NEK2 (NIMA related kinase 2) - Rat Genome Database

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Gene: NEK2 (NIMA related kinase 2) Chlorocebus sabaeus
Analyze
Symbol: NEK2
Name: NIMA related kinase 2
RGD ID: 18436785
Description: ENCODES a protein that exhibits ATP binding (inferred); protein kinase activity (inferred); protein phosphatase binding (inferred); INVOLVED IN blastocyst development (ortholog); chromosome segregation (ortholog); mitotic sister chromatid segregation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); fundus dystrophy (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN centrosome (inferred); condensed nuclear chromosome (inferred); kinetochore (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase Nek2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12517,816,929 - 17,847,348 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2517,829,546 - 17,842,463 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605518,353,967 - 18,371,748 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
NEK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12517,816,929 - 17,847,348 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2517,829,546 - 17,842,463 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605518,353,967 - 18,371,748 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NEK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381211,658,256 - 211,675,621 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1211,658,657 - 211,675,630 (-)EnsemblGRCh38hg38GRCh38
GRCh371211,831,598 - 211,848,963 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361209,902,745 - 209,915,590 (-)NCBINCBI36Build 36hg18NCBI36
Build 341208,224,516 - 208,237,362NCBI
Celera1185,063,198 - 185,076,042 (-)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1182,509,044 - 182,526,419 (-)NCBIHuRef
CHM1_11213,104,002 - 213,121,393 (-)NCBICHM1_1
T2T-CHM13v2.01210,904,362 - 210,921,749 (-)NCBIT2T-CHM13v2.0
Nek2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391191,553,622 - 191,565,161 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1191,553,556 - 191,565,162 (+)EnsemblGRCm39 Ensembl
GRCm381191,821,449 - 191,833,049 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,821,444 - 191,833,050 (+)EnsemblGRCm38mm10GRCm38
MGSCv371193,645,352 - 193,656,928 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361193,522,177 - 193,533,657 (+)NCBIMGSCv36mm8
Celera1198,772,491 - 198,784,119 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.94NCBI
Nek2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,936,809 - 105,950,054 (+)NCBIGRCr8
mRatBN7.213103,405,818 - 103,419,063 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13103,405,819 - 103,419,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13105,925,762 - 105,939,011 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013107,309,612 - 107,322,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013104,524,711 - 104,537,957 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013110,511,546 - 110,524,750 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,511,668 - 110,522,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013115,071,708 - 115,084,946 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413107,895,671 - 107,908,904 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113108,084,908 - 108,096,196 (+)NCBI
Celera13102,845,789 - 102,858,739 (+)NCBICelera
Cytogenetic Map13q27NCBI
Nek2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554065,553,819 - 5,566,361 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554065,553,661 - 5,563,648 (+)NCBIChiLan1.0ChiLan1.0
NEK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2137,726,246 - 37,744,856 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1137,690,783 - 37,709,409 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01187,225,947 - 187,243,605 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,088,393 - 192,105,737 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,092,885 - 192,105,737 (-)Ensemblpanpan1.1panPan2
NEK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1710,039,617 - 10,052,511 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl710,040,187 - 10,052,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha79,617,334 - 9,630,223 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.079,745,394 - 9,758,577 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl79,745,398 - 9,758,560 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.179,668,208 - 9,681,172 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.079,770,376 - 9,783,529 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.079,894,933 - 9,908,005 (-)NCBIUU_Cfam_GSD_1.0
Nek2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934464,442,747 - 64,455,130 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365571,682,984 - 1,695,414 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365571,683,027 - 1,695,410 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9131,547,069 - 131,561,095 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19131,547,044 - 131,560,527 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29144,585,644 - 144,599,144 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Nek2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477117,334,681 - 17,352,259 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477117,334,782 - 17,351,609 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 2
Low 28 18 56
Below cutoff 8 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000013456   ⟹   ENSCSAP00000011456
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2517,829,546 - 17,842,463 (+)Ensembl
RefSeq Acc Id: XM_007988515   ⟹   XP_007986706
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12517,829,096 - 17,842,466 (+)NCBI
Vero_WHO_p1.0NW_02366605518,353,976 - 18,367,091 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988518   ⟹   XP_007986709
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12517,829,094 - 17,842,466 (+)NCBI
Vero_WHO_p1.0NW_02366605518,353,967 - 18,367,091 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988519   ⟹   XP_007986710
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12517,829,094 - 17,847,348 (+)NCBI
Vero_WHO_p1.0NW_02366605518,353,969 - 18,371,748 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007986706 (Get FASTA)   NCBI Sequence Viewer  
  XP_007986709 (Get FASTA)   NCBI Sequence Viewer  
  XP_007986710 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011456
  ENSCSAP00000011456.1
Reference Protein Sequences
RefSeq Acc Id: XP_007986710   ⟸   XM_007988519
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007986709   ⟸   XM_007988518
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007986706   ⟸   XM_007988515
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RS67 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000011456   ⟸   ENSCSAT00000013456


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015362 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013456.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report csab:103230133 UniProtKB/TrEMBL
NCBI Gene NEK2 ENTREZGENE
PANTHER CAMK FAMILY PROTEIN KINASE UniProtKB/TrEMBL
  NIMA-RELATED KINASE 2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RS67 ENTREZGENE, UniProtKB/TrEMBL