EME1 (essential meiotic structure-specific endonuclease 1) - Rat Genome Database

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Gene: EME1 (essential meiotic structure-specific endonuclease 1) Chlorocebus sabaeus
Analyze
Symbol: EME1
Name: essential meiotic structure-specific endonuclease 1
RGD ID: 18497931
Description: ENCODES a protein that exhibits crossover junction DNA endonuclease activity (inferred); DNA binding (inferred); hydrolase activity (inferred); INVOLVED IN response to intra-S DNA damage checkpoint signaling (ortholog); ASSOCIATED WITH osteogenesis imperfecta type 1 (ortholog); trichodontoosseous syndrome (ortholog); FOUND IN endodeoxyribonuclease complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: crossover junction endonuclease EME1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,949,059 - 42,957,323 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1642,949,570 - 42,955,312 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,664,506 - 13,673,049 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EME1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,949,059 - 42,957,323 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1642,949,570 - 42,955,312 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,664,506 - 13,673,049 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
EME1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,373,229 - 50,381,483 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,373,220 - 50,381,483 (+)EnsemblGRCh38hg38GRCh38
GRCh371748,450,590 - 48,458,844 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,805,589 - 45,813,817 (+)NCBINCBI36Build 36hg18NCBI36
Build 341745,805,588 - 45,813,817NCBI
Celera1744,911,870 - 44,920,109 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,818,443 - 43,826,682 (+)NCBIHuRef
CHM1_11748,514,429 - 48,522,668 (+)NCBICHM1_1
T2T-CHM13v2.01751,240,214 - 51,248,468 (+)NCBIT2T-CHM13v2.0
Eme1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,535,798 - 94,544,611 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,535,822 - 94,544,790 (-)EnsemblGRCm39 Ensembl
GRCm381194,644,972 - 94,653,836 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,644,996 - 94,653,964 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,506,316 - 94,515,068 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,461,092 - 94,469,844 (-)NCBIMGSCv36mm8
Celera11104,262,545 - 104,271,339 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.9NCBI
Eme1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,083,585 - 80,092,450 (-)NCBIGRCr8
mRatBN7.21079,586,718 - 79,595,515 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,586,729 - 79,595,435 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1084,191,828 - 84,197,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,689,904 - 83,695,898 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,205,340 - 79,211,374 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,366,820 - 82,375,510 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,367,084 - 82,374,171 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,185,158 - 82,194,105 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,279,086 - 83,285,091 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,293,455 - 83,299,461 (-)NCBI
Celera1078,374,984 - 78,380,578 (-)NCBICelera
Cytogenetic Map10q26NCBI
Eme1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,329,601 - 11,334,372 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,328,759 - 11,336,099 (-)NCBIChiLan1.0ChiLan1.0
EME1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,564,665 - 66,573,300 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,372,113 - 71,380,389 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01744,467,537 - 44,475,883 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11749,341,791 - 49,349,959 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,341,791 - 49,349,959 (+)Ensemblpanpan1.1panPan2
EME1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,342,419 - 26,350,561 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,344,438 - 26,349,997 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,735,404 - 25,743,563 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0927,136,828 - 27,144,964 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl927,138,844 - 27,144,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,904,602 - 25,912,748 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,163,280 - 26,171,437 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,293,303 - 26,301,463 (+)NCBIUU_Cfam_GSD_1.0
Eme1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,758,874 - 25,766,971 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,308,393 - 11,314,785 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,307,739 - 11,316,203 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EME1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,670,176 - 26,680,601 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,670,126 - 26,680,097 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,603,468 - 26,611,786 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Eme1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,311,065 - 6,316,237 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247956,309,186 - 6,316,707 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 9
Low 36 20 51
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000003431   ⟹   ENSCSAP00000001707
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1642,949,570 - 42,955,312 (-)Ensembl
RefSeq Acc Id: XM_008011513   ⟹   XP_008009704
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11642,949,059 - 42,957,323 (-)NCBI
Vero_WHO_p1.0NW_02366607713,664,506 - 13,673,049 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008011514   ⟹   XP_008009705
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11642,949,059 - 42,957,323 (-)NCBI
Vero_WHO_p1.0NW_02366607713,664,506 - 13,673,049 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008009704 (Get FASTA)   NCBI Sequence Viewer  
  XP_008009705 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001707.1
Reference Protein Sequences
RefSeq Acc Id: XP_008009704   ⟸   XM_008011513
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QZB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008009705   ⟸   XM_008011514
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QZB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000001707   ⟸   ENSCSAT00000003431


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005404 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003431.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.670 UniProtKB/TrEMBL
  3.40.1620.30 UniProtKB/TrEMBL
  4.10.800.30 UniProtKB/TrEMBL
InterPro EME1/EME2_C UniProtKB/TrEMBL
  Eme1_nucdom_sub2 UniProtKB/TrEMBL
  ERCC4_domain UniProtKB/TrEMBL
  ERCC4_Mus81-Eme1_nucdom_sub1 UniProtKB/TrEMBL
  Mms4/EME1/EME2 UniProtKB/TrEMBL
  XPF_nuclease_EME1_vertebrates UniProtKB/TrEMBL
KEGG Report csab:103242936 UniProtKB/TrEMBL
NCBI Gene EME1 ENTREZGENE
PANTHER CROSSOVER JUNCTION ENDONUCLEASE EME1 UniProtKB/TrEMBL
  PTHR21077 UniProtKB/TrEMBL
Pfam EME1-MUS81_C UniProtKB/TrEMBL
  ERCC4 UniProtKB/TrEMBL
SMART ERCC4 UniProtKB/TrEMBL
UniProt A0A0D9QZB8 ENTREZGENE, UniProtKB/TrEMBL