCL8
Name: C-X-C motif chemokine ligand 8
RGD ID: 18624201
Description: ENCODES a protein that exhibits heparin binding (ortholog); interleukin-8 receptor binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN chemokine (C-X-C motif) ligand 8 signaling pathway; mTOR signaling pathway; syndecan signaling pathway; ASSOCIATED WITH acute asthma (ortholog); Acute Lung Injury (ortholog); acute pyelonephritis (ortholog); FOUND IN extracellular region (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-8; interleukin-8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,202,497 - 22,205,730 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,202,527 - 22,204,068 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084587,605 - 589,481 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute asthma  (ISO)
Acute Lung Injury  (ISO)
acute pyelonephritis  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic hepatitis  (ISO)
allergic disease  (ISO)
Anorexia  (ISO)
autoimmune uveitis  (ISO)
Bacterial Eye Infections  (ISO)
bacterial gastritis  (ISO)
Bacterial Lung Diseases  (ISO)
Barrett's esophagus  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
Breast Neoplasms  (ISO)
brucellosis  (ISO)
bullous pemphigoid  (ISO)
Cachexia  (ISO)
Cardiotoxicity  (ISO)
Chagas Cardiomyopathy  (ISO)
chikungunya  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
Colorectal Neoplasms  (ISO)
common cold  (ISO)
congestive heart failure  (ISO)
COVID-19  (ISO)
cryptococcosis  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Down syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Edema  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Enterovirus Infections  (ISO)
esophagus squamous cell carcinoma  (ISO)
eumycotic mycetoma  (ISO)
Experimental Colitis  (ISO)
extrapulmonary tuberculosis  (ISO)
Fever  (ISO)
gastritis  (ISO)
gastroesophageal reflux disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
head and neck cancer  (ISO)
Helicobacter Infections  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (ISO)
Inflammation  (ISO)
Inflammatory Breast Neoplasms  (ISO)
intermediate coronary syndrome  (ISO)
Intractable Pain  (ISO)
intrahepatic cholestasis  (ISO)
keratitis  (ISO)
Klebsiella pneumonia  (ISO)
leprosy  (ISO)
lichen disease  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Liver Metastasis  (ISO)
lung non-small cell carcinoma  (ISO)
Lyme Neuroborreliosis  (ISO)
malignant mesothelioma  (ISO)
multiple sclerosis  (ISO)
Mycobacterium avium complex disease  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
Neurosyphilis  (ISO)
oral cavity cancer  (ISO)
oral submucous fibrosis  (ISO)
oropharynx cancer  (ISO)
otitis media  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
peptic esophagitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
Postherpetic Neuralgia  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
Salmonella Infections, Animal  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spine Osteoarthritis  (ISO)
squamous cell carcinoma  (ISO)
Staphylococcal Infections  (ISO)
steatotic liver disease  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Thyroid Neoplasms  (ISO)
Tobacco Use Disorder  (ISO)
tongue squamous cell carcinoma  (ISO)
tonsil cancer  (ISO)
Toxoplasma Chorioretinitis  (ISO)
trachoma  (ISO)
Triple Negative Breast Neoplasms  (ISO)
tropical spastic paraparesis  (ISO)
trypanosomiasis  (ISO)
tuberculosis  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
viral encephalitis  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
vulvovaginal candidiasis  (ISO)
Wilson disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7561102   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CXCL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,202,497 - 22,205,730 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,202,527 - 22,204,068 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084587,605 - 589,481 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CXCL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,740,569 - 73,743,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,740,519 - 73,743,716 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,606,286 - 74,609,433 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,825,139 - 74,828,297 (+)NCBINCBI36Build 36hg18NCBI36
Build 34474,971,309 - 74,974,466NCBI
Celera471,966,137 - 71,969,295 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,417,707 - 70,420,917 (+)NCBIHuRef
CHM1_1474,642,243 - 74,645,454 (+)NCBICHM1_1
T2T-CHM13v2.0477,084,334 - 77,087,480 (+)NCBIT2T-CHM13v2.0
Cxcl15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,942,393 - 90,950,926 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,942,393 - 90,950,926 (+)EnsemblGRCm39 Ensembl
GRCm38590,794,534 - 90,803,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,794,534 - 90,803,067 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,223,560 - 91,232,093 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,869,771 - 91,877,088 (+)NCBIMGSCv36mm8
Celera588,946,158 - 88,954,669 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Cxcl8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474241,501 - 250,643 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955474247,326 - 250,355 (+)NCBIChiLan1.0ChiLan1.0
CXCL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,320,800 - 56,323,963 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,509,875 - 56,513,034 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,452,857 - 50,456,015 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,285,026 - 56,288,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,286,708 - 56,288,083 (-)Ensemblpanpan1.1panPan2
CXCL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,435,035 - 62,438,354 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,434,422 - 62,438,354 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,104,414 - 62,107,728 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,245,400 - 63,248,688 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,244,998 - 63,248,244 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11362,855,624 - 62,858,940 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,345,249 - 62,348,566 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,485,538 - 63,488,849 (+)NCBIUU_Cfam_GSD_1.0
LOC101964975
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528513,326,322 - 13,329,490 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,779,471 - 1,781,353 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365981,779,471 - 1,781,353 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,932,643 - 69,935,861 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,932,646 - 69,935,861 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,083,530 - 74,086,749 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Cxcl8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247301,743,916 - 1,747,293 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247301,744,097 - 1,747,206 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 2 10
Low 28 10 14
Below cutoff 6 13

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000002814   ⟹   ENSCSAP00000001109
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl722,202,527 - 22,204,068 (+)Ensembl
RefSeq Acc Id: NM_001292081   ⟹   NP_001279010
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666084587,605 - 589,481 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001279010 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACI28915 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001109.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000001109   ⟸   ENSCSAT00000002814
RefSeq Acc Id: NP_001279010   ⟸   NM_001292081
- Peptide Label: precursor
- UniProtKB: B6E125 (UniProtKB/TrEMBL),   A0A0D9QXM0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004781 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002814.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_CXC UniProtKB/TrEMBL
  Chemokine_CXC_CS UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
KEGG Report csab:103235786 UniProtKB/TrEMBL
NCBI Gene CXCL8 ENTREZGENE
PANTHER INTERLEUKIN-8 UniProtKB/TrEMBL
  SMALL INDUCIBLE CYTOKINE A UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PRINTS INTERLEUKIN8 UniProtKB/TrEMBL
  SMALLCYTKCXC UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CXC UniProtKB/TrEMBL
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/TrEMBL
UniProt A0A0D9QXM0 ENTREZGENE, UniProtKB/TrEMBL
  B6E125 ENTREZGENE, UniProtKB/TrEMBL