ORC1 (origin recognition complex subunit 1) - Rat Genome Database

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Gene: ORC1 (origin recognition complex subunit 1) Chlorocebus sabaeus
Analyze
Symbol: ORC1
Name: origin recognition complex subunit 1
RGD ID: 18468177
Description: ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN positive regulation of G0 to G1 transition (ortholog); positive regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH COVID-19 (ortholog); Dwarfism (ortholog); Fetal Growth Retardation (ortholog); FOUND IN chromosome, telomeric region (ortholog); nuclear origin of replication recognition complex (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12080,540,331 - 80,571,989 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2080,542,532 - 80,572,237 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603336,698,289 - 36,730,187 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ORC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12080,540,331 - 80,571,989 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2080,542,532 - 80,572,237 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603336,698,289 - 36,730,187 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ORC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38152,372,829 - 52,409,503 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl152,372,829 - 52,404,423 (-)EnsemblGRCh38hg38GRCh38
GRCh37152,838,501 - 52,870,095 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36152,611,089 - 52,642,719 (-)NCBINCBI36Build 36hg18NCBI36
Build 34152,550,521 - 52,582,152NCBI
Celera151,125,195 - 51,156,841 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef150,954,504 - 50,986,088 (-)NCBIHuRef
CHM1_1152,955,878 - 52,987,524 (-)NCBICHM1_1
T2T-CHM13v2.0152,254,294 - 52,290,972 (-)NCBIT2T-CHM13v2.0
Orc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394108,436,651 - 108,472,030 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4108,436,620 - 108,472,030 (+)EnsemblGRCm39 Ensembl
GRCm384108,575,705 - 108,616,030 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4108,579,423 - 108,614,833 (+)EnsemblGRCm38mm10GRCm38
MGSCv374108,252,059 - 108,287,438 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364108,077,406 - 108,112,765 (+)NCBIMGSCv36mm8
Celera4106,922,805 - 106,959,019 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.64NCBI
Orc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85128,552,975 - 128,581,943 (+)NCBIGRCr8
mRatBN7.25123,324,273 - 123,348,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5123,324,315 - 123,348,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5125,951,118 - 125,970,825 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05127,674,202 - 127,693,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05127,725,496 - 127,745,203 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05128,186,651 - 128,212,901 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5128,190,708 - 128,210,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05132,027,128 - 132,053,582 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45129,881,973 - 129,901,675 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15129,887,198 - 129,906,901 (+)NCBI
Celera5122,062,985 - 122,082,678 (+)NCBICelera
Cytogenetic Map5q34NCBI
Orc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554646,764,992 - 6,787,066 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554646,761,046 - 6,787,144 (+)NCBIChiLan1.0ChiLan1.0
ORC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21174,445,007 - 174,481,020 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11173,587,081 - 173,622,999 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0151,630,344 - 51,666,327 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1153,238,377 - 53,273,653 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl153,238,377 - 53,273,653 (-)Ensemblpanpan1.1panPan2
ORC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,965,339 - 8,995,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,971,732 - 8,995,481 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,117,639 - 9,147,426 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0159,088,800 - 9,118,581 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl159,088,747 - 9,118,578 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1158,901,830 - 8,931,588 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0158,990,730 - 9,020,498 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,008,666 - 9,038,436 (+)NCBIUU_Cfam_GSD_1.0
Orc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505866,805,540 - 66,835,637 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365228,586,591 - 8,610,747 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365228,580,661 - 8,610,750 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ORC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6159,819,339 - 159,852,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16159,819,302 - 159,852,306 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26147,478,622 - 147,512,210 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Orc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624859833,793 - 863,539 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624859833,360 - 863,631 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 36 20 41
Below cutoff 19

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007978755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000017258   ⟹   ENSCSAP00000016740
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2080,542,532 - 80,572,237 (+)Ensembl
RefSeq Acc Id: XM_007978755   ⟹   XP_007976946
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12080,540,331 - 80,571,989 (+)NCBI
Vero_WHO_p1.0NW_02366603336,698,289 - 36,730,187 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007976946 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016740.1
Reference Protein Sequences
RefSeq Acc Id: XP_007976946   ⟸   XM_007978755
- UniProtKB: A0A0D9S7A1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000016740   ⟸   ENSCSAT00000017258


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001275 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017258.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  2.30.30.490 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_lid_10 UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  BAH_dom UniProtKB/TrEMBL
  BAH_sf UniProtKB/TrEMBL
  Cdc6_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report csab:103224814 UniProtKB/TrEMBL
NCBI Gene ORC1 ENTREZGENE
PANTHER CELL DIVISION CONTROL PROTEIN 6-RELATED UniProtKB/TrEMBL
  PTHR10763:SF23 UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
  AAA_lid_10 UniProtKB/TrEMBL
  BAH UniProtKB/TrEMBL
  Cdc6_C UniProtKB/TrEMBL
PROSITE BAH UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
  BAH UniProtKB/TrEMBL
  Cdc6_C UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9S7A1 ENTREZGENE, UniProtKB/TrEMBL