MLST8 (MTOR associated protein, LST8 homolog) - Rat Genome Database

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Gene: MLST8 (MTOR associated protein, LST8 homolog) Chlorocebus sabaeus
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Symbol: MLST8
Name: MTOR associated protein, LST8 homolog
RGD ID: 18482888
Description: ENCODES a protein that exhibits protein serine/threonine kinase activator activity (ortholog); INVOLVED IN positive regulation of actin filament polymerization (ortholog); positive regulation of peptidyl-tyrosine phosphorylation (ortholog); positive regulation of TOR signaling (ortholog); PARTICIPATES IN mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH autosomal dominant polycystic kidney disease (ortholog); developmental and epileptic encephalopathy 1 (ortholog); endometrial carcinoma (ortholog); FOUND IN TORC1 complex (ortholog); TORC2 complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: target of rapamycin complex subunit LST8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,101,044 - 2,105,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,101,891 - 2,105,739 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,956,518 - 28,960,758 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
lysosomal membrane  (IEA)
TORC1 complex  (IEA,ISO)
TORC2 complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MLST8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,101,044 - 2,105,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,101,891 - 2,105,739 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,956,518 - 28,960,758 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MLST8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,205,454 - 2,209,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,204,248 - 2,209,453 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,255,455 - 2,259,454 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,195,451 - 2,199,419 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,195,495 - 2,199,414NCBI
Celera162,469,868 - 2,473,835 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,181,357 - 2,185,596 (+)NCBIHuRef
CHM1_1162,255,106 - 2,259,344 (+)NCBICHM1_1
T2T-CHM13v2.0162,227,913 - 2,231,910 (+)NCBIT2T-CHM13v2.0
Mlst8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,692,524 - 24,698,722 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,692,525 - 24,698,052 (-)EnsemblGRCm39 Ensembl
GRCm381724,473,550 - 24,479,114 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,473,551 - 24,479,078 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,610,496 - 24,616,023 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,201,153 - 24,206,678 (-)NCBIMGSCv36mm8
Celera1724,989,327 - 24,994,854 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.39NCBI
Mlst8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,002,927 - 14,008,678 (-)NCBIGRCr8
mRatBN7.21013,498,377 - 13,504,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,498,388 - 13,504,128 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,244,945 - 18,250,695 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,733,790 - 17,739,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,232,975 - 13,238,725 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,839,250 - 13,845,001 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,839,250 - 13,845,001 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,656,236 - 13,661,987 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,725,510 - 13,731,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,725,520 - 13,731,261 (-)NCBI
Celera1013,178,857 - 13,184,608 (-)NCBICelera
Cytogenetic Map10q12NCBI
Mlst8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,056,363 - 15,060,300 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,056,363 - 15,060,300 (-)NCBIChiLan1.0ChiLan1.0
MLST8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,707,554 - 2,712,302 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,488,454 - 6,493,202 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,063,534 - 1,067,706 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,306,451 - 2,310,828 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,306,451 - 2,310,828 (+)Ensemblpanpan1.1panPan2
MLST8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,759,713 - 38,765,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,762,103 - 38,765,488 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,999,004 - 40,004,847 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,068,199 - 39,074,042 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,068,201 - 39,073,985 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,753,209 - 38,759,052 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,725,535 - 38,731,378 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,204,256 - 39,210,099 (-)NCBIUU_Cfam_GSD_1.0
Mlst8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,859,878 - 104,872,523 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,834,701 - 1,842,719 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,839,135 - 1,849,307 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLST8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,778,754 - 39,788,285 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,778,746 - 39,786,206 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,394,842 - 42,398,552 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Mlst8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462491347,962 - 55,048 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462491350,622 - 54,643 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 46
Low 20 14
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000008967   ⟹   ENSCSAP00000007097
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl52,101,891 - 2,105,739 (+)Ensembl
RefSeq Acc Id: XM_007982446   ⟹   XP_007980637
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.152,101,044 - 2,105,272 (+)NCBI
Vero_WHO_p1.0NW_02366606828,956,518 - 28,960,727 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007982456   ⟹   XP_007980647
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.152,101,409 - 2,105,272 (+)NCBI
Vero_WHO_p1.0NW_02366606828,956,518 - 28,960,330 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007982464   ⟹   XP_007980655
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.152,101,044 - 2,105,272 (+)NCBI
Vero_WHO_p1.0NW_02366606828,956,518 - 28,960,758 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007982472   ⟹   XP_007980663
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.152,101,409 - 2,105,105 (+)NCBI
Vero_WHO_p1.0NW_02366606828,956,518 - 28,960,016 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007980637 (Get FASTA)   NCBI Sequence Viewer  
  XP_007980647 (Get FASTA)   NCBI Sequence Viewer  
  XP_007980655 (Get FASTA)   NCBI Sequence Viewer  
  XP_007980663 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000007097
  ENSCSAP00000007097.1
RefSeq Acc Id: XP_007980637   ⟸   XM_007982446
- UniProtKB: A0A0D9REQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007980655   ⟸   XM_007982464
- UniProtKB: A0A0D9REQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007980647   ⟸   XM_007982456
- UniProtKB: A0A0D9REQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007980663   ⟸   XM_007982472
- UniProtKB: A0A0D9REQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000007097   ⟸   ENSCSAT00000008967


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010878 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008967.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  MLST8 UniProtKB/TrEMBL
  Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
KEGG Report csab:103226678 UniProtKB/TrEMBL
NCBI Gene MLST8 ENTREZGENE
PANTHER PTHR19842 UniProtKB/TrEMBL
  TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50998 UniProtKB/TrEMBL
UniProt A0A0D9REQ8 ENTREZGENE, UniProtKB/TrEMBL