BTG4 (BTG anti-proliferation factor 4)

Gene: BTG4 (BTG anti-proliferation factor 4) Chlorocebus sabaeus

Analyze

Symbol:

BTG4

Name:

BTG anti-proliferation factor 4

RGD ID:

18456077

Description:

ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); INVOLVED IN maternal-to-zygotic transition of gene expression (ortholog); negative regulation of mitotic cell cycle (ortholog); ASSOCIATED WITH ataxia telangiectasia (ortholog); BH4-deficient hyperphenylalaninemia A (ortholog); Carney-Stratakis syndrome (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC103248439; protein BTG4; serine/threonine-protein kinase BRSK1-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	102,841,089 - 102,846,723 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	102,828,923 - 102,832,544 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
ChlSab1.1 Ensembl	1	102,828,923 - 102,832,544 (-)	NCBI	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	23,126,818 - 23,145,203 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ataxia telangiectasia (ISO)

BH4-deficient hyperphenylalaninemia A (ISO)

Carney-Stratakis syndrome (ISO)

Chromosome 11, Partial Trisomy 11q (ISO)

intellectual disability (ISO)

Oocyte/Zygote/Embryo Maturation Arrest 8 (ISO)

Pyruvate Dehydrogenase E2 Deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

maternal-to-zygotic transition of gene expression (ISO)

negative regulation of cell population proliferation (IEA)

negative regulation of mitotic cell cycle (IEA,ISO)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

mRNA 3'-UTR binding (ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

BTG4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	102,841,089 - 102,846,723 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	102,828,923 - 102,832,544 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
ChlSab1.1 Ensembl	1	102,828,923 - 102,832,544 (-)	NCBI	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	23,126,818 - 23,145,203 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

BTG4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	111,383,826 - 111,514,725 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	111,467,526 - 111,514,367 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	111,338,251 - 111,385,450 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	110,843,465 - 110,888,274 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	110,843,467 - 110,888,274	NCBI
Celera	11	108,491,434 - 108,536,253 (-)	NCBI		Celera
Cytogenetic Map	11	q23.1	NCBI
HuRef	11	107,262,780 - 107,307,277 (-)	NCBI		HuRef
CHM1_1	11	111,221,343 - 111,266,174 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	111,393,991 - 111,524,873 (-)	NCBI		T2T-CHM13v2.0

Btg4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	51,013,486 - 51,031,224 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	50,972,201 - 51,031,175 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	51,102,147 - 51,119,924 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	51,060,901 - 51,119,875 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	50,924,106 - 50,927,805 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	50,868,231 - 50,871,930 (+)	NCBI		MGSCv36	mm8
Celera	9	48,402,491 - 48,406,190 (+)	NCBI		Celera
Cytogenetic Map	9	A5.3	NCBI
cM Map	9	27.84	NCBI

Btg4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	60,307,090 - 60,322,167 (+)	NCBI		GRCr8
mRatBN7.2	8	51,410,774 - 51,425,802 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	51,422,061 - 51,425,796 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	56,969,662 - 56,973,419 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	55,248,589 - 55,252,346 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	53,112,851 - 53,116,609 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	55,408,917 - 55,508,100 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	55,504,359 - 55,508,259 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	54,089,729 - 54,104,457 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	54,434,387 - 54,438,128 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	54,453,440 - 54,457,179 (+)	NCBI
Celera	8	50,968,431 - 50,972,180 (+)	NCBI		Celera
Cytogenetic Map	8	q23	NCBI

Btg4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	13,183,524 - 13,247,882 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	13,137,273 - 13,250,261 (-)	NCBI	ChiLan1.0	ChiLan1.0

BTG4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	112,202,213 - 112,258,119 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	113,294,277 - 113,350,171 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	106,374,407 - 106,394,341 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	110,219,490 - 110,236,589 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	110,219,490 - 110,236,589 (-)	Ensembl	panpan1.1		panPan2

BTG4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	21,559,307 - 21,578,314 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	21,559,298 - 21,592,854 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	21,480,978 - 21,514,692 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	21,584,992 - 21,618,739 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	21,599,278 - 21,618,612 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	21,646,077 - 21,679,757 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	21,546,057 - 21,579,789 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	21,595,046 - 21,628,924 (+)	NCBI		UU_Cfam_GSD_1.0

Btg4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	93,779,003 - 93,783,009 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936612	2,922,611 - 2,926,346 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936612	2,922,611 - 2,959,253 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BTG4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	39,237,461 - 39,301,588 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	39,253,116 - 39,281,327 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	44,183,288 - 44,194,432 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Btg4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	6,583,478 - 6,611,475 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624784	6,582,560 - 6,624,212 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008020807	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008020808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008020809	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008020810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038005235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005242735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000000938 ⟹ ENSCSAP00000015127

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	1	102,828,923 - 102,832,544 (-)	Ensembl

RefSeq Acc Id:

XM_008020810 ⟹ XP_008019001

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666043	23,127,855 - 23,145,203 (+)	NCBI

Sequence:

show sequence

ACGCCAGAACCTCCTTATCTATTTTTCTTGAATCATGAGAGATGAAATTGCAACAACAGTTTTC
TTTGTCACAAGATTGGTGAAAAAACATGATAAACTAAGTAAACAGCAAATAGAAGACTTTGCAG
AGAAGCTGATGACGATCTTGTTTGAAACATACAGAAGTCACTGGCACTCTGATTGCCCTTCTAA
AGGGCAAGCCTTCAGGTGCATCAGGATAAACAACAATCAGAATAAAGATCCCATTCTAGAAAGG
GCATGTGTGGAGAGTAATGTGGATTTTTCTCACCTGGGACTTCCAAAGGAGATGACCATATGGG
TAGATCCCTTTGAAGTGTGCTGTAGGTATGGTGAGAAAAACCATCCATTTACAGTTGCTTCTTT
TAAAGGCAGATGGGAGGAATGGGAACTATATCAGCAAATCAGTTATGCAGTTAGTAGAGCCTCA
TCAGACGATTCCTCTGGCCCTTCCTGCAATGAAGAAAGTTGTAGCAAGGAACCTCGTGTCATTC
CTAAAGTCAGCAATCCAAAGAGTATTTATCAGGTTGAAAACTTGAAACAGCCCTTTCAATCTTG
GTTCCAAATCCCCCGCAAAAAGAATGTGGTGGATGGCCGTGTTAGCCTCCTGGGAAACACTTAC
CATGGGTCGCAGAAGCACCCTAAGTGTTACAGGCCTTCTATGCACCGGGTGGACAGGTACCACT
GGGTCAACATACACCAATGACGCAGTGACTGGGCACATGGTGGGCGAGAGCTCAGAGGAGCGCC
TTTATTCTAAAATAAAAATGAATTTAAGGTTGAGAGGCCCATGAAACAAAAAATGACCATATTC
GGGACGAGGGTACACAATGGTAAATCCTCTCATACAGATCATGACTGTTCTTAGCTGTACTTTT
AATTCTTATTTAATTTTACATGAAGTTTTATGTAACATTAGTGAATGTACCCAGTAAGGTAACA
GAATGAAGATACTGACCTGTAATAAGACTCAATGAATTATGAAAAGTAATGGTTTAAATAAATA
TACAGTGTTTTTAA

hide sequence

RefSeq Acc Id:

XM_038005235 ⟹ XP_037861163

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666043	23,127,357 - 23,145,203 (+)	NCBI

RefSeq Acc Id:

XR_005242735

Type:

NON-CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666043	23,126,818 - 23,142,788 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008019001	(Get FASTA)	NCBI Sequence Viewer
	XP_037861163	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000015127
	ENSCSAP00000015127.1

RefSeq Acc Id:

ENSCSAP00000015127 ⟸ ENSCSAT00000000938

RefSeq Acc Id:	XP_037861163 ⟸ XM_038005235
- UniProtKB:	A0A0D9S2N8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_008019001 ⟸ XM_008020810
- UniProtKB:	A0A0D9S2N8 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000002908	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000000938.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.640.90	UniProtKB/TrEMBL
InterPro	Anti_prolifrtn	UniProtKB/TrEMBL
	BTG-like_sf	UniProtKB/TrEMBL
	BTG4	UniProtKB/TrEMBL
NCBI Gene	LOC103248439	ENTREZGENE
PANTHER	PROTEIN BTG4	UniProtKB/TrEMBL
	PTHR22978	UniProtKB/TrEMBL
Pfam	BTG	UniProtKB/TrEMBL
PRINTS	ANTIPRLFBTG1	UniProtKB/TrEMBL
PROSITE	BTG_1	UniProtKB/TrEMBL
	BTG_2	UniProtKB/TrEMBL
SMART	btg1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF160696	UniProtKB/TrEMBL
UniProt	A0A0D9S2N8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-08	BTG4	BTG anti-proliferation factor 4	LOC103248439	serine/threonine-protein kinase BRSK1-like	Symbol and/or name change	5135510	APPROVED
2020-12-03	LOC103248439	serine/threonine-protein kinase BRSK1-like	BTG4	BTG anti-proliferation factor 4	Data merged from RGD:18606288	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM