XRCC3 (X-ray repair cross complementing 3) - Rat Genome Database

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Pathways
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Gene: XRCC3 (X-ray repair cross complementing 3) Chlorocebus sabaeus
Analyze
Symbol: XRCC3
Name: X-ray repair cross complementing 3
RGD ID: 18558850
Description: ENCODES a protein that exhibits crossover junction DNA endonuclease activity (ortholog); four-way junction DNA binding (ortholog); INVOLVED IN DNA metabolic process (inferred); DNA repair (inferred); double-strand break repair via homologous recombination (inferred); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH basal cell carcinoma (ortholog); brain glioma (ortholog); breast cancer (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA repair protein XRCC3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12481,627,911 - 81,641,598 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2481,630,099 - 81,641,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605368,942,543 - 68,955,259 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
XRCC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12481,627,911 - 81,641,598 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2481,630,099 - 81,641,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605368,942,543 - 68,955,259 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
XRCC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814103,697,617 - 103,715,451 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14103,697,609 - 103,715,504 (-)EnsemblGRCh38hg38GRCh38
GRCh3714104,163,954 - 104,181,788 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614103,233,707 - 103,251,576 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414103,233,707 - 103,251,549NCBI
Celera1484,218,198 - 84,236,079 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1484,342,246 - 84,360,133 (-)NCBIHuRef
CHM1_114104,102,095 - 104,119,977 (-)NCBICHM1_1
T2T-CHM13v2.01497,933,664 - 97,951,508 (-)NCBIT2T-CHM13v2.0
Xrcc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,769,626 - 111,780,326 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12111,769,626 - 111,780,307 (-)EnsemblGRCm39 Ensembl
GRCm3812111,803,192 - 111,813,893 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,803,192 - 111,813,873 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712113,041,404 - 113,052,052 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612112,251,001 - 112,261,649 (-)NCBIMGSCv36mm8
MGSCv3612106,079,489 - 106,090,338 (-)NCBIMGSCv36mm8
Celera12113,007,859 - 113,018,415 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.14NCBI
Xrcc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,684,558 - 136,694,822 (-)NCBIGRCr8
mRatBN7.26130,863,405 - 130,873,765 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,863,959 - 130,872,444 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.06136,366,917 - 136,380,751 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,371,555 - 136,379,348 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06145,372,463 - 145,388,673 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,594,276 - 136,602,069 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6128,413,783 - 128,427,617 (-)NCBICelera
Cytogenetic Map6q32NCBI
Xrcc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555382,501,607 - 2,509,778 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555382,499,297 - 2,511,898 (-)NCBIChiLan1.0ChiLan1.0
XRCC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215104,855,879 - 104,870,378 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114104,072,380 - 104,091,265 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01484,323,644 - 84,341,763 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114104,131,908 - 104,146,133 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14104,131,903 - 104,149,037 (-)Ensemblpanpan1.1panPan2
XRCC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1871,441,732 - 71,452,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl871,442,429 - 71,449,408 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha870,954,852 - 70,966,020 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0871,720,493 - 71,731,659 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl871,720,507 - 71,728,101 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1871,409,125 - 71,420,318 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0871,449,552 - 71,460,747 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0871,848,235 - 71,859,401 (-)NCBIUU_Cfam_GSD_1.0
Xrcc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086402,633,405 - 2,645,985 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366211,462,428 - 1,473,868 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366211,462,441 - 1,474,937 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XRCC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27130,828,033 - 130,841,152 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Xrcc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247341,217,549 - 1,223,280 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247341,216,641 - 1,223,860 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 31 30
Low 5 20 30
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000007962   ⟹   ENSCSAP00000006122
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2481,630,099 - 81,641,218 (-)Ensembl
RefSeq Acc Id: XM_007987955   ⟹   XP_007986146
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12481,627,911 - 81,641,359 (-)NCBI
Vero_WHO_p1.0NW_02366605368,942,543 - 68,955,259 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007986146 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006122.1
Reference Protein Sequences
RefSeq Acc Id: XP_007986146   ⟸   XM_007987955
- UniProtKB: A0A0D9RBY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000006122   ⟸   ENSCSAT00000007962


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009906 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007962.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro DNA_recomb/repair_Rad51_C UniProtKB/TrEMBL
  DNA_recomb/repair_RecA-like UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RecA_ATP-bd UniProtKB/TrEMBL
  XRCC3-like_C UniProtKB/TrEMBL
KEGG Report csab:103229765 UniProtKB/TrEMBL
NCBI Gene XRCC3 ENTREZGENE
PANTHER DNA REPAIR PROTEIN XRCC3 UniProtKB/TrEMBL
  DNA REPAIR PROTEIN XRCC3 UniProtKB/TrEMBL
Pfam Rad51 UniProtKB/TrEMBL
PIRSF Rad51 UniProtKB/TrEMBL
PROSITE RECA_2 UniProtKB/TrEMBL
Superfamily-SCOP C-terminal domain of RNA polymerase alpha subunit UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9RBY3 ENTREZGENE, UniProtKB/TrEMBL