IRX1 (iroquois homeobox 1) - Rat Genome Database

Name: IRX1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: IRX1 (iroquois homeobox 1) Chlorocebus sabaeus

Analyze

Symbol:

IRX1

Name:

iroquois homeobox 1

RGD ID:

18585771

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN positive regulation of gene expression (ortholog); response to organic cyclic compound (ortholog); ASSOCIATED WITH congenital heart disease (ortholog); congestive heart failure (ortholog); lung disease (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

iroquois-class homeodomain protein IRX-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IRX1 (iroquois homeobox 1)	NCBI	Ortholog
Mus musculus (house mouse):	Irx1 (Iroquois homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Irx1 (iroquois homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Irx1 (iroquois homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IRX1 (iroquois homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IRX1 (iroquois homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Irx1 (iroquois homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IRX1 (iroquois homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Irx1 (iroquois homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	3,365,880 - 3,371,520 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	3,366,384 - 3,371,670 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666064	25,439,633 - 25,445,218 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital heart disease (ISO)

congestive heart failure (ISO)

lung disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell development (IEA)

metanephros development (IEA)

negative regulation of transcription by RNA polymerase II (IEA)

neuron differentiation (IEA)

positive regulation of gene expression (ISO)

proximal/distal pattern formation involved in metanephric nephron development (IEA)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IEA)

response to organic cyclic compound (ISO)

specification of loop of Henle identity (IEA)

Cellular Component

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

IRX1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	3,365,880 - 3,371,520 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	3,366,384 - 3,371,670 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666064	25,439,633 - 25,445,218 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

IRX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	3,595,832 - 3,601,403 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	3,595,832 - 3,601,403 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	3,595,946 - 3,601,517 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	3,649,168 - 3,654,517 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	3,649,167 - 3,654,517	NCBI
Celera	5	3,626,588 - 3,631,937 (+)	NCBI		Celera
Cytogenetic Map	5	p15.33	NCBI
HuRef	5	3,569,035 - 3,575,436 (+)	NCBI		HuRef
CHM1_1	5	3,596,269 - 3,601,617 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	3,514,530 - 3,520,100 (+)	NCBI		T2T-CHM13v2.0

Irx1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	72,106,351 - 72,111,842 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	72,106,040 - 72,111,842 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	71,958,232 - 71,963,723 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	71,957,921 - 71,963,723 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	72,095,680 - 72,101,171 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	72,424,607 - 72,429,479 (-)	NCBI		MGSCv36	mm8
Celera	13	74,285,058 - 74,290,917 (-)	NCBI		Celera
Cytogenetic Map	13	C1	NCBI
cM Map	13	38.43	NCBI

Irx1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	33,123,122 - 33,128,951 (+)	NCBI		GRCr8
mRatBN7.2	1	31,294,615 - 31,300,444 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	31,294,615 - 31,300,444 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	31,103,832 - 31,109,675 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	37,102,756 - 37,108,597 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	31,302,605 - 31,308,446 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	33,910,912 - 33,916,741 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	33,910,912 - 33,916,741 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	35,319,895 - 35,325,724 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	1,390,894 - 1,396,724 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	1,391,104 - 1,396,424 (+)	NCBI
Celera	1	29,929,767 - 29,935,596 (+)	NCBI		Celera
Cytogenetic Map	1	p11	NCBI

Irx1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955504	2,072,540 - 2,099,781 (+)	NCBI	ChiLan1.0	ChiLan1.0

IRX1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	3,848,593 - 3,854,175 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	2,002,201 - 2,007,783 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	3,922,252 - 3,927,836 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	3,610,229 - 3,615,279 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	3,610,225 - 3,615,279 (+)	Ensembl	panpan1.1		panPan2

IRX1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	9,537,231 - 9,544,029 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	9,538,479 - 9,544,029 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	14,053,493 - 14,058,919 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	9,440,824 - 9,446,274 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	9,440,808 - 9,446,627 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	9,488,276 - 9,493,698 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	9,467,500 - 9,472,927 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	9,682,784 - 9,688,233 (-)	NCBI		UU_Cfam_GSD_1.0

Irx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	242,538,955 - 242,544,555 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936634	3,130,167 - 3,135,537 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936634	3,130,197 - 3,135,273 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IRX1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	77,695,071 - 77,701,236 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	77,695,704 - 77,701,089 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Irx1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624751	2,010,004 - 2,014,721 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624751	2,005,849 - 2,014,775 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low	18	11	37
Below cutoff	3	6	23

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007961160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000015441 ⟹ ENSCSAP00000013383

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	4	3,366,384 - 3,371,670 (+)	Ensembl

RefSeq Acc Id:

XM_007961160 ⟹ XP_007959351

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	4	3,365,880 - 3,371,520 (+)	NCBI
Vero_WHO_p1.0	NW_023666064	25,439,633 - 25,445,218 (-)	NCBI

Sequence:

show sequence

GCAAGGGGCGGGGCCTGCGCTCAAGGGGATGCCAATCAAAGCATCAACTTCAAATTGTGTCTGA
AAGCCCCGCCGCTGAGCGGAGGGCGGCCGCCGCAGTCGGCGCGCGATCGCGGATCCGGGCGCAG
CCGGGAGCCGGGCGCCTGGGAGCACCGGGCCGAGGAACCGCAACCGGCCCCCATCTCTCGGCCC
GCCCGAGCGCGCCCGGCTGGCCGCCAACTCCTCCCTAGACCCCTCGCGGCGCCCCCTGCAATCC
CCCTCCGGCCGGCCTCCGTCTCCCTCTCCGCGCCTTTAATATTCGCCCGCTGCGGCGGTCGCCG
AGTCCGCGGACATGTCCTTCCCGCAGCTGGGCTACCCGCAGTACCTGAGCGCCGCGGGGCCCGG
CGCCTACGGTGGCGAGCGCCCGGGAGTGCTAGCCGCTGCCGCTGCTGCTGCGGCCGCCGCTTCG
TCGGGTCGACCCGGGGCCGCGGAGCTGGGCGGCGGGGCGGGCGCGGCTGCGGTCACCTCGGTGT
TGGGCATGTACGCGGCGGCGGGGCCGTACGCGGGCGCGCCCAACTACAGCGCCTTCCTGCCCTA
CGCCGCGGATCTCAGCCTCTTCTCGCAGATGGGCTCGCAGTATGAACTCAAGGACAACCCTGGG
GTGCACCCCGCCACCTTCGCAGCCCACACGGCGCCGGCTTATTACCCCTACGGCCAGTTCCAAT
ACGGGGACCCCGGGCGGCCCAAGAACGCCACCCGCGAGAGCACCAGCACGCTCAAGGCCTGGCT
CAACGAGCACCGCAAGAACCCCTACCCCACCAAGGGCGAGAAGATCATGCTGGCCATCATCACC
AAGATGACCCTCACGCAGGTCTCCACCTGGTTCGCCAACGCGCGCCGGCGCCTCAAGAAGGAGA
ACAAGGTGACATGGGGAGCGCGCAGCAAGGACCAGGAAGATGGAGCTCTCTTCGGCAGCGACAC
CGAGGGCGACCCGGAGAAGGCCGAGGACGACGAGGAGATCGACCTGGAAAGTATCGACATCGAC
AAGATCGACGAGCACGATGGAGACCAGAGCAACGAGGACGACGAGGACAAGGCCGAGGCTCCTC
ACGCACCCGCAGCCCCTTCTGCTCTTGCTCGGGACCAAGGCTCGCCGCTGGCAGTAGCCGACGT
TCTCAAGCCCCAGGACTCGCCCTTGGGCCTGGCCAAGGAGGCCCCAGAGCCCGGCAGCACGCGC
CTGCTGAGCCCCGGCGCTGCAGCGGGCGGCCTGCAGGGTGCGCCGCACGGCAAGCCCAAGATCT
GGTCGCTGGCCGAGACAGCCACGAGCCCCGATGGCGCGCCCAAGGCTTCCCCGCCGCCGCCTGC
GGGCCACCCGGGCGCGCACGGGCCCTCCGCCGGCGCACCGCTGCAACACCCCGCCTTCCTGCCC
AGCCACGGACTGTACACCTGCCACATCGGCAAGTTCTCCAACTGGACCAACAGCGCATTCCTCG
CACAGGGTTCGCTGCTCAACATGCGCTCCTTCCTGGGCGTTGGCGCCCCCCACGCCGCGCCCCA
TGGCCCTCACCTTCCTGCACCTCCACCACCTCAGCCGCCGGTCGCCATTGCCCCGGGGACGCTC
ACCGGAGACAAGGCCTCGACCCGCAGCAGCCCCACGCTCCCAGAGAGAGACCTCGTCCCCAGGC
CAGATTCGCCGGCACAGCAGTTAAAGTCGCCTTTCCAGCCGGTACGCGACAACTCTCTGGCCCC
CCAGGAGGGAACGCCGCGGATCCTAGCAGCCCTCCCGTCCGCCTGATTAAGGGTCTTCTTTTAC
TTTTGCGGGGAGGGGGGAGTGGGGAGGAGTTGGGGAGGGAGGGAATGTGGGAGGAATTAAGACA
AATATTTCAGACTGGTGTAAAGGACAAATATGACAACGACGTCAAGGACTCCCATCCATCGCTT
TCTGCAGACAGGGGCTTGTTCGGTCCCGAGCTCGCGTCCAGGCGGCCAGGCCTCTGCAGGCGGC
TCCGGCGGCTGCGATTATCGGGTTCGGTAAATGCCCCCACATGCTTGTGTCTCTTTCCCCCCTT
TTCTGTATATAGAGTGATTTCAGATTGTAAATAGCGCGTCAGCGAACTTGTCTAAATCATATAT
TTTTGTCTAATAAACTAAATGAAATGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007959351	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000013383.1

RefSeq Acc Id:	XP_007959351 ⟸ XM_007961160
- UniProtKB:	A0A0D9RXP4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000013383 ⟸ ENSCSAT00000015441

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000017349	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000015441.1	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Homeobox_KN_domain	UniProtKB/TrEMBL
	Iroquois_homeo	UniProtKB/TrEMBL
NCBI Gene	IRX1	ENTREZGENE
PANTHER	IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX	UniProtKB/TrEMBL
	IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-1	UniProtKB/TrEMBL
Pfam	Homeobox_KN	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
	IRO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	A0A0D9RXP4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - CTD