NSUN5 (NOP2/Sun RNA methyltransferase 5)

Gene: NSUN5 (NOP2/Sun RNA methyltransferase 5) Chlorocebus sabaeus

Analyze

Symbol:

NSUN5

Name:

NOP2/Sun RNA methyltransferase 5

RGD ID:

18502189

Description:

ENCODES a protein that exhibits methyltransferase activity (inferred); RNA binding (inferred); RNA methyltransferase activity (inferred); INVOLVED IN cerebral cortex development (inferred); cognition (inferred); corpus callosum development (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); intestinal volvulus (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

28S rRNA (cytosine-C(5))-methyltransferase; NOP2/Sun RNA methyltransferase family member 5; putative methyltransferase NSUN5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	9,737,722 - 9,743,372 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	9,737,777 - 9,743,189 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	6,719,347 - 6,724,999 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

intestinal volvulus (ISO)

Neurodevelopmental Disorders (ISO)

pleomorphic xanthoastrocytoma (ISO)

Volvulus Of Midgut (ISO)

Williams-Beuren syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cerebral cortex development (IEA)

cognition (IEA)

corpus callosum development (IEA)

methylation (IEA)

oligodendrocyte development (IEA)

positive regulation of translation (IEA)

regulation of myelination (IEA)

RNA methylation (IEA)

rRNA base methylation (IEA)

Cellular Component

nucleolus (IEA)

nucleoplasm (IEA)

Molecular Function

methyltransferase activity (IEA)

RNA binding (IEA)

RNA methyltransferase activity (IEA)

rRNA (cytosine-C5-)-methyltransferase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

NSUN5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	9,737,722 - 9,743,372 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	9,737,777 - 9,743,189 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	6,719,347 - 6,724,999 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

NSUN5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	73,302,516 - 73,308,826 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	73,302,516 - 73,308,826 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	72,716,513 - 72,722,823 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	72,355,162 - 72,360,759 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	68,194,805 - 68,201,154 (-)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	68,598,255 - 68,604,606 (-)	NCBI		HuRef
CHM1_1	7	72,862,538 - 72,868,889 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	74,502,674 - 74,508,983 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	72,049,585 - 72,055,936 (-)	NCBI

Nsun5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	135,398,784 - 135,405,661 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	135,398,807 - 135,405,659 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	135,369,930 - 135,376,805 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	135,369,953 - 135,376,805 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	135,845,823 - 135,852,667 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	135,654,587 - 135,660,770 (+)	NCBI		MGSCv36	mm8
Celera	5	132,381,655 - 132,388,499 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	75.16	NCBI

Nsun5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	26,930,204 - 26,935,887 (-)	NCBI		GRCr8
mRatBN7.2	12	21,293,637 - 21,299,319 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	21,293,645 - 21,299,272 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	22,436,101 - 22,441,065 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	23,048,433 - 23,053,397 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	22,114,913 - 22,119,877 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	24,341,940 - 24,346,900 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	24,341,928 - 24,346,918 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	26,339,243 - 26,344,203 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	22,448,736 - 22,453,696 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	22,439,243 - 22,444,280 (-)	NCBI
Celera	12	23,056,841 - 23,061,799 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

Nsun5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	14,331,924 - 14,335,973 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	14,331,890 - 14,336,650 (+)	NCBI	ChiLan1.0	ChiLan1.0

NSUN5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	91,592,636 - 91,602,346 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	139,857,274 - 139,862,769 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	7	80,454,524 - 80,461,353 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	80,455,353 - 80,461,316 (-)	Ensembl	panpan1.1		panPan2

NSUN5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	6,887,941 - 6,899,515 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	6,888,005 - 6,899,517 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	8,585,100 - 8,597,403 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	6,708,346 - 6,720,875 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	6,708,400 - 6,720,883 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	6,678,489 - 6,690,838 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	6,641,234 - 6,653,754 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	6,804,538 - 6,816,853 (+)	NCBI		UU_Cfam_GSD_1.0

Nsun5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	131,411,968 - 131,419,043 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	2,617,532 - 2,621,272 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	2,618,097 - 2,624,599 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NSUN5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	10,632,677 - 10,642,061 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	10,632,670 - 10,642,063 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	10,337,653 - 10,346,350 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Nsun5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	14,413,489 - 14,419,340 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	14,413,451 - 14,418,255 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	7	56
Low		13	4
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008018359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008018360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037990491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000016257 ⟹ ENSCSAP00000014177

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	28	9,737,777 - 9,743,189 (+)	Ensembl

RefSeq Acc Id:

XM_008018360 ⟹ XP_008016551

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	28	9,737,722 - 9,743,372 (+)	NCBI
Vero_WHO_p1.0	NW_023666070	6,719,347 - 6,724,999 (-)	NCBI

