IPO5 (importin 5) - Rat Genome Database

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Pathways
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Gene: IPO5 (importin 5) Chlorocebus sabaeus
Analyze
Symbol: IPO5
Name: importin 5
RGD ID: 18596040
Description: ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); nuclear localization sequence binding (inferred); small GTPase binding (inferred); INVOLVED IN cellular response to amino acid stimulus (inferred); cytoplasmic pattern recognition receptor signaling pathway (inferred); NLS-bearing protein import into nucleus (inferred); ASSOCIATED WITH Anal Atresia, Hypospadias, and Penoscrotal Inversion (ortholog); Animal Disease Models (ortholog); holoprosencephaly 5 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); Golgi apparatus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: importin-5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1376,644,113 - 76,690,718 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl376,644,131 - 76,692,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604633,103,550 - 33,150,436 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IPO5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1376,644,113 - 76,690,718 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl376,644,131 - 76,692,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604633,103,550 - 33,150,436 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
IPO5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381397,953,675 - 98,024,296 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1397,953,658 - 98,024,296 (+)EnsemblGRCh38hg38GRCh38
GRCh371398,605,929 - 98,676,550 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361397,403,930 - 97,474,551 (+)NCBINCBI36Build 36hg18NCBI36
Celera1379,453,341 - 79,523,964 (+)NCBICelera
Cytogenetic Map13q32.2NCBI
HuRef1379,203,817 - 79,274,125 (+)NCBIHuRef
CHM1_11398,576,302 - 98,646,937 (+)NCBICHM1_1
T2T-CHM13v2.01397,160,508 - 97,231,138 (+)NCBIT2T-CHM13v2.0
Ipo5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914121,134,271 - 121,185,451 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14121,148,636 - 121,185,411 (+)EnsemblGRCm39 Ensembl
GRCm3814120,896,840 - 120,948,046 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14120,911,224 - 120,947,999 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714121,310,416 - 121,347,268 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614120,046,431 - 120,083,179 (+)NCBIMGSCv36mm8
Celera14119,467,218 - 119,497,933 (+)NCBICelera
Cytogenetic Map14E4- E5NCBI
cM Map1464.81NCBI
Ipo5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815104,397,626 - 104,447,985 (+)NCBIGRCr8
mRatBN7.21597,990,755 - 98,041,074 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1598,005,299 - 98,041,126 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.015106,243,110 - 106,293,326 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15106,257,650 - 106,292,112 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015109,639,020 - 109,689,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415105,944,155 - 106,021,407 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115105,983,354 - 106,037,884 (+)NCBI
Celera1596,799,493 - 96,849,477 (+)NCBICelera
Cytogenetic Map15q24NCBI
Ipo5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540412,416,755 - 12,459,452 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540412,416,755 - 12,480,281 (-)NCBIChiLan1.0ChiLan1.0
IPO5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21499,471,672 - 99,541,033 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11398,140,454 - 98,209,817 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01379,115,320 - 79,185,598 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11398,295,472 - 98,336,707 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1398,294,766 - 98,336,700 (+)Ensemblpanpan1.1panPan2
IPO5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12248,126,053 - 48,182,897 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2248,136,242 - 48,180,495 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2247,906,269 - 47,965,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02248,566,642 - 48,625,469 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2248,566,671 - 48,625,439 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12248,215,943 - 48,274,722 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02248,249,947 - 48,308,738 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02248,285,886 - 48,344,697 (+)NCBIUU_Cfam_GSD_1.0
Ipo5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945183,675,492 - 183,720,213 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647212,229,922 - 12,271,964 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647212,231,970 - 12,271,639 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IPO5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1167,004,109 - 67,060,551 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11167,019,299 - 67,059,375 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21174,138,179 - 74,173,295 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Ipo5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479312,969,459 - 13,004,139 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479312,971,397 - 13,004,126 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 16 60
Low 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007960721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000015614   ⟹   ENSCSAP00000013549
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl376,644,131 - 76,692,146 (+)Ensembl
RefSeq Acc Id: XM_007960721   ⟹   XP_007958912
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1376,644,113 - 76,690,718 (+)NCBI
Vero_WHO_p1.0NW_02366604633,103,550 - 33,150,436 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007958912 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013549
  ENSCSAP00000013549.1
Reference Protein Sequences
RefSeq Acc Id: XP_007958912   ⟸   XM_007960721
- UniProtKB: A0A0D9RY60 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000013549   ⟸   ENSCSAT00000015614


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017519 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015614.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  HEAT UniProtKB/TrEMBL
  Importin-beta_N UniProtKB/TrEMBL
  Importin_beta UniProtKB/TrEMBL
  Importin_rep_4 UniProtKB/TrEMBL
  Importin_rep_5 UniProtKB/TrEMBL
  Importin_rep_6 UniProtKB/TrEMBL
  TOG UniProtKB/TrEMBL
KEGG Report csab:103214694 UniProtKB/TrEMBL
NCBI Gene IPO5 ENTREZGENE
PANTHER IMPORTIN-5 UniProtKB/TrEMBL
  PTHR10527 UniProtKB/TrEMBL
Pfam HEAT UniProtKB/TrEMBL
  HEAT_EZ UniProtKB/TrEMBL
  Importin_rep_4 UniProtKB/TrEMBL
  Importin_rep_5 UniProtKB/TrEMBL
  Importin_rep_6 UniProtKB/TrEMBL
PROSITE IMPORTIN_B_NT UniProtKB/TrEMBL
SMART TOG UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A0D9RY60 ENTREZGENE, UniProtKB/TrEMBL