Sequence:

show sequence

TTGACCCCGGAAGTTCGGGCGTGCGCAGAGCCGGGAGCGCTTTGCGACAGAGCCGTAAAGGCGC
GCGGGAACATGGGGCTGTACGCTGTCGCGGCAGACGTGCTGGCAGGCGTGGAGAACCGCCAGGG
CTCCATCAAGGGGCTGGTGTACTCCAGCAACTTCCAGAACGTGAAGCAGCTGTACGCGCTGGTG
TGCGAAACGCAGCGCTACTCCGCCGTGCTGGATGCCGTAATCGCCAGCGCCGGCCTCCTCCGTG
CGGAGAAGAAGCTGCGGCCGCACCTGGCCAAGGTGCTAGTGTATGAGTTGTTGTTGGGAAAGGG
CTTTCGAGGTGGTGGGGGCCGATGGAAGGCTCTATTGAGCCGGCACCAGGCGAGGCTCAAGGCT
GAGTTGGCTCGGCTTAAGGTTCATCGGGGTGTGAGCCGGAATGAGGACCTGTTGGAAGTGGGAT
CCAGGCCTGGTCCAGTCTCCCAGCTGCCTCGATTTGTGCGTGTGAATACTCTCAAGACCTGCTC
CAATGATGTAGTTGATTATTTCAAGAGGCAAGGTTTCTCCTATCAGGGTCGGGCTTCCAGCCTC
GACGACTTACGAGCCCTCAAGGGGAAGCATTTTCTCCTGGACCCCTTGATGGCGGAGCTGCTGG
TATTTCCCGCCCAGACAGATCTGCATGAACACCCACTGTACCGGGCCGGACACCTCATTCTGCA
GGACAGGGCAAGCTGTCTCCCAGCCATGTTGCTGAACCCTCCGCCAGGTTCCCATGTCATTGAT
GCCTGTGCCGCCCCAGGAAATAAGACCAGTCACTTGGCTGCTCTTCTGAAGAACCAAGGGAAGA
TCTTTGCCTTTGACTTGGATGCCAAGCGGCTGGCATCAATGGCCACGCTGCTGGCCCGGGCTGG
CATCTCCTGCTGTGAGCTGGCTGAGGAGGACTTCCTGGCGGTCTCCCCCTCAGACCCACGCTAC
CGTGAGGTCCACTACATCCTGCTGGATCCTTCCTGCAGTGGCTCAGGTATGCCGAGCAGACAGC
TGGAGGAGCCCGGGGCAGGCACACCTAGCCCGGCGCGTCTGCATGCCCTGGCGGGGTTCCAGCA
GCGAGCCCTGTGCCACGCGCTCACTTTCCCTTCCCTGAAGCGGCTCGTCTACTCTACGTGCTCC
CTCTGCCAGGAGGAGAATGAAGACGTGGTGCGAGATGCGCTGCAGCAGAACCCTGGTGCCTTCA
GGCTAGCTCCTGCCCTGCCTGCCTGGCCCCACCGAGGCCTGAGCACGTTCCCGGATGCCGAGCA
CTGCCTCCGGGCCTCCCCTGAGACCACGCTCAGCGGTGGCTTCTTCGTTGCCGTAATTGAACGG
GTCGAGGCGCCGAGTTCCGCCTCACAGGCTAAAGCATCAGCACCAGAATGCACACCCAGCCCAG
CCCCAAAGAGAAAGAAGAGACAGCAAAAAGCCGGAGCCGGTGCTTGCACGCCGCCTTGCACATA
GCAGAGGCTTCGGGCTGACTCCTTCCTGGTAGGAAAGGAAGACGCCTGTCCTCTCCGTGGAGGA
CCCTGGGCCCTCACCGCATGCAGTAATTTGGGTTTTGAAAGGTTATTGGGTCCTTTCCTTGGGC
TGTGTTCTTGCTGGTGAGAAAACTGCCTGCAGAAATAAAATGCAGAACGTACTCTA

hide sequence

RefSeq Acc Id:

XM_037990491 ⟹ XP_037846419

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666070	6,719,347 - 6,724,999 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_008016551	(Get FASTA)	NCBI Sequence Viewer
	XP_037846419	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000014177
	ENSCSAP00000014177.1

RefSeq Acc Id:	XP_008016551 ⟸ XM_008018360
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RZY8 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000014177 ⟸ ENSCSAT00000016257

RefSeq Acc Id:	XP_037846419 ⟸ XM_037990491
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000018161	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000016257.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
InterPro	MeTrfase_RsmB-F_NOP2_cat	UniProtKB/TrEMBL
	MeTrfase_RsmB/NOP2	UniProtKB/TrEMBL
	NSUN5_7_fdxn-like	UniProtKB/TrEMBL
	NSUN5_RCM1_N	UniProtKB/TrEMBL
	RCMT	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
NCBI Gene	NSUN5	ENTREZGENE
PANTHER	28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE	UniProtKB/TrEMBL
	PTHR22807	UniProtKB/TrEMBL
Pfam	Methyltr_RsmB-F	UniProtKB/TrEMBL
	NSUN5_fdxn-like	UniProtKB/TrEMBL
	NSUN5_N	UniProtKB/TrEMBL
PRINTS	RCMTFAMILY	UniProtKB/TrEMBL
PROSITE	SAM_MT_RSMB_NOP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A0A0D9RZY8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